Multistate Models for the Analysis of Life History Data provides the first comprehensive treatment of multistate modeling and analysis, including parametric, nonparametric and semiparametric methods applicable to many types of life history data. Special models such as illness-death, competing risks and progressive processes are considered, as well as more complex models. The book provides both theoretical development and illustrations of analysis based on data from randomized trials and observational cohort studies in health research. It features: Discusses a wide range of applications of multistate models, Presents methods for both continuously and intermittently observed life history processes, Gives a thorough discussion of conditionally independent censoring and observation processes, Discusses models with random effects and joint models for two or more multistate processes, Discusses and illustrates software for multistate analysis that is available in R, Target audience includes those engaged in research and applications involving multistate models.

This book provides an introduction to multistate event history analysis. It is an extension of survival analysis, in which a single terminal event (endpoint) is considered and the time-to-event is studied. Multistate models focus on life histories or trajectories, conceptualized as sequences of states and sequences of transitions between states. Life histories are modeled as realizations of continuous-time Markov processes. The model parameters, transition rates, are estimated from data on event counts and populations at risk, using the statistical theory of counting processes. The Comprehensive R Network Archive (CRAN) includes several packages for multistate modeling. This book is about Biograph. The package is designed to (a) enhance exploratory analysis of life histories and (b) make multistate modeling accessible. The package incorporates utilities that connect to several packages for multistate modeling, including survival, eha, Epi, mvna,, mstate, msm, and TraMineR for sequence analysis. The book is a ‘hands-on’ presentation of Biograph and the packages listed. It is written from the perspective of the user. To help the user master the techniques and the software, a single data set is used to illustrate the methods and software. It is the subsample of the German Life History Survey, which was also used by Blossfeld and Rohwer in their popular textbook on event history modeling. Another data set, the Netherlands Family and Fertility Survey, is used to illustrate how Biograph can assist in answering questions on life paths of cohorts and individuals. The book is suitable as a textbook for graduate courses on event history analysis and introductory courses on competing risks and multistate models. It may also be used as a self-study book. The R code used in the book is available online. Frans Willekens is affiliated with the Max Planck Institute for Demographic Research (MPIDR) in Rostock, Germany. He is Emeritus Professor of Demography at the University of Groningen, a Honorary Fellow of the Netherlands Interdisciplinary Demographic Institute (NIDI) in the Hague, and a Research Associate of the International Institute for Applied Systems Analysis (IIASA), Laxenburg, Austria. He is a member of Royal Netherlands Academy of Arts and Sciences (KNAW). He has contributed to the modeling and simulation of life histories, mainly in the context of population forecasting.

This book primarily aims to discuss emerging topics in statistical methods and to booster research, education, and training to advance statistical modeling on interval-censored survival data. Commonly collected from public health and biomedical research, among other sources, interval-censored survival data can easily be mistaken for typical right-censored survival data, which can result in erroneous statistical inference due to the complexity of this type of data. The book invites a group of internationally leading researchers to systematically discuss and explore the historical development of the associated methods and their computational implementations, as well as emerging topics related to interval-censored data. It covers a variety of topics, including univariate interval-censored data, multivariate interval-censored data, clustered interval-censored data, competing risk interval-censored data, data with interval-censored covariates, interval-censored data from electric medical records, and misclassified interval-censored data. Researchers, students, and practitioners can directly make use of the state-of-the-art methods covered in the book to tackle their problems in research, education, training and consultation.

Hugely popular textbook on survival analysis for graduate students of statistics and biostatistics, mainly due to its accessibility and breadth of examples. This is a standard course on graduate programs in biostatistics and statistics, and this is one of the most popular textbooks. Updated with modern methods covering Bayesian survival analysis, joint models, and more.

Nonparametric Models for Longitudinal Data with Implementations in R presents a comprehensive summary of major advances in nonparametric models and smoothing methods with longitudinal data. It covers methods, theories, and applications that are particularly useful for biomedical studies in the era of big data and precision medicine. It also provides flexible tools to describe the temporal trends, covariate effects and correlation structures of repeated measurements in longitudinal data. This book is intended for graduate students in statistics, data scientists and statisticians in biomedical sciences and public health. As experts in this area, the authors present extensive materials that are balanced between theoretical and practical topics. The statistical applications in real-life examples lead into meaningful interpretations and inferences. Features: Provides an overview of parametric and semiparametric methods Shows smoothing methods for unstructured nonparametric models Covers structured nonparametric models with time-varying coefficients Discusses nonparametric shared-parameter and mixed-effects models Presents nonparametric models for conditional distributions and functionals Illustrates implementations using R software packages Includes datasets and code in the authors’ website Contains asymptotic results and theoretical derivations

Mixture models are a powerful tool for analyzing complex and heterogeneous datasets across many scientific fields, from finance to genomics. Mixture Models: Parametric, Semiparametric, and New Directions provides an up-to-date introduction to these models, their recent developments, and their implementation using R. It fills a gap in the literature by covering not only the basics of finite mixture models, but also recent developments such as semiparametric extensions, robust modeling, label switching, and high-dimensional modeling. Features Comprehensive overview of the methods and applications of mixture models Key topics include hypothesis testing, model selection, estimation methods, and Bayesian approaches Recent developments, such as semiparametric extensions, robust modeling, label switching, and high-dimensional modeling Examples and case studies from such fields as astronomy, biology, genomics, economics, finance, medicine, engineering, and sociology Integrated R code for many of the models, with code and data available in the R Package MixSemiRob Mixture Models: Parametric, Semiparametric, and New Directions is a valuable resource for researchers and postgraduate students from statistics, biostatistics, and other fields. It could be used as a textbook for a course on model-based clustering methods, and as a supplementary text for courses on data mining, semiparametric modeling, and high-dimensional data analysis.

Praise for the first edition: [This book] reflects the extensive experience and significant contributions of the author to non-linear and non-Gaussian modeling. ... [It] is a valuable book, especially with its broad and accessible introduction of models in the state-space framework. –Statistics in Medicine What distinguishes this book from comparable introductory texts is the use of state-space modeling. Along with this come a number of valuable tools for recursive filtering and smoothing, including the Kalman filter, as well as non-Gaussian and sequential Monte Carlo filters. –MAA Reviews Introduction to Time Series Modeling with Applications in R, Second Edition covers numerous stationary and nonstationary time series models and tools for estimating and utilizing them. The goal of this book is to enable readers to build their own models to understand, predict and master time series. The second edition makes it possible for readers to reproduce examples in this book by using the freely available R package TSSS to perform computations for their own real-world time series problems. This book employs the state-space model as a generic tool for time series modeling and presents the Kalman filter, the non-Gaussian filter and the particle filter as convenient tools for recursive estimation for state-space models. Further, it also takes a unified approach based on the entropy maximization principle and employs various methods of parameter estimation and model selection, including the least squares method, the maximum likelihood method, recursive estimation for state-space models and model selection by AIC. Along with the standard stationary time series models, such as the AR and ARMA models, the book also introduces nonstationary time series models such as the locally stationary AR model, the trend model, the seasonal adjustment model, the time-varying coefficient AR model and nonlinear non-Gaussian state-space models. About the Author: Genshiro Kitagawa is a project professor at the University of Tokyo, the former Director-General of the Institute of Statistical Mathematics, and the former President of the Research Organization of Information and Systems.

Statistical methods for sequential hypothesis testing and changepoint detection have applications across many fields, including quality control, biomedical engineering, communication networks, econometrics, image processing, security, etc. This book presents an overview of methodology in these related areas, providing a synthesis of research from the last few decades. The methods are illustrated through real data examples, and software is referenced where possible. The emphasis is on providing all the theoretical details in a unified framework, with pointers to new research directions.

Martingale Methods in Statistics provides a unique introduction to statistics of stochastic processes written with the author’s strong desire to present what is not available in other textbooks. While the author chooses to omit the well-known proofs of some of fundamental theorems in martingale theory by making clear citations instead, the author does his best to describe some intuitive interpretations or concrete usages of such theorems. On the other hand, the exposition of relatively new theorems in asymptotic statistics is presented in a completely self-contained way. Some simple, easy-to-understand proofs of martingale central limit theorems are included. The potential readers include those who hope to build up mathematical bases to deal with high-frequency data in mathematical finance and those who hope to learn the theoretical background for Cox’s regression model in survival analysis. A highlight of the monograph is Chapters 8-10 dealing with Z-estimators and related topics, such as the asymptotic representation of Z-estimators, the theory of asymptotically optimal inference based on the LAN concept and the unified approach to the change point problems via "Z-process method". Some new inequalities for maxima of finitely many martingales are presented in the Appendix. Readers will find many tips for solving concrete problems in modern statistics of stochastic processes as well as in more fundamental models such as i.i.d. and Markov chain models.