Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries, by Gary D. Stoner and Li-Shu Wang Cancer Prevention by Different Forms of Tocopherols, by Chung S. Yang and Nanjoo Suh Cancer Chemopreventive and Therapeutic Potential of Guggulsterone, by Inas Almazari and Young-Joon Surh Inhibition of UVB-Induced Nonmelanoma Skin Cancer: A Path from Tea to Caffeine to Exercise to Decreased Tissue Fat, by Allan H. Conney, You-Rong Lou, Paul Nghiem, Jamie J. Bernard, George C. Wagner and Yao-Ping Lu Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges, by Clarissa Gerhauser A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics, by Zheng-Yuan Su, Limin Shu, Tin Oo Khor, Jong Hun Lee, Francisco Fuentes and Ah-Ng Tony Kong Keap1-Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane, by Thomas W. Kensler, Patricia A. Egner, Abena S. Agyeman, Kala Visvanathan, John D. Groopman, Jian-Guo Chen, Tao-Yang Chen, Jed W. Fahey and Paul Talalay Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms, by Albena T. Dinkova-Kostova Human Cancer Chemoprevention: Hurdles and Challenges, by Vaqar Mustafa Adhami and Hasan Mukhtar Personalizing Lung Cancer Prevention Through a Reverse Migration Strategy, by Kathryn A. Gold, Edward S. Kim, Ignacio I. Wistuba and Waun K. Hong Natural-Agent Mechanisms and Early-Phase Clinical Development, by Janet L. Wang, Kathryn A. Gold and Scott M. Lippman

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Functional Foods in Cancer Prevention and Therapy presents the wide range of functional foods associated with the prevention and treatment of cancer. In recent decades, researchers have made progress in our understanding of the association between functional food and cancer, especially as it relates to cancer treatment and prevention. Specifically, substantial evidence from epidemiological, clinical and laboratory studies show that various food components may alter cancer risk, the prognosis after cancer onset, and the quality of life after cancer treatment. The book documents the therapeutic roles of well-known functional foods and explains their role in cancer therapy. The book presents complex cancer patterns and evidence of the effective ways to control cancers with the use of functional foods. This book will serve as informative reference for researchers focused on the role of food in cancer prevention and physicians and clinicians involved in cancer treatment. Discusses the role of functional foods in cancer therapy Presents research-based evidence of the role of herbs and bioactive foods in cancer treatment and prevention Provides the most current, concise, scientific information regarding the efficacy of functional foods in preventing cancer and improving the quality of life Explores antioxidants, phytochemicals, nutraceuticals, herbal medicine and supplements in relation to cancer prevention and treatment Contains a clinical approach to the use of functional foods to prevent and treat cancer Emphasizes the role and mechanism of functional foods, including the characterization of active compounds on cancer prevention and treatment

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text.

This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer. The book is divided into three parts to better communicate the important findings related to phytochemicals and mitochondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mitochondria function in regulating the process of tumorigenesis, and the role of mitochondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals. The third part provides updates on phytochemicals targeting mitochondria for cancer therapy, an overview of action of phytochemicals on cancer stem cells, updates on the role of microRNA in phytochemicals-based therapy of cancer, and updates on phytochemicals-based translation research on therapy for metastatic cancer.

This book provides a holistic view of natural products and remedies that have been used to treat cancer. The editors aim to educate readers about the importance of the translational role of natural products in cancer treatment by compiling 14 chapters. The book emphasizes an integrative approach to the topic by blending traditional knowledge that supports alternative therapies with the science of phytochemicals and drug discovery technologies as a means to manage the disease. Key topics include alternative therapies (such as aromatherapy and immune boosting herbal medications), cytotoxic and anti-cancer phytochemicals, drug delivery and discovery technologies (including high-throughput screening) and some drug targets of interest for cancer treatment (such as topoisomerases and caspases). Readers will be able to learn about natural sources of ant-cancer compounds, and the methods used by research and development experts in pharmaceutical and nutraceutical industries to isolate and formulate these compounds. This book will be a handy resource for a wide range of readers. This includes researchers, traditional medical practitioners, PG students, Ph.D. scholars and general readers to understand the role of natural products in cancer treatment. key features - Explains the importance of alternative therapies in the management of cancer - Emphasizes the ethnopharmacological approaches to cancer - Explores natural anticancer drug libraries - Discusses the role of modern cancer targets and the importance of in-silico tools in anticancer drug discovery - Addresses modern drug discovery tools and drug delivery technologies concerning their applications in cancer treatment. - Includes references for further reading

Natural Products as Anticancer Agents introduces the different types of natural products that have been used for cancer treatment. Divided into four parts, covering anticancer agents derived from terrestrial plants, anticancer agents derived from the marine environment, and anticancer agents derived from microorganisms, as well as evaluation of new anticancer agents, each part includes discussion of the properties, synthesis/extraction, storage, mechanism of action, and usage of the molecules. Discussion of the future prospects in anticancer natural products—including several new trends and an indication of where research in this area is likely to go in the future—is also included. - Assists in the identification of risk factors associated with the drug development process - Includes process diagrams detailing the procedure for the isolation and purification of molecules - Covers cost-effective green approaches in the development of anticancer drugs

This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

In a world grappling with the relentless impact of cancer, claiming nearly 10 million lives in 2020 alone, the pursuit of effective prevention and treatment methods is more crucial than ever. Harnessing Medicinal Plants in Cancer Prevention and Treatment delves into promising medicinal plants, exploring their potential in the prevention and treatment of various types of cancer. Acknowledging the limitations and risks associated with synthetic medicines, the book emphasizes the significance of traditional medicine, revealing that approximately 80% of the global population relies on plant-based remedies for primary health care. Within these pages, readers will find a comprehensive exploration of diverse medicinal plants and their active compounds, unraveling their mode of action against cancer. The content spans continents, from the phytochemical and biological properties of anticancer medicinal plants in India to the role of Chinese and Thai plants in cancer prevention and treatment. Each chapter meticulously examines specific plants or compounds, such as the renowned Curcuma longa, or the intriguing Momordica charantia, providing an in-depth analysis of their anticancer properties. This book elucidates the multifaceted role of plant-derived compounds in various cancer types, addressing their efficacy and safety profiles. The book is rich with insights into the potential of bioactive compounds to serve as lead candidates in drug discovery, highlighting the importance of plants in developing effective anticancer agents. This book is an invaluable resource for a diverse audience, including biotechnologists, plant biologists, pharmacologists, and cancer-related researchers.

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​