Cervical Cancer - Recent Advances and New Perspectives is a review of interesting and clinically important advances in the tumor biology and treatment of cervical cancer. The book covers major aspects of scientific progress in the treatment of cervical cancer, focusing on new knowledge due to advances in molecular techniques, understanding of tumor biology, and innovative new treatment options. This book brings together an interesting collection of innovations in the treatment of cervical cancer and opinions from specialists in this field from around the world.

Written and edited by global leaders in the field, Principles of Gynecologic Oncology Surgery, 2nd Edition, offers a practical, "how-to" approach to the most important and commonly performed procedures in this fast-moving specialty. Organized by cancer type, this comprehensive reference covers issues related to surgical anatomy, patient evaluation, procedure indications and details, and management of complications for both open and minimally invasive procedures. It clearly describes the critical steps for each procedure, provides up-to-date information on the recent literature, and includes high-quality illustrations of anatomy and technique. - Covers the most current treatment and management options with expert guidance from leading surgeons at top cancer centers throughout the world. - Contains new chapters on surgery in pregnant women who have been diagnosed with gynecologic cancers; perioperative analgesic management; uterine transposition; and uterine transplantation. - Provides increased coverage of AI and its use in navigation of surgery; a new section on thoracic cavity and chest wall anatomy; significant updates regarding Enhanced Recovery After Surgery (ERAS); and an expanded discussion of radiation-related complications and their management. - Addresses the diagnosis, management and prevention of surgical complications. - Provides timely updates on newly recommended sentinel lymph node mapping for endometrial cancer staging, PARP inhibitors in ovarian cancer, molecular subtyping in endometrial cancer, cervical cancer and standard of care. and updates on both laparoscopic and robotic surgery. - Includes expert coverage of reconstructive surgery, colorectal surgery, urology, and vascular surgery, each written by surgeon leaders in that particular field. - Features procedural videos that guide you through a multitude of procedures, including abdominal exploration using laparoscopy for evaluation of cytoreduction in advanced ovarian cancer, laparoscopic hysterectomies with sentinel lymph node mapping, radical hysterectomy, robotic radical trachelectomy, and more, as well as high-quality illustrations including surgical photos, pathology photos, imaging, and anatomical figures. - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

An exciting class of regulatory small noncoding RNAs (ncRNAs) has emerged in recent years that play key role(s) in the etiology/pathogenesis and diagnosis/prognosis of various human diseases including various hematologic and solid cancers, cardiovascular diseases including stroke/atherosclerosis, diabetes, obesity, and metabolic disorders, neuropathies, neurodegeneration including Alzheimer’s Disease, Parkinson’s Disease or Multiple Sclerosis, neurological disorders including epilepsy and muscular dystrophies, liver diseases, pulmonary fibrosis, immune-mediated inflammatory disorders and inflammatory bowel disease, gastritis, autoimmune disorders including arthritis, acromegaly, chronic kidney disease, allergic rhinitis, vitiligo, osteoporosis, obstructive sleep apnea, ocular disease, periodontitis, skeletal muscle atrophy, and parasitic diseases including leishmaniasis, amongst others. These ncRNAs include primarily microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), small interfering RNAs (siRNAs) or exosomal RNAs (exRNAs), etc. that modulate the expression of target genes thus potentially regulating protein expression in normal versus diseased individuals. This Research Topic recognizes the importance of and seeks to explore, ncRNAs in the diagnosis, etiology, progression, prognosis, and treatment of human disease as well as novel biomarker discovery by multi-omics technologies and other methodologies. Indeed, high-throughput technologies employing deep sequencing, proteogenomic, microarrays, and quantitative real-time PCR have begun to shed new light on the architecture of ncRNA landscapes in various diseases and key signal transduction cascades modulated by these ncRNAs in disease pathology. Epigenetic control of gene expression mediated via miRNAs, for instance, has expanded our understanding of transcriptional and post-transcriptional regulation of gene expression by critical ncRNAs in the cellular milieu. Network biology approaches including the construction of relevant ncRNA networks, ncRNA-mRNA networks, and bioinformatics for mining of ncRNAs, are gaining greater relevance in the search for ‘target hubs’ or novel biomarker(s) of disease. Delineation of ncRNA signatures by transcriptomic profiling or RNA-seq, for example, is an important milestone in furthering our knowledge of the repertoire of specific ncRNAs implicated in various diseases. Further, elucidation of the specific steps of the signaling cascades where ncRNAs exert their regulatory actions will augment our understanding of diseases. This will lead to the development of (i) a novel biomarker, or biomarker signature panel, for disease; (ii) ncRNA-based companion diagnostics for diagnosis of disease; (iii) point-of-care testing devices based on ncRNAs; (iv) newer therapeutic agents that target novel biomarkers with specificity, thereby reducing toxicity; (v) ncRNA-based prophylactic approaches of the future; and, (vi) ncRNA-based prognosis of disease.

This new edition features updated information on all aspects of the diagnosis and management of ovarian cancer. Embracing knowledge from around the world, this multidisciplinary book discusses current approaches to ovarian cancer that have helped stabilize the rate of both incidences and fatality for the disease. The chapters focus on genetic screening and advances in management, including the optimization of chemotherapeutic agents, gene therapy, and the latest laparoscopic and robotic surgical techniques. Further chapters address psychosocial and quality-of-life issues as well. The book is a must-have resource for wide range of practitioners who care for patients with ovarian cancer and researchers who study the disease.

Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.

Gynecologic cancers include malignancies of the female genital tract involving the vulva, vagina, cervix, uterus, fallopian tubes or ovaries. In the USA, 98,280 women had gynecological cancers in 2015, and 30,440 died of these cancers. World wide, the number of women who had cancers of the female genital tract was 1,085,900, in 2012 and the number of deaths was 417,600. Cancers of the uterus, cervix and ovary are most common. Widespread screening with the Pap test has allowed physicians to find per-cancerous changes in the cervix and vagina. This has assisted in identifying some invasive cancers early. Multidisciplinary team of experts includes specialists in medical oncology, gynecologic oncology, radiology, urology, radiotherapy, and surgery who work together to determine the best treatment approach for the patient. Recent progress in the development of new surgical techniques has transformed the treatment of gynecologic cancers, resulting in greater surgical precision and fewer complications. In addition targeted adjuvant therapy has become useful in improving the oncologic outcome of patients with these cancers.