Real life phenomena in engineering, natural, or medical sciences are often described by a mathematical model with the goal to analyze numerically the behaviour of the system. Advantages of mathematical models are their cheap availability, the possibility of studying extreme situations that cannot be handled by experiments, or of simulating real systems during the design phase before constructing a first prototype. Moreover, they serve to verify decisions, to avoid expensive and time consuming experimental tests, to analyze, understand, and explain the behaviour of systems, or to optimize design and production. As soon as a mathematical model contains differential dependencies from an additional parameter, typically the time, we call it a dynamical model. There are two key questions always arising in a practical environment: 1 Is the mathematical model correct? 2 How can I quantify model parameters that cannot be measured directly? In principle, both questions are easily answered as soon as some experimental data are available. The idea is to compare measured data with predicted model function values and to minimize the differences over the whole parameter space. We have to reject a model if we are unable to find a reasonably accurate fit. To summarize, parameter estimation or data fitting, respectively, is extremely important in all practical situations, where a mathematical model and corresponding experimental data are available to describe the behaviour of a dynamical system.

This text focuses on the use of smoothing methods for developing and estimating differential equations following recent developments in functional data analysis and building on techniques described in Ramsay and Silverman (2005) Functional Data Analysis. The central concept of a dynamical system as a buffer that translates sudden changes in input into smooth controlled output responses has led to applications of previously analyzed data, opening up entirely new opportunities for dynamical systems. The technical level has been kept low so that those with little or no exposure to differential equations as modeling objects can be brought into this data analysis landscape. There are already many texts on the mathematical properties of ordinary differential equations, or dynamic models, and there is a large literature distributed over many fields on models for real world processes consisting of differential equations. However, a researcher interested in fitting such a model to data, or a statistician interested in the properties of differential equations estimated from data will find rather less to work with. This book fills that gap.

This book shows how modern Applied Mathematics influences everyday life. It features contributors from universities, research institutions and industry, who combine research and review papers to present a survey of current research. More than 20 contributions are divided into scales: nano, micro, macro, space and real life. In addition, coverage includes engaging and informative case studies as well as complex graphics and illustrations, many of them in color.

Optimization and Operations Research is a component of Encyclopedia of Mathematical Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Optimization and Operations Research is organized into six different topics which represent the main scientific areas of the theme: 1. Fundamentals of Operations Research; 2. Advanced Deterministic Operations Research; 3. Optimization in Infinite Dimensions; 4. Game Theory; 5. Stochastic Operations Research; 6. Decision Analysis, which are then expanded into multiple subtopics, each as a chapter. These four volumes are aimed at the following five major target audiences: University and College students Educators, Professional Practitioners, Research Personnel and Policy Analysts, Managers, and Decision Makers and NGOs.

Real life phenomena in engineering, natural, or medical sciences are often described by a mathematical model with the goal to analyze numerically the behaviour of the system. Advantages of mathematical models are their cheap availability, the possibility of studying extreme situations that cannot be handled by experiments, or of simulating real systems during the design phase before constructing a first prototype. Moreover, they serve to verify decisions, to avoid expensive and time consuming experimental tests, to analyze, understand, and explain the behaviour of systems, or to optimize design and production. As soon as a mathematical model contains differential dependencies from an additional parameter, typically the time, we call it a dynamical model. There are two key questions always arising in a practical environment: 1 Is the mathematical model correct? 2 How can I quantify model parameters that cannot be measured directly? In principle, both questions are easily answered as soon as some experimental data are available. The idea is to compare measured data with predicted model function values and to minimize the differences over the whole parameter space. We have to reject a model if we are unable to find a reasonably accurate fit. To summarize, parameter estimation or data fitting, respectively, is extremely important in all practical situations, where a mathematical model and corresponding experimental data are available to describe the behaviour of a dynamical system.

Contains topics including modelling the dynamics of signalling pathways, modelling metabolic networks using power-laws and S-systems, modelling reaction kinetics in cells, the regulatory design of cellular processes, metabolomics and fluxomics, modelling cellular signalling systems, and systems analysis of MAPK signal transduction.

This volume reviews longitudinal models and analysis procedures for use in the behavioral and social sciences. Written by distinguished experts in the field, the book presents the most current approaches and theories, and the technical problems that may be encountered along the way. Readers will find new ideas about the use of longitudinal analysis in solving problems that arise due to the specific nature of the research design and the data available. Longitudinal Models in the Behavioral and Related Sciences opens with the latest theoretical developments. In particular, the book addresses situations that arise due to the categorical nature of the data, issues related to state space modeling, and potential problems that may arise from network analysis and/or growth-curve data. The focus of part two is on the application of longitudinal modeling in a variety of disciplines. The book features applications such as heterogeneity on the patterns of a firm’s profit, on house prices, and on delinquent behavior; non-linearity in growth in assessing cognitive aging; measurement error issues in longitudinal research; and distance association for the analysis of change. Part two clearly demonstrates the caution that should be taken when applying longitudinal modeling as well as in the interpretation of the results. This new volume is ideal for advanced students and researchers in psychology, sociology, education, economics, management, medicine, and neuroscience.