Nutritional Modulation of Neural Function probes into the mechanisms by which ingested foods can exert such influences and modulate neuronal function. The compendium is based on the meeting held in Santa Barbara, California, in March 1986, under the aegis of the Brain Research Institute of the University of California, Los Angeles. The papers in the book examines topics such as the effects of food on the release of peptide hormones from the gastrointestinal tract and the effect of these peptides on central nervous system function; the mechanisms by which mammals regulate ingestive behaviors; food myths and the effects of various nutritional components to behavior and mental functioning; the evidence that glucose can modulate opioid receptors and alter a number of opioid-dependent behaviors; and the role of zinc metabolism in limbic system structures in the pathogenesis of seizures. Neurologists, pathologists, and researchers in the field of medicine will find the text very insightful.

In ten essays commissioned by the NutraSweet Company, contributors from the health and food sciences explain to the general consumer that nutrition is not as simple as some people make it out to be, and there are still questions about sugar, cholesterol, obesity, and other topics. Annotation copyrig

Within the past decade there has been a veritable explosion of interest in the relationship between food and human behavior. It seems that there is an insatiable desire to find connections between what we eat and what we do. A clear example of this is the proliferation of books, magazine and newspaper articles, and television and radio programs devoted to the topic. More important, however, is the increased attention the scientific community is giving to the study of nutrition and behavior as evidenced by the growth of research, the development of undergraduate and graduate programs, and the number of scientific conferences addressing the prob lems in this area. The burgeoning scientific interest in this field makes it a very appropriate time for this book. The principal goal of Nutrition and Behavior: New Perspectives is to provide a comprehensive examination of the scientific evidence dealing with relationships between nutritional variables and behavior. Although findings in research using experimental animals will be introduced, the primary emphasis will be on investigating the nutrition-behavior relation ship in our own species. The first chapter provides a historical introduction to the area and examines the techniques used in the scientific assessment of nutrition and behavior. This material gives the reader the necessary background to place recent research on nutrition and behavior within a wider perspective and to evaluate its reliability and validity.

Natural products and functional/medical foods are now widely acknowledged as having an effect on the microbiome of the intestine, which in turn influences the outcome of certain disease. This book reviews the impact and effects of natural products and functional/medical foods (nutritional programming) on disease management, specifically focusing on diseases related to 1) Inflammation and Immunity, 2) Cancer, COPD and Cachexia, 3) Allergy and 4) Brain Neuro/Immune. Hippocrates said "let medicine be thy food and food be thy medicine". While most of us are familiar with Hippocrates famous words, we admit that in recent times, the disciplines of pharma and nutrition have evolved separately. Today, with the ever growing burden of diseases in modern society, we see a convergence of the two in relation to specific disease prevention and treatment. This re-discovered common ground between the complementary values of pharma and nutrition can be conceptualized in the term pharma-nutrition. Various chapters in the book review the aspects of molecular characteristics of food ingredients towards clinical effectiveness and relevance.

First multi-year cumulation covers six years: 1965-70.

amounts can produce a deleterious effect on animals. In an attempt to quantify this potential for toxicity and to give sufficient margin for safety, JECFA has introduced an acceptable daily intake (ADI) level for food additives. For example, the ADI values granted for saccharin, aspartame, cyclamate, acesulfame-K and sucralose are 2. 5, 40, 11,9 and 1 3. 5 mg kg- body weight per day, respectively. Chapter 2 on regulatory aspects of low-calorie food elaborates these points. The additives that are to be consumed in large amounts, such as a fat replacement product like 'Olestra' or a new bulking material like 'polydextrose', present a more complex problem as far as the evaluation of their toxicity is concerned. Normal safety testing of an additive, such as a high-intensity sweetener, requires that the test animals are fed with a sufficiently high dosage in order to produce an effect and then on that basis an ADI value is calculated. In cases like 'Olestra' and 'polydex trose', which are not normally present in diet or metabolised to dietary constituents, such an approach will obviously not be applicable, or of any use, in calculating an ADI value. Due to these factors the regulatory authorities have not yet been able to produce any guidelines for toxicity trials for additives that are to be taken in food in large quantities.