Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.

Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.

A regional and functional approach to learning human neuroanatomy – enhanced by additional full-color illustrations and PowerPoint® slides of all images in the text for instructors! Neuroanatomy: Text and Atlas covers neuroanatomy from both a functional and regional perspective to provide an understanding of how the components of the central nervous system work together to sense the world around us, regulate body systems, and produce behavior. This trusted text thoroughly covers the sensory, motor, and integrative skills of the brains and presents an overview of the function in relation to structure and the locations of the major pathways and neuronal integrative regions. Neuroanatomy: Text and Atlas also teaches readers how to interpret the new wealth of human brain images by developing an understanding of the anatomical localization of brain function. The authoritative core content of myelin-stained histological sections is enhanced by informative line illustrations, angiography, and brain views produced by MRI, and other imaging technologies. • Revised and updated to reflect advances in clinical neuroanatomy and neural science • Full-color illustrations enrich the text, including many new to this edition • Chapters begin with a clinical case to illustrate the connections and functions of the key material • Chapters end with a series of multiple-choice review questions • NEW Online learning center will display brain views produced by MRI and PET • Increases knowledge of the regional and functional organization of the spinal cord and brain, one system at a time • Provides thorough coverage of the sensory, motor, and integrative systems of the brain, together with cerebral vasculature • Promotes understanding of the complex details of neuroanatomy needed for accurate interpretation of radiological image • Comprehensive atlas provides key views of the surface anatomy of the central nervous systems and photographs of myelin-stained sections in three anatomical planes • Includes learning aids such as clinical topics, boxes, chapter summaries, and a Glossary of key terms and structures

The third edition of this concise but comprehensive textbook follows on from the highly-regarded earlier editions in providing the trainee and general physician with a better understanding of the principles of neurology. Retaining an emphasis on the core clinical skills of history taking and careful neurological examination, the new edition has been thoroughly revised and updated to take into account new developments in investigation and treatment. Particular areas of enhanced coverage include headache, expanded beyond migraine to cover other presentations, and multiple sclerosis. Completely new chapters discuss the increasing role of neurogenetics in the understanding and treatment of neurological disease, the importance of pain and its management and neurological complications associated with respiratory intensive care. Following the sad death of Dr. David Marsden, Dr John Scadding has joined the editorial team retaining the 'Queen Square' connection of earlier editions.