This book offers a comprehensive review of the latest developments, challenges and trends in C1-based (one-carbon based) bioproduction, and it presents an authoritative account of one-carbon compounds as promising alternative microbial feedstocks. The book starts with a perspective on the future of C1 compounds as alternative feedstocks for microbial growth, and their vital role in the establishment of a sustainable circular carbon economy, followed by several chapters in which expert contributors discuss about the recent strategies and address key challenges regarding one or more C1 feedstocks. The book covers topics such as acetogenic production from C1 feedstocks, aerobic carboxydotrophic bacteria potential in industrial biotechnology, bioconversion of methane to value-added compounds, combination of electrochemistry and biology to convert C1 compounds, and bioprocesses based on C1-mixotrophy. Particular attention is given to the current metabolic engineering, systems biology, and synthetic biology strategies applied in this field.

This book offers a comprehensive review of the latest developments, challenges and trends in C1-based (one-carbon based) bioproduction, and it presents an authoritative account of one-carbon compounds as promising alternative microbial feedstocks. The book starts with a perspective on the future of C1 compounds as alternative feedstocks for microbial growth, and their vital role in the establishment of a sustainable circular carbon economy, followed by several chapters in which expert contributors discuss about the recent strategies and address key challenges regarding one or more C1 feedstocks. The book covers topics such as acetogenic production from C1 feedstocks, aerobic carboxydotrophic bacteria potential in industrial biotechnology, bioconversion of methane to value-added compounds, combination of electrochemistry and biology to convert C1 compounds, and bioprocesses based on C1-mixotrophy. Particular attention is given to the current metabolic engineering, systems biology, and synthetic biology strategies applied in this field.

Application of Process Intensification (PI) presents a set of radically innovative principles in process and equipment design, which can bring significant benefits in terms of process efficiency, capital and operating expenses, quality, process safety, and sustainability. Typical approaches in bioprocess intensification are the reduction of the number of production steps, continuous processing, integrated processes, and alternative energy inputs.

This book provides in-depth insights into the most recent developments in different areas of microbial methane and methanol utilization, including novel fundamental discoveries in genomics and physiology, innovative strategies for metabolic engineering and new synthetic approaches for generation of feedstocks, chemicals and fuels from methane, and finally economics and the implementation of industrial biocatalysis using methane consuming bacteria. Methane, as natural gas or biogas, penetrates every area of human activity, from households to large industries and is often promoted as the cleanest fuel. However, one should not forget that this bundle of energy, carbon, and hydrogen comes with an exceptionally large environmental footprint. To meet goals of long-term sustainability and human well-being, all areas of energy, chemicals, agriculture, waste-management industries must go beyond short-term economic considerations and target both large and small methane emissions. The search for new environment-friendly approaches for methane capture and valorization is an ongoing journey. While it is not yet apparent which innovation might represent the best solution, it is evident that methane biocatalysis is one of the most promising paths. Microbes are gatekeepers of fugitive methane in Nature. Methane-consuming microbes are typically small in number but exceptionally big in their impact on the natural carbon cycle. They control and often completely eliminate methane emission from a variety of biological and geothermal sources. The tremendous potential of these microbial systems, is only now being implemented in human-made systems. The book addresses professors, researchers and graduate students from both academia and industry working in microbial biotechnology, molecular biology and chemical engineering.

This publication investigates key aspects surrounding the sustainability of bioeconomy development: the use of biomass as feedstock for future production; the design and building of biorefineries for the manufacture of a range of fuels, chemicals and materials, and also for electricity generation.

Fermentation Microbiology and Biotechnology, 4th Edition explores and illustrates the broad array of metabolic pathways employed for the production of primary and secondary metabolites, as well as biopharmaceuticals. This updated and expanded edition addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynamics to protein and co-factor engineering. It also sheds light on the new strategies employed by industrialist for increasing tolerance and endurance of microorganisms to the accumulation of toxic wastes in microbial-cell factories. The new edition builds upon the fine pedigree of its earlier predecessors and extends the spectrum of the book to reflect the multidisciplinary and buoyant nature of this subject area. Key Features Covers the whole spectrum of the field from fermentation kinetics to control of fermentation and protein engineering. Includes case studies specifically designed to illustrate industrial applications and current state-of-the-art technologies. Presents the contributions of eminent international academics and industrial experts. Offers new chapters addressing: The prospects and the role of bio-fuels refineries, Control of metabolic efflux to product formation in microbial-cell factories and Improving tolerance of microorganisms to toxic byproduct accumulation in the fermentation vessel.

This edited volume emphasizes how microorganisms have become a reliable pillar of biotechnology. The authors discuss advances in synthetic biology and genetic engineering that have made it possible to reprogram the microbial cellular capabilities. This enables an economically viable production of high-value products at an industrial level. The first part of the book provides an overview of synthetic biology and genome editing tools for engineering microbial cell factories in modern fermentation. Readers also learn how high-throughput bioprocessing methods are used to recover and purify microbial products. The remaining parts of this book explore the implementation and challenges of these upstream and downstream processing techniques for manufacturing high-value products. Cost-effectiveness and quality-control are key factors, when discussing the production of low-molecular-weight products, biopharmaceuticals, biopolymers and protein-based nanoparticles. This book is a valuable resource for biotechnologists both in the industry and in academia.

Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production. Recent Advances in Biotechnology is a book series comprising of peer-reviewed reference works and monographs that compile the latest developments in the field of biotechnology. Each volume has a thematic focus and features topical reviews written by experts. The series will highlight multidisciplinary perspectives to interested readers (biotechnologists, microbiologists, bioprocess engineers, agronomists, medical professionals, sustainability researchers etc.)

Encyclopedia of Renewable and Sustainable Materials, Five Volume Set provides a comprehensive overview, covering research and development on all aspects of renewable, recyclable and sustainable materials. The use of renewable and sustainable materials in building construction, the automotive sector, energy, textiles and others can create markets for agricultural products and additional revenue streams for farmers, as well as significantly reduce carbon dioxide (CO2) emissions, manufacturing energy requirements, manufacturing costs and waste. This book provides researchers, students and professionals in materials science and engineering with tactics and information as they face increasingly complex challenges around the development, selection and use of construction and manufacturing materials. Covers a broad range of topics not available elsewhere in one resource Arranged thematically for ease of navigation Discusses key features on processing, use, application and the environmental benefits of renewable and sustainable materials Contains a special focus on sustainability that will lead to the reduction of carbon emissions and enhance protection of the natural environment with regard to sustainable materials

This report reviews a number of hybrid technologies that can be deployed to ‘defossilise’ economic sectors and sets out policy options to bring these technologies to commercial scale.