Only recently was it determined that two of the world's most devastating plagues, the plague of Justinian and the medieval Black Death, were caused by distinct strains of the same pathogen. Use of paleomicrobiological techniques led to this discovery. This work is just one example of the historical mysteries that this emerging field has helped to clarify. Others, such as when tuberculosis began to afflict humans, the role of lice in plague pandemics, and the history of smallpox, are explored and further illuminated in Paleomicrobiology of Humans. Led by editors Michel Drancourt and Didier Raoult, the book's expert contributors address larger issues using paleomicrobiology. These include the recognition of human remains associated with epidemic outbreaks, identification of the graves of disasters, and the discovery of demographic structures that reveal the presence of an epidemic moment. In addition, the book reviews the technical approaches and controversies associated with recovering and sequencing very old DNA and surveys modern human diseases that have ancient roots. Essentially, paleomicrobiologists aim to identify past epidemics at the crossroads of different specialties, including anthropology, medicine, molecular biology, and microbiology. Thus, this book is of great interest not only to microbiologists but to medical historians and anthropologists as well. Paleomicrobiology of Humans is the first comprehensive book to examine so many aspects of this new, multidisciplinary, scientific field.

This fascinating new volume comes complete with color illustrations and features the methodology and main achievements in the emerging field of paleomicrobiology. It’s an area research at the intersection of microbiology and evolution, history and anthropology. New molecular approaches have already provided exciting results, such as confirmation of a single biotype of Yersinia pestis as the cause of historical plague pandemics. An absorbing read for scientists in related fields.

Fossil Parasites, the latest edition in the Advances in Parasitology series established in 1963, contains comprehensive and up-to-date reviews on all areas of interest in contemporary parasitology, including medical studies of parasites of major influence, such as plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. Parasitism is a dominant life history strategy and we know it has existed for millions of years. Detecting parasitism in the fossil record is problematic because we rarely see direct evidence and usually must rely on indirect evidence to infer its existence. This unique volume takes a broad and systematic view of direct and indirect evidence for parasitism in the fossil record. - Expert contributors providing timely reviews of different aspects of palaeoparasitology - Comprehensive treatments of taxonomic groups never before summarized - Comprehensive coverage of important historical and recent advances in the field - New avenues for research are explored and suggested

The Routledge Handbook of Paleopathology provides readers with an overview of the study of ancient disease. The volume begins by exploring current methods and techniques employed by paleopathologists as means to highlight the range of data that can be generated, the types of questions that can be methodologically addressed, our current limitations, and goals for the future. Building on these foundations, the volume introduces a range of diseases and conditions that have been noted in the fossil, archaeological, and historical record, offering readers a foundational understanding of pathological conditions, along with their potential etiologies. Importantly, an evolutionary and highly contextualized assessment of diseases and conditions will be presented in order to demonstrate the need for adopting anthropological, biological, and clinical approaches when exploring the past and interpreting the modern world. The volume concludes with the contextualization of paleopathological research. Chapters highlight ways in which analyses of health and disease in skeletal and mummified remains reflect political and social constructs of the past and present. Health and disease are tackled within evolutionary perspectives across deep time and generationally, and the nuanced interplay between disease and behavior is explored. The volume will be indispensable for archaeologists, bioarchaeologists, and historians, and those in medical fields, as it reflects current scholarship within paleopathology and the field’s impact on our understanding of health and disease in the past, the present, and implications for our future.

Bioarchaeologists who study human remains in ancient, historic and contemporary settings are securely anchored within anthropology as anthropologists, yet they have not taken on the pundits the way other subdisciplines within anthropology have. Popular science authors frequently and selectively use bioarchaeological data on demography, disease, violence, migration and diet to buttress their poorly formed arguments about general trends in human behavior and health, beginning with our earliest ancestors. While bioarchaeologists are experts on these subjects, bioarchaeology and bioarchaeological approaches have largely remained invisible to the public eye. Current issues such as climate change, droughts, warfare, violence, famine, and the effects of disease are media mainstays and are subjects familiar to bioarchaeologists, many of whom have empirical data and informed viewpoints, both for topical exploration and also for predictions based on human behavior in deep time. The contributions in this volume will explore the how and where the data has been misused, present new ways of using evidence in the service of making new discoveries, and demonstrate ways that our long term interdisciplinarity lends itself to transdisciplinary wisdom. We also consider possible reasons for bioarchaeological invisibility and offer advice concerning the absolute necessity of bioarchaeologists speaking out through social media.

This monograph represents an expansion and deepening of previous works by Ole J. Benedictow - the author of highly esteemed monographs and articles on the history of plague epidemics and historical demography. In the form of a collection of articles, the author presents an in-depth monographic study on the history of plague epidemics in Scandinavian countries and on controversies of the microbiological and epidemiological fundamentals of plague epidemics.

A witty, irreverent tour of history's worst plagues—from the Antonine Plague, to leprosy, to polio—and a celebration of the heroes who fought them In 1518, in a small town in Alsace, Frau Troffea began dancing and didn’t stop. She danced until she was carried away six days later, and soon thirty-four more villagers joined her. Then more. In a month more than 400 people had been stricken by the mysterious dancing plague. In late-seventeenth-century England an eccentric gentleman founded the No Nose Club in his gracious townhome—a social club for those who had lost their noses, and other body parts, to the plague of syphilis for which there was then no cure. And in turn-of-the-century New York, an Irish cook caused two lethal outbreaks of typhoid fever, a case that transformed her into the notorious Typhoid Mary. Throughout time, humans have been terrified and fascinated by the diseases history and circumstance have dropped on them. Some of their responses to those outbreaks are almost too strange to believe in hindsight. Get Well Soon delivers the gruesome, morbid details of some of the worst plagues we’ve suffered as a species, as well as stories of the heroic figures who selflessly fought to ease the suffering of their fellow man. With her signature mix of in-depth research and storytelling, and not a little dark humor, Jennifer Wright explores history’s most gripping and deadly outbreaks, and ultimately looks at the surprising ways they’ve shaped history and humanity for almost as long as anyone can remember.

This volume describes different sequencing methods, pipelines and tools for metagenome data analyses. Chapters guide readers through quality control of raw sequence data, metagenomics databases for bacterial annotations such Greengenes, SILVA, RDP and GTDB, guide to 16S rRNA microbiome analysis and pipelines such as mothur, DADA2, QIIME2 , whole genome shotgun metagenomics data analyses pipeline using MEGAN and DIAMOND, web service such as PATRIC, RDP, mothur, Kaiju, PhyloPythiaS, MG-RAST, WebMGA, MicrobiomeAnalyst, WHAM!, METAGENassist and MGnify: EBI-Metagenomics, MG-RAST Metagenomics Analysis. Then the chapters inform the readers regarding Third-generation sequencing (TGS) approaches as MinION sequencing and teaches use of Ubuntu Linux Virtual Machine configuration, clinical and environmental resistomes, use of FISH techniques and designing FISH probes, protocols for viral metagenomics, and comprehensive guideline for microbiome analysis using most used R packages. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Metagenomic Data Analysis: Methods and Protocols aims to be comprehensive guide for researchers to specialize in the metagenomics field.

Advances in Virus Research, Volume 111, the latest release in a serial that highlights new advances in the field, presents interesting and timely chapters authored by an international board of subject matter experts. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Virus Research series