This book provides a broad overview of pancreatic neuroendocrine neoplasms, focusing on the most important developments in the technologies used to diagnose, classify and treat them. After a historical and epidemiological overview, the opening chapters examine the various diagnostic approaches (radiology, nuclear medicine, endocrinology, cytology and immunohistochemistry) and discuss the WHO classification. The functioning and nonfunctioning tumor types are then fully discussed, covering epidemiology, diagnosis, morphology and prognosis of each entity. Careful consideration is given to the molecular features that have contributed in understanding the pathogenesis of such neoplasms and may have potential implications for the diagnostic and therapeutic pathways. The final chapters consider the surgical and medical approaches to therapy, providing a practical and analytical overview of the available options. The book is written by a multidisciplinary team of worldwide-recognized experts and is addressed to radiologists, nuclear medicine physicians, endocrinologists, pathologists, surgeons and oncologists.

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. James Howe, is devoted to Management of GI and Pancreatic Neuroendocrine Tumors. Dr. Howe has assembled expert authors to review the following topics: Introduction and History of GI and Pancreatic Neuroendocrine Tumors (GEPNETs); Surgical Management of Colorectal Neuroendocrine Tumors; Management of Metastatic GEPNETs; Pathologic considerations in GEPNETs; Medical Management of GEPNETs; Workup of GEPNETs; Peptide Radioreceptor Therapy (PRRT); Surgical Management of Small Bowel Neuroendocrine Tumors; The Role of Functional Imaging in GEPNETs; Surgical Management of Pancreatic Neuroendocrine Tumors; Surgical Management of Other Gastric and Duodenal Neuroendocrine Tumors; and more!

This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.

This book is a comprehensive, state-of-the art, definitive reference for the surgical management of Neuroendocrine Tumors (NETs). It provides a practical, clinically useful guide that prioritizes the diagnostic work-up, indications for surgery, surgical principles, and perioperative care of patients with NETs in the context of multi-disciplinary care. Most textbooks on NETs have traditionally focused on patients with advanced disease, highlighting systemic therapies and emerging treatment options. In contrast, this book provides a concise yet comprehensive summary of the surgical management of NETs and serves as an invaluable resource for physicians, fellows, and residents who treat this difficult disease by providing helpful guidelines and up-to-date information on clinical management. Written by experts in the field, Neuroendocrine Tumors includes the most up-to-date clinical information from national and international leaders in their respective disciplines. It not only serves as an invaluable resource for many as they seek to provide the best possible surgical and multidisciplinary cancer care, but also an opportunity to identify new avenues of scientific discovery that may lead to significant advances in the diagnosis and management of NETs.

In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

This issue of Hematology/Oncology Clinics of North America is devoted to Neuroendocrine tumors. Articles in this issue include: Pathology Classification of Neuroendocrine Tumors; Clinical Presentation and Diagnosis of Neuroendocrine Tumors; Surgical Management of Gastrointestinal Carcinoid Tumors; Systemic Therapies for Advanced Gastrointestinal Carcinoid Tumors; Thymic and Bronchial Carcinoid Tumors; Surgical Management of Pancreatic Neuroendocrine Tumors; Systemic Therapies for Advanced Pancreatic Neuroendocrine Tumors; Pheochromocytoma and Paraganglioma; Poorly Differentiated Neuroendocrine Tumors; Role of Somatostatin Analogs in the Treatment of Neuroendocrine Tumors; Peptide Receptor Radiotherapy in the Treatment of Neuiroendocrine Tumors; Hepatic-Directed Therapies in Patients with Neuroendocrine Tumors; and Neuroendocrine Tumor Clinical Trial Interpretation and Design.

This comprehensive subspecialty reference book on NeuroEndocrine Tumor (NET) pathology brings together the diagnostic and clinical expertise of an outstanding team of practicing neuroendocrine pathologists and oncologists. In addition to in-depth coverage of clinico-pathologic aspects of NETs of the various organ systems, the recent histological grading and staging schemes proposed by the North American and European NeuroEndocrine Tumor Societies (NANETS, ENETS), the World Health Organization (WHO) and the American Joint Committee on Cancer (AJCC), this book also focuses on the recent molecular and therapeutic advances in the field of NET pathology and oncology. Neuroendocrine Tumors: Review of Pathology, Molecular and Therapeutic Advances will be an essential reference book for anatomic pathology (histopathology) residents, fellows, surgical pathologists, researchers, oncologists, surgeons and other medical professionals practicing advanced NET Pathology and Oncology in academia, community, private practice and research settings.

Our understanding of pancreatic tumors is changing thanks to recent advances in the field. New diagnostic techniques and imaging tests have improved the early diagnosis of these lesions, and as a result, the growing number of R0 surgical resections has meant a better prognosis for patients. Further, minimally invasive laparoscopic approaches have increased postoperative comfort. Presenting the latest research in the field, this book will appeal to clinicians in a wide range of medical specialities, including gastroenterologists, general physicians, and abdominal and biliopancreatic surgeons.