This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients

Accurate diagnosis of neurological disorders can often be difficult due to the complex nature of the nervous system. Whilst technological advances have greatly improved diagnostic and interpretation techniques, errors can still occur, which consequently result in mistakes in therapeutic care. This book is a guide to diagnostic strategies for a multitude of common and less common neurological disorders. Scenarios are set in both a clinical and an intensive care setting. Divided into 13 sections, the text begins with an overview of general neurology. Each of the following sections examines disorders in a different part of the nervous system. Diagnostic processes are evaluated and potential areas where a clinician may make a mistake, are examined and explained in depth. The final section presents 15 authentic cases covering diagnostic challenges in critical care units, all provided by leading experts from the University of Texas Southwestern Medical Centre, USA. With contributions from internationally recognised neurologists, this comprehensive text is highly illustrated with neurological images, and many chapters feature additional editorial notes and appendices. Access to a selection of clinical videos via a QR code is also provided with this book.

In this issue of Neurologic Clinics, guest editor Dr. Rima M. Dafer brings her considerable expertise to the topic of Neurological Disorders in Women: From Epidemiology to Outcome. Top experts in the field discuss the most common neurological conditions affecting women, including stroke, migraine, multiple sclerosis, and dementia, among others, with special consideration for the management of these conditions during reproductive years of age. - Contains 14 practice-oriented topics, including sex difference in Alzheimer's disease and other dementias; migraine and the gender divide; women and sleep disorders; sex differences in autism spectrum disorders; neurology of systemic disease: focus on women; gender differences in neurology training; and more. - Provides in-depth clinical reviews on neurological disorders in women, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In Cancer Neurology in Clinical Practice, leading neuro-oncologists from around the world comprehensively review the neurologic symptoms that cancer patients experience, and show how they should be interpreted and evaluated. Organized by both symptom and organ, the book carefully describes each diagnostic neurologic entity-from symptomatology to diagnostic studies to management and prognosis-and presents each major type of cancer in terms of it neurologic problems and how they should be handled. The role of surgery, radiation, chemotherapy, and other palliative measures are considered for each type of problem. Multidisciplinary and up-to-date, Cancer Neurology in Clinical Practice explains to the busy physicians treating cancer patients the latest findings in neuro-oncology that will help them to focus their differential diagnosis, diagnostic strategy, and treatment plan for the cancer patient with neurologic symptoms and findings.

The fourth edition of Motor Disorders reinforces the reputation gained by earlier editions. The book gives a detailed and practical account of motor disorders that will appeal to specialists as well as to general physicians and trainees while providing a convenient but thorough summary of advances in the field. The book brings together the entire spectrum of motor disorders and thereby aids in the evaluation, diagnosis, and distinction of these various disorders. Through the perspectives of many subspecialties, this book provides accounts of all disorders with motor manifestations, providing a truly comprehensive but concise account of the subject matter.

Perfect for residents, medical students, generalists, nurses, and other healthcare professionals who need a practical, working knowledge of neurology, Netter's Neurology, 3rd Edition, provides a concise overview highlighted by unique, memorable Netter illustrations. This award-winning visual resource showcases the well-known work of Frank H. Netter, MD, and his successor, Carlos Machado, MD, a physician who has created clear, full-color illustrations in the Netter tradition. - Offers a quick and memorable summary of general neurology and its intersection with internal medicine, neurosurgery, ophthalmology, psychiatry, and orthopaedics. Concise text is presented in a templated format for fast, easy access to information. - Features more than 450 Netter and Netter-style images that highlight anatomy, pathophysiology, and clinical presentation related to neuroanatomical and neurologic concepts. - Helps you make correlations between anatomy, pathology, physiology, and pharmacology in a clinical setting. Clinical vignettes throughout provide real-world applications to each topic. - Features new chapters on Laboratory Evaluation in Neurology; Neuroimaging in Neurologic Disorders; and Neurologic Emergencies and Critical Care. - Presents the underlying anatomy in living patients through neuroimaging coverage, including MR, CT, and PET.

Paraneoplastic syndromes, defined in this book as "disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue", once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers. This book attempts a comprehensive review of paraneoplastic syndromes from considering both clinical and pathophysiologic aspects. The book is divided into 4 sections: The first is an overview, classifying the disorders, describing a clinical approach to the diagnosis and treatment of paraneoplastic syndromes in general and identifying their pathogenesis. The section discusses the clinical findings and treatment of individual paraneoplastic syndromes with chapters dedicated to each of the neurologic syndromes and a chapter discussing nonneurologic syndromes such as endocrine, cutaneous, and rheumatologic paraneoplastic disorders. The third section discusses autoantibodies that characterize individual paraneoplastic syndromes. The final section discusses the paraneoplastic syndromes associated with individual cancers.

Neurologists present their own experiences and step-by-step guidelines on the management and treatment of specific disorders affecting the nervous system. Diagnosis, epidemiology, and pathophysiology are discussed only when they affect treatment strategies and decisions. Treatment algorithms and patient resource information complement each chapter.

Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients.This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases.Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complicatio