Over the last few years there have been huge advances made in our understanding of the interactions between the brain and the gut – the enteric nervous system. This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in 10-20% of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. This book is aimed at specialist gastroenterologists but also should be of interest for trainees and fellows in gastroenterology, as well as PCPs and GPs with an interest in this subject.

FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tractto collect in one set of volumes the most current and comprehensive knowledge in our fieldwas also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology· Information presented in a style that is both readable and understandable· Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student· Features an entirely new section on Immunology and Inflammation· Each section edited by the preeminent scientist in the field

Gain a foundational understanding of gastrointestinal physiology and how the GI system functions in health and disease. Gastrointestinal Physiology, a volume in the Mosby Physiology Series, explains the fundamentals of this complex subject in a clear and concise manner, while helping you bridge the gap between normal function and disease with pathophysiology content throughout the book. - Helps you easily master the material in a systems-based curriculum with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, self-study questions, and a comprehensive exam. - Keeps you current with recent advances in gastrointestinal physiology with coverage of the physiological significance of gastrointestinal peptides; the regulation of mucosal growth and cancer; details surrounding acid secretion and peptic ulcers; and more. - Includes clear, 2-color diagrams that simplify complex concepts. - Features clinical commentaries that show you how to apply what you've learned to real-life clinical situations. - Covers the regulation of pancreatic secretion and gallbladder contraction; the transport processes for the absorption of nutrients; facts about fat absorption; and the regulation of food intake. Complete the Mosby Physiology Series! Systems-based and portable, these titles are ideal for integrated programs. - Blaustein, Kao, & Matteson: Cellular Physiology and Neurophysiology - Cloutier: Respiratory Physiology - Koeppen & Stanton: Renal Physiology - Pappano & Weir: Cardiovascular Physiology - White, Harrison, & Mehlmann: Endocrine and Reproductive Physiology - Hudnall: Hematology: A Pathophysiologic Approach

Researchers and educators agree that it takes more than academic knowledge to be prepared for college—intrapersonal competencies like conscientiousness have been proven to be strong determinants of success. WileyPLUS Learning Space for Anatomy & Physiology helps you identify students' proficiency early in the semester and intervene as needed. Developed for the two-semester course, Anatomy & Physiology is focused on aiding critical thinking, conceptual understanding, and application of knowledge. Real-life clinical stories allow for a richer investigation of content, ensuring that students understand the relevance to their lives and future careers.

Comprehensive Human Physiology is a significantly important publication on physiology, presenting state-of-the-art knowledge about both the molecular mechanisms and the integrative regulation of body functions. This is the first time that such a broad range of perspectives on physiology have been combined to provide a unified overview of the field. This groundbreaking two-volume set reveals human physiology to be a highly dynamic science rooted in the ever-continuing process of learning more about life. Each chapter contains a wealth of original data, clear illustrations, and extensive references, making this a valuable and easy-to-use reference. This is the quintessential reference work in the fields of physiology and pathophysiology, essential reading for researchers, lecturers and advanced students.

Physiology of the Gastrointestinal Tract, Fifth Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine — covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. - 2013 Highly Commended BMA Medical Book Award for Internal Medicine - Discusses the multiple processes governing gastrointestinal function - Each section edited by preeminent scientist in the field - Updated, four-color illustrations

A system- and disease-based approach to the aspects of gastrointestinal pathophysiology, essential for an understanding of clinical medicine. Bridging the gap between basic science and clinical medicine, this text provides students with a solid understanding of symptom identification and the underlying disease mechanism. Features clinical pearls, learning objectives, study questions, algorithms, and key concepts highlighting the presentation in each chapter.

The Multifunctional Gut of Fish provides a comprehensive synthesis and an integrative overview of the range of gut functions and their implications for organismal physiology. The highly diversified anatomy and functions of the gut, including nutrient uptake, immune barrier function, salt and water homeostasis and respiration, as well as neuroendocrine actions and control are covered in detail by leading authors. In addition, this volume explores the pronounced implications of gut function for whole animal integrative physiology and compensatory demands for non-gastrointestinal organs. As the first comprehensive reference to discuss the diverse morphological and functional adaptations of the gut, this volume provides an excellent resource for comparative physiologists, aquaculturists and biomedical researchers employing fish as model organisms for mammalian physiology. - Includes chapters dedicated to anatomical and functional features of the gastro-intestinal tract of fish as well as integrative aspects of gut organ function - Includes in depth coverage of recently recognized implications of feeding on salt homeostasis and acid-base balance - Provides syntheses of implications of gut function for homeostasis - Essential text for those interested in the wide diversity of functions performed by the gut

Now in its Third Edition, this text clearly and concisely presents the physiological principles that are essential to clinical medicine. Outstanding pedagogical features include Active Learning Objectives that emphasize problem-solving applications of basic principles; conceptual diagrams that help students visualize complex processes; case studies, Clinical Focus boxes, and From Bench to Bedside boxes; a comprehensive glossary; and online USMLE-style questions with answers and explanations. This edition features a new Immunology and Organ Function chapter and a completely rewritten and reorganized cardiovascular section. A companion Website will include the fully searchable text, an interactive question bank, case studies with practice questions, animations of complex processes, an image bank, and links for further study.