Positron emission tomography (PET) has been at the forefront of fu- tional and molecular imaging for a number of years. The future of di- nostic imaging depends upon the ability to change from imaging anatomy to examining the processes at work in the body. The fact that there are now monographs examining particular aspects of PET, such as this book on the examination of children, speaks to the newly won maturity of PET. The authors are to be congratulated for the timely appearance of this volume. In recent years, PET has transformed the contributions of nuclear medicine to the diagnosis, staging, and follow-up of patients with cancer. Children with cancer deserve the very best and most comp- sionate care that society can provide. Ultimately the greatest comp- sion we can offer as physicians is to provide the best possible care. Those charged with creating public policy in the context of diagnostic medicine must make common cause with physicians and other sci- tists to ensure that that best possible care is realized at the bedside. All of the evidence suggests that PET is central to such optimal cancer care. In addition to the distinguished cast of physicians and researchers who contributed to this book, I welcome the contributions from te- nologists who are a key part of the interaction between the diagnostic process and the sick or potentially sick child. Good care is contingent upon putting parents and child at ease, and the technologist has a lead role in this.

This issue of PET Clinics focuses on PET Imaging in Pediatric Patients and is edited by Drs. Hongming Zhuang and Abass Alavi. Articles will include: Promising New PET tracers in the evaluation of pediatric disease; F-DOPA PET/CT in the management of congenital hyperinsulinism; Emerging roles of PET/MRI in pediatric hospital; Roles of FDG PET/CT in the management of posttransplant lymphoproliferative disease in pediatric patient; FDG-PET/CT in the management of pediatric lymphoma; Preparation and logistic consideration in performing PET/CT and PET/MRI in pediatric patients; PET/CT in the evaluation of FUO and infectious/inflammatory disease in pediatric patients; Roles of PET/CT in the evaluation of neuroblastoma; Potential Roles of Total Body Imaging in Pediatric Diseases and Disorders; PET/CT in the Management of Pediatric Sarcomas; Pediatric Cardiac PET Imaging; Dosimetry between PET/CT and PET/MRI: Implications in Pediatric Imaging; Essential Role of Global Disease Assessment in Assessing Systemic Disorders, and more!

This pioneering book, now in its fourth edition, presents the cutting-edge developments in pediatric nuclear medicine. Thoroughly revised and updated, it retains the fundamentals that anchor the book’s distinguished reputation and includes the latest advances in PET/CT, SPECT, hybrid imaging, and molecular imaging. Pediatric Nuclear Medicine and Molecular Imaging, Fourth Edition, is an excellent resource for nuclear medicine physicians, diagnostic radiologists, pediatricians, and residents and fellows. The Fourth Edition features: · 16 new chapters, including PET and PET/CT in Children and Young Adults; Lymphoscintigraphy; Skeletal Scintigraphy; Neuroblastoma; Lymphomas and Lymphoproliferative Disorders; Functional Imaging of Pediatric Musculoskeletal Tumors; Solid Tumors in Childhood; Pediatric Molecular Imaging; Combined PET/MRI in Childhood; Radiation Exposures; Radiation Protection in Pediatric Nuclear Medicine; and Dose Optimization in Pediatric Nuclear Medicine. · Discussion of the use of image fusion and hybrid imaging in children. · Strategies for communicating potential radiation risk to patients, families and members of the healthcare team. · Methods to optimize pediatric radiopharmaceutical administered doses and improve image quality. S. Ted Treves, MD, is Professor of Radiology at Harvard Medical School, Founder and Former Chief, Division of Nuclear Medicine and Molecular Imaging, Ch ildren’s Hospital Boston (1970-2011). In 2013, he received the Society of Nuclear Medicine and Molecular Imaging’s Georg Charles de Hevesy Nuclear Pioneer Award for outstanding contributions to the field of Nuclear Medicine.

This issue of PET Clinics examines normal variations and benign findings in FDG PET/CT Imaging. Topics include Standardization and quantification in FDG PET /CT imaging for staging and restaging of disease, dynamic changes in FDG update in normal tissues, as well as normal variations in the brain, head and neck, thorax, abdomen, pelvis, and in pediatrics.

This book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.

This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

This issue of MRI Clinics of North America focuses on Pediatric MR Imaging, and is edited by Dr. Edward Y. Lee. Articles will include: MRI Evaluation of Pediatric Neck Masses: Review and Update; MRI of Lungs and Airways in Children: Past and Present; Pediatric Mediastinal Masses: Role of MRI As a Problem-Solving Tool; Pediatric Cardiac MRI: Practical Preoperative Assessment; Hepatobiliary MRI in Children: Up-To-Date Imaging Techniques and Findings; Pediatric Renal Neoplasms: MRI-Based Practical Diagnostic Approach; MRI Evaluation of Inflammatory Bowel Disease in Children: Where Are We Now in 2018?; MRI Evaluation of Pediatric Genital Disorders: MR Technology Overview and Interpretation; Pediatric Sport-related Injuries: An Imaging Overview for Current and Future Daily Practice; MRI of Pediatric Musculoskeletal Tumors: Recent Advances and Clinical Applications; MRI Evaluation of Pediatric Lymphatics: Overview of Techniques and Imaging Findings; PET-MRI: Current Updates on Pediatric Applications; Tales from the Night: Emergency MRI in Pediatric Patients after Hours; and more!

This practical guide is a reference source of cases for images obtained on state-of-the-art integrated PET/CT and SPECT/CT imaging systems. It covers the full spectrum of clinical applications, including head and neck tumors, breast cancer, colorectal cancer, pancreatic cancer, and genitourinary tumors. In addition a wealth of illustrations reinforce the key teaching points discussed throughout the book.

This issue provides a complete update on PET imaging of lymphoma, starting with a clinical assessment of lymphoma and the role of medical imaging. The role of structural imaging in lymphoma is then discussed. From a Nuclear Medicine perspective, FDG-PET in lymphoma is reviewed, as is the role of FDG-PET in pediatric lymphoma. Next, the role of non-FDG tracers in lymphoma is reviewed. Other articles cover the role of fMRI and optical imaging in lymphoma, the role of diffusion-weighted MRI in lymphoma, FDG-PET in personalization of therapy in patients with lymphoma, and PET and radiation oncology in lymphoma.

The technique for successfully completing a PET procedure is complex and involves a knowledge of physics, pharmacy, anatomy, physiology, and the disease process; applying PET scanning to children is even more challenging and technically demanding. One cannot simply adopt the approach used for adults but instead must receive specialized training in order to master pediatric PET procedures. This one-of-a-kind, interdisciplinary book is one of the first practical guides to imaging children with PET. The text opens with a section that focuses on practical and technical issues of pediatric PET imaging, including radiation dose and sedation. Principles of operation, instrumentation, and nuclear medicine regulations are also discussed. Subsequent sections cover the clinical applications of PET in pediatrics. With contributions from leading international authorities in the field, each chapter is heavily illustrated and provides the reader with extensive coverage of the essentials of clinical PET studies in oncology and neurology, which standout as key areas for PET imaging in pediatrics.