This volume is based on a highly successful conference dedicated to “Perinatal brain damage:from pathogenesis to neuroprotection ”. Neonatologists, paediatricians, paediatric neurologists, obstetricians, basic researchers involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication. The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup and treatment.The most authoritative basic researchers, clinicians, and specialists in the field of neuroimaging, provide chapters on recent clinical advances. A subject of particular importance is the neurological vulnerability of the preterm infant, which also touches on ethical aspects of the care of high-risk preterm babies and those born from multiple pregnancies. A particularly original session focuses on cerebral white matter and the many issues related to this crucial part of the developing brain. Experts also deal with cerebral visual impairment, motor development, cognitive function, and the mechanisms underlying the neuronal plasticity of the infant’s brain. Concepts of neuroprotection are also outlined, based on pharmacological agents tested on experimental animals and the best drugs used to treat neonatal convulsions.

This book focuses on traumatic birth injuries, predominantly of the skull and brain, as well as hemorrhagic and ischemic disorders of cerebral circulation in fetuses and newborns, providing information on each condition’s classification, incidence, etiology and pathogenesis, pathomorphology, clinic, diagnostics, prognosis, and complications. It discusses the configuration (molding) of the head, venous congestion, displacements of cranial bones, ruptures of the cerebellar tentorium during labor, and the compression of the skull and brain damage caused by obstetric operations and asynclitic insertion of the head, while also describing the importance of the periosteal stagnation of the skull to assess the delivery and explanation of tentorium tears. Intracranial hemorrhages are considered in detail, taking into account the role of the traumatic factor in their occurrence and hypoxic-ischemic brain lesions (periventricular leukomalacia, selective neuronal necrosis, multicystic encephalomalacia, etc.). Lastly, it offers the world’s first explanation of why tentorium tears occur most frequently in the left half, providing an original classification of damaged tentoria, subarachnoid and intraventricular hemorrhages, and the degree of configuration of the head in childbirth. Given the depth and breadth of its coverage, the book offers an essential resource for neonatologists, obstetricians-gynecologists, perinatologists, pediatric neurologists, pathologists, pediatricians, forensic experts and neuroimaging professionals.

Decision making in modem obstetrics and perinatology is con trolled by a variety of different factors, but there is little doubt that in industrialized countries one of the most powerful single factors is the concern and fear of causing permanent brain damage in the unborn and newborn. The dramatic increase in the rates of abdom inal deliveries in many parts of the world is certainly rooted to a substantial part in the ~bstetrician's concern not so much about possible perinatal death, but more so about permanent brain dam age in surviving children. This trend has been accelerated by the increasing number of litigations in connection with brain damage observed in many societies. This problem itself has many aspects, but it seems evident that litigation - justified or unjustified - is one modem expression of the human and social tragedy inflicted on individuals and families by the birth of a brain-damaged child. The medical, social, and human importance of the problem is in sharp contrast to the relative lack of scientific knowledge avail able. This became very clear when the National Institutes of Health published the excellent review in 1985 on "Prenatal and Perinatal Factors Associated with Brain Disorders" and its editor, J. M.

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Cognition, Brain, and Consciousness, Second Edition, provides students and readers with an overview of the study of the human brain and its cognitive development.It discusses brain molecules and their primary function, which is to help carry brain signals to and from the different parts of the human body. These molecules are also essential for understanding language, learning, perception, thinking, and other cognitive functions of our brain. The book also presents the tools that can be used to view the human brain through brain imaging or recording.New to this edition are Frontiers in Cognitive Neuroscience text boxes, each one focusing on a leading researcher and their topic of expertise. There is a new chapter on Genes and Molecules of Cognition; all other chapters have been thoroughly revised, based on the most recent discoveries.This text is designed for undergraduate and graduate students in Psychology, Neuroscience, and related disciplines in which cognitive neuroscience is taught. - New edition of a very successful textbook - Completely revised to reflect new advances, and feedback from adopters and students - Includes a new chapter on Genes and Molecules of Cognition - Student Solutions available at http://www.baars-gage.com/ For Teachers: - Rapid adoption and course preparation: A wide array of instructor support materials are available online including PowerPoint lecture slides, a test bank with answers, and eFlashcords on key concepts for each chapter. - A textbook with an easy-to-understand thematic approach: in a way that is clear for students from a variety of academic backgrounds, the text introduces concepts such as working memory, selective attention, and social cognition. - A step-by-step guide for introducing students to brain anatomy: color graphics have been carefully selected to illustrate all points and the research explained. Beautifully clear artist's drawings are used to 'build a brain' from top to bottom, simplifying the layout of the brain. For students: - An easy-to-read, complete introduction to mind-brain science: all chapters begin from mind-brain functions and build a coherent picture of their brain basis. A single, widely accepted functional framework is used to capture the major phenomena. - Learning Aids include a student support site with study guides and exercises, a new Mini-Atlas of the Brain and a full Glossary of technical terms and their definitions. - Richly illustrated with hundreds of carefully selected color graphics to enhance understanding.

This authoritative resource is ideal for those caring for patients wit h traumatic brain injury (TBI) and mental retardation (MR) syndromes. The text is structured in an easy to follow format: five chapters on b rain injury syndromes, five chapters on mental retardation syndromes, four chapters devoted to other neuropathic conditions that are common to both, and six chapters that feature the drugs and how to use them. The drug section is tailored to the psychiatric disorders relevant to these specific patient populations.

This is a large, all-inclusive reference volume of 67 chapters documenting the very latest experimental and clinical advances in perinatal medicine by world-class experts in the field. It covers fetal anomalies, intrauterine growth and parturition, maternal and infant nutrition, the very low birthweight infant, ultrasound for fetal and neonatal assessment, environmental influences on the embryo and fetus, maternal disease and pregnancy outcome, pre- and perinatal diagnosis and management of inherited metabolic diseases, protection of the fetal/infant brain, investigation and treatment and outcome for fetal abnormalities, perinatal nursing care and perinatal transport, perinatal medicine and professional education in Europe, perinatal cardiorespiratory support, ethics and audit and medicolegal aspects of perinatal practice in Europe, prevention of preterm deliveries, fetal and in-fant learning and behavior, biotechnology and perinatal research, surfactant replacement therapy, and matters of special controversy. Includes bibliographic references and index.

Provides the insights in neonatal neurology. This title describes from the discoveries in genetics through the advances in the diagnosis and management of neurologic disorders. It delivers clinical guidance you need to provide effective care for neonates with neurological conditions.

Haemorrhage, Ischaemia and the Perinatal Brain focuses on an area of major importance in perinatal medicine. The authors, who have both made significant contributions to the subject of cerebral haemorrhage in the newborn, put forward many new and unpublished ideas throughout this monograph. By presenting a synopsis of current knowledge on all aspects of the haemorrhagic and ischaemic lesions affecting the newborn brain, they aim to provide the clinician with a logical basis for management of these devastating conditions and attempts at their prevention. The influence of altered cerebral circulatory physiology on the developing vasculature is emphasized as the key to understanding the patterns of pathology that occur at different gestational ages. A feature of the book is the chapter on vascular anatomy of the developing brain, which contains extensive new and original work illustrated in colour. Cerebral circulatory physiology, birth trauma, ischaemic lesions of the preterm and term brain damage all receive coverage, in addition to a comprehensive series of chapters on intraventricular haemorrhage. Sections on clinical management are illustrated by radiographs and CT scans from the Department of Radiology, Hospital for Sick Children, Toronto, and there are original line drawings by the authors throughout the book. Although intended primarily for the paediatrician, this book should also be of particular interest to pathologists, obstetricians and all whose work is concerned with perinatal care.