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BOOK EXCERPT:
Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. - Allows readers to systematically integrate up-to-date research findings into their laboratory work - Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment - Provides clinical applications of concepts
Product Details :
Genre |
: Medical |
Author |
: Rakesh Kumar Tekade |
Publisher |
: Academic Press |
Release |
: 2022-02-05 |
File |
: 816 Pages |
ISBN-13 |
: 9780323913164 |
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BOOK EXCERPT:
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research. - Examines toxicological risk assessment in drug research - Discusses toxicity mechanisms - Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology - Offers clinical interventions and managed care as a result of toxic injury and acute poisoning
Product Details :
Genre |
: Medical |
Author |
: Rakesh Kumar Tekade |
Publisher |
: Elsevier |
Release |
: 2023-03-23 |
File |
: 754 Pages |
ISBN-13 |
: 9780443158414 |
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BOOK EXCERPT:
Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health. Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments. - Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health - Examines the toxic effects of medical treatments, clinical administrations, and materials - Explores public health issues around drug safety and toxicology
Product Details :
Genre |
: Medical |
Author |
: Rakesh Kumar Tekade |
Publisher |
: Elsevier |
Release |
: 2024-03-26 |
File |
: 854 Pages |
ISBN-13 |
: 9780443158438 |
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BOOK EXCERPT:
From Theory of Knowledge Management to Practice is a collaborative compilation featuring contributions from various authors. The book amalgamates analytical principles with the practical aspects of knowledge management in the business realm. Its unique contribution lies in bridging the gap between engineering/technology disciplines and the organizational, administrative, and planning dimensions of knowledge management. This integration is particularly valuable when viewed in conjunction with other sub-disciplines like economics, finance, marketing, and decision and risk analysis, among others. The book not only introduces but also illustrates knowledge management theories through practical case studies. These case studies showcase significant outcomes across different sectors, drawing on diverse real-world scenarios. The theoretical framework is accompanied by relevant analytical techniques, adopting a progressive approach that transitions from basic concepts to intricate and dynamic decision-making processes involving multiple data points, including big data and extensive datasets. The integration of computational techniques, dynamic analysis, probabilistic methods, and mathematical optimization further enhances the book's utility, offering expert support for the analysis of multi-criteria decision-making problems characterized by specific constraints and requirements.
Product Details :
Genre |
: Business & Economics |
Author |
: Fausto Pedro García Márquez |
Publisher |
: BoD – Books on Demand |
Release |
: 2024-01-31 |
File |
: 278 Pages |
ISBN-13 |
: 9781837694228 |
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BOOK EXCERPT:
Product Details :
Genre |
: |
Author |
: Ranbir Chander Sobti |
Publisher |
: Springer Nature |
Release |
: |
File |
: 770 Pages |
ISBN-13 |
: 9789819937462 |
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BOOK EXCERPT:
Product Details :
Genre |
: |
Author |
: |
Publisher |
: Food & Agriculture Org. |
Release |
: |
File |
: 200 Pages |
ISBN-13 |
: 9789251389836 |
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BOOK EXCERPT:
The Handbook of Green and Sustainable Nanotechnology presents sustainable and green technologies for the development of products and processes which are environmental friendly, economically sustainable, safe, energy-efficient, decrease waste and diminish greenhouse gas emissions. It provides the overall spectrum of fundamentals, development and applications of sustainable and green technologies. Topics such as legal, health and safety issues are discussed as well. The book elucidates paths to real time utilization of green and sustainable nanotechnology at commercial scale.
Product Details :
Genre |
: Technology & Engineering |
Author |
: Uma Shanker |
Publisher |
: Springer Nature |
Release |
: 2023-05-27 |
File |
: 2759 Pages |
ISBN-13 |
: 9783031161018 |
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BOOK EXCERPT:
Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: • Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems • Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index • Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials
Product Details :
Genre |
: Medical |
Author |
: Narayanaswamy Balakrishnan |
Publisher |
: John Wiley & Sons |
Release |
: 2014-06-16 |
File |
: 953 Pages |
ISBN-13 |
: 9781118595961 |
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BOOK EXCERPT:
Product Details :
Genre |
: Administrative law |
Author |
: |
Publisher |
: |
Release |
: 1994-03 |
File |
: 1214 Pages |
ISBN-13 |
: UIUC:30112059136694 |
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BOOK EXCERPT:
Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991
Product Details :
Genre |
: Medical |
Author |
: A. Yacobi |
Publisher |
: Springer Science & Business Media |
Release |
: 2013-11-11 |
File |
: 266 Pages |
ISBN-13 |
: 9781475715200 |