Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.

This two volume set is a comprehensive guide to neurosurgery. Each section covers neurological disorders in different parts of the body, beginning with an introduction and ending with key practice points for quick review, integrating theory and practice. Genetics, ethics and physiotherapy are also discussed. With contributions from recognised specialists in the USA and Europe, this practical manual includes more than 1000 images and illustrations to assist learning and understanding. Key Features Comprehensive two volume set giving complete review of field of neurosurgery Covers numerous neurological disorders in different parts of the body Each section feature key practice points for quick review Integrates theory and practice More than 1000 images and illustrations Contributions from US and European specialists

Traumatic Brain and Spinal Cord Injury comprehensively covers the medical and pathological issues related to neurotrauma and its often devastating consequences. Written by globally renowned experts in the field, both clinicians and researchers will find this book invaluable to update their knowledge. This volume is divided into two sections, one covering the brain, the other the spinal cord. Each section discusses the following topics: • The demographic in the developed and developing world where neurotrauma is witnessing a massive expansion • Major clinical issues including advanced semi-experimental monitoring techniques utilized by neurosurgeons and intensivists and the potential use of identifying markers of tissue injury • Overview of major pathophysiological changes • The development of animal models; successes and limitations • Past, current and future therapeutic strategies including rehabilitative opportunities. Presenting the most up-to-date clinical and experimental research in neurotrauma, this volume is essential reading for neurologists, neurosurgeons, intensive care physicians and rehabilitative physicians.

Build a solid foundation of knowledge based on the fundamentals and employ step-by-step instruction from Spine Surgery. Edited by Edward C. Benzel, this best-selling medical reference explores the full spectrum of surgical techniques used in spine surgery and delivers the comprehensive, cutting-edge guidance you need to achieve successful outcomes. Online access, thorough updates, contributions by leading international authorities, an abundance of detailed illustrations, and procedural video clips provide everything you need to avoid and manage complex problems. Glean essential, up-to-date, need-to-know information in one comprehensive reference that explores the full spectrum of surgical techniques used in spine surgery. Hone your surgical skills and technique with intraoperative videos and more than 800 outstanding illustrations demonstrating each technique step by step. Grasp and apply the latest knowledge from more than 25 brand-new chapters, as well as extensive revisions or total rewrites to the majority of existing chapters to present all of the most up-to-date information available on every aspect of spine surgery including motion preservation technologies, endovascular management, back pain and psychosocial interactions, biomechanics, and more. Consult with the best. Renowned neurosurgery authority Edward C. Benzel leads an international team of accomplished neurosurgeons and orthopedic surgeons - many new to this edition - who provide dependable guidance and share innovative approaches to surgical techniques and complications management. Equip yourself to address increasing occurrences of pain among aging and physically active patients. Access the information you need, where you need it on your laptop or mobile device via expertconsult.com, with fully searchable text, a wealth of procedural videos, online updates from the experts, downloadable image gallery and links to PubMed.

Regenerative engineering, with its ability to foster novel therapeutic techniques and strategies, has emerged as the most versatile and innovative technology of the 21st century. The past few years have seen a significant interest in the development of injectable hydrogels as a delivery system to realize the dream of regenerative engineering. The book will explain synthetic approaches towards developing injectable hydrogels, and the clinical implications and applications of injectable hydrogels for engineering various tissues. Injectable Hydrogels for Regenerative Engineering is the first of its kind to bring together the fields of injectable hydrogels and regenerative engineering to give a perspective of the emerging therapeutic strategies for a wide audience.

Brody's Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives. What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals. - Contains all the essential aspects of pharmacology – suitable for exam preparation - Full color illustrations explain important processes and color-coded boxes enhance understanding - Therapeutic overviews, clinical problems and trade names – everything you need to know - Self-assessment questions and further reading to reinforce learning - Current developments for each class of drugs and how information relates to students in the healthcare professions bring learning to life - Updated content throughout - Pharmacodynamics chapter revised to include discussions of positive and negative allosteric modulators, as well as biased agonism - Pharmacogenetics chapter considers genetic variations and their relationship to drug responses - Section on cancer drugs revised to reflect major advances - New chapter on immunological and cell-based therapies

The critical care management of patients with life-threatening neurological conditions requires the ability to treat neurological injuries, manage medical complications and perform invasive procedures whilst balancing the management of the brain and the body. The Oxford Textbook of Neurocritical Care provides an authoritative and up-to-date summary of the scientific basis, clinical techniques and management guidelines in this exciting clinical discipline. This highly authoritative textbook is conceptually divided into three sections. Section 1 provides an accessible guide to the general principles of neurophysiology and neuropharmacology, cardiorespiratory support, management of fluids and intracranial hypertension. Section 2 outlines the use of multiple monitoring modes which are crucial to diagnosis and management. Section 3 covers the management of the major pathologies encountered during neurointensive care with an emphasis on evidence-based practice or consensus guidelines to provide a cohesive and definitive clinical resource. Authored by an international team of expert practitioners this textbook reflects world-wide practice and guidelines. This volume is published with a concurrent online version, which features access to the full content of the textbook, contains links from the references to primary research journal articles, allows full text searches, and provides access to figures and tables that can be downloaded to PowerPoint ®. Designed for consultants and trainees in neurocritical care, The Oxford Textbook of Neurocritical Care is also accessible to the general critical care physician and trainees who need a definite and authoritative resource to meet the unique needs of neurocritically ill patients.