A distinguished international panel of authors define our current understanding of neuronal damage after ischemia and critically review the significant recent developments and progress in cerebrovascular accident (CVA) drug trials, both in animal models and in the clinical setting. These leading basic and fundamental authorities survey such important new drugs as calcium-influx inhibitors, free-radical scavenging drugs, glutamate and glycinergic antagonists, and immune suppressors. They also evaluate all the latest findings concerning calcium homeostasis, glutamate toxicity, gene activation, and the role of free radicals, glycine, and hormones. Chapters devoted to the neuroimaging of stroke, clinical trials, and the role of cerebral immune activation complete this informative collection of cutting-edge reviews.

The study of pharmacological actions of drugs in the brain is a field that constantly uncovers new insights into the mechanisms of action behind various substances. This proposal aims to explore into the intriguing topics of psychedelics, cannabinoids, classical and novel antidepressants, anxiolytic treatments, and substances commonly associated with neuropsychiatric disorders such as alcohol, ketamine, and opiates. The ultimate goal is to unravel their neurological impacts, shed light on potential therapeutic applications, and explore their relationship with brain disorders, while also investigating the influence of sex/gender on drug response. Biological differences between sexes can influence how medications are metabolized and processed in the body. Understanding these relationships and considering hormonal factors is crucial for optimizing treatment outcomes and tailoring medication regimens to individual needs.

This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. - Contributions from the best authors in the field - An essential resource for pharmacologists, immunologists, and biochemists

Stroke is the third leading cause of death in the USA and UK. It is a major cause of disability among adults and is a significant factor in dementia in later life and its incidence is on the rise. This book discusses specific medications that target the blood and vasculature and how these treatments can be used to complement other therapeutic measures, such as carotid endarterectomy. It covers the pharmacological methods used to address the risk factors in stroke, the major drug discoveries of recent years--antiaggregant, antithrombotic, and anticoagulant therapies--and also long established therapies such as aspirin and warfarin. With contributions by internationally recognized experts, this is a unique single source of information on current pharmacological prevention of stroke.

First multi-year cumulation covers six years: 1965-70.

PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries.