Postoptimal Analyses, Parametric Programming, and Related Topics: Degeneracy, Multicriteria Decision Making Redundancy.

The standard view of Operations Research/Management Science (OR/MS) dichotomizes the field into deterministic and probabilistic (nondeterministic, stochastic) subfields. This division can be seen by reading the contents page of just about any OR/MS textbook. The mathematical models that help to define OR/MS are usually presented in terms of one subfield or the other. This separation comes about somewhat artificially: academic courses are conveniently subdivided with respect to prerequisites; an initial overview of OR/MS can be presented without requiring knowledge of probability and statistics; text books are conveniently divided into two related semester courses, with deterministic models coming first; academics tend to specialize in one subfield or the other; and practitioners also tend to be expert in a single subfield. But, no matter who is involved in an OR/MS modeling situation (deterministic or probabilistic - academic or practitioner), it is clear that a proper and correct treatment of any problem situation is accomplished only when the analysis cuts across this dichotomy.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

The Fifth International Conference on Multiple Criteria Decision Making, not suprisingly, had several objectives. First, it aimed at beinq a forum for exchange and intensive discussion of recent ideas on theory and practice of MCDM, following the now well-established tradition of the previous meetings in the series, organized by H. Thiriez and S. Zionts in Jouy-en-Josas (1975), S. Zionts in Buffalo (1977), G. Fandel and T. Gal in Hagen/Konigswinter (1979) and J. Morse in Newark (1980). Second, closer contacts Nere desired between participants in these meetings and other active groups in the field, prominent among which is the European Working Group on Multiple Criteria Decision Aid. Third, participation of senior or junior researchers who had recently developped important new methodolo0ies, such as the Analytical Hierarchy Process, was actively sought for. Fourth, a synthesis of the rapidly expanding field of MCDM was to be made through selective surveys by leading researchers in the various areas it comprises. Fifth, cross-fertilization and multidisciplinary research was to be encouraged through presentations on the connections between MCDM and mathematics, economics, game theory, computer science and other subjects. Sixth, much emphasis was to be given to real-world applications of MCDM, particularly large scale ones and/or pioneering work in new fields. The present volume reflects the general agreement observed among participants that these goals were largely attained.

The title of this book seems to indicate that the volume is dedicated to a very specialized and narrow area, i. e. , to the relationship between a very special type of optimization and mathematical programming. The contrary is however true. Optimization is certainly a very old and classical area which is of high concern to many disciplines. Engineering as well as management, politics as well as medicine, artificial intelligence as well as operations research, and many other fields are in one way or another concerned with optimization of designs, decisions, structures, procedures, or information processes. It is therefore not surprising that optimization has not grown in a homogeneous way in one discipline either. Traditionally, there was a distinct difference between optimization in engineering, optimization in management, and optimization as it was treated in mathematical sciences. However, for the last decades all these fields have to an increasing degree interacted and contributed to the area of optimization or decision making. In some respects, new disciplines such as artificial intelligence, descriptive decision theory, or modern operations research have facilitated, or even made possible the interaction between the different classical disciplines because they provided bridges and links between areas which had been developing and applied quite independently before. The development of optimiiation over the last decades can best be appreciated when looking at the traditional model of optimization. For a well-structured, Le.

The subject of (static) optimization, also called mathematical programming, is one of the most important and widespread branches of modern mathematics, serving as a cornerstone of such scientific subjects as economic analysis, operations research, management sciences, engineering, chemistry, physics, statistics, computer science, biology, and social sciences. This book presents a unified, progressive treatment of the basic mathematical tools of mathematical programming theory. The authors expose said tools, along with results concerning the most common mathematical programming problems formulated in a finite-dimensional setting, forming the basis for further study of the basic questions on the various algorithmic methods and the most important particular applications of mathematical programming problems. This book assumes no previous experience in optimization theory, and the treatment of the various topics is largely self-contained. Prerequisites are the basic tools of differential calculus for functions of several variables, the basic notions of topology and of linear algebra, and the basic mathematical notions and theoretical background used in analyzing optimization problems. The book is aimed at both undergraduate and postgraduate students interested in mathematical programming problems but also those professionals who use optimization methods and wish to learn the more theoretical aspects of these questions.

Problems with multiple objectives and criteria are generally known as multiple criteria optimization or multiple criteria decision-making (MCDM) problems. So far, these types of problems have typically been modelled and solved by means of linear programming. However, many real-life phenomena are of a nonlinear nature, which is why we need tools for nonlinear programming capable of handling several conflicting or incommensurable objectives. In this case, methods of traditional single objective optimization and linear programming are not enough; we need new ways of thinking, new concepts, and new methods - nonlinear multiobjective optimization. Nonlinear Multiobjective Optimization provides an extensive, up-to-date, self-contained and consistent survey, review of the literature and of the state of the art on nonlinear (deterministic) multiobjective optimization, its methods, its theory and its background. The amount of literature on multiobjective optimization is immense. The treatment in this book is based on approximately 1500 publications in English printed mainly after the year 1980. Problems related to real-life applications often contain irregularities and nonsmoothnesses. The treatment of nondifferentiable multiobjective optimization in the literature is rather rare. For this reason, this book contains material about the possibilities, background, theory and methods of nondifferentiable multiobjective optimization as well. This book is intended for both researchers and students in the areas of (applied) mathematics, engineering, economics, operations research and management science; it is meant for both professionals and practitioners in many different fields of application. The intention has been to provide a consistent summary that may help in selecting an appropriate method for the problem to be solved. It is hoped the extensive bibliography will be of value to researchers.

Introduction to Sensitivity and Stability Analysis in Nonlinear Programming

This book presents a comprehensive optimization-based theory and framework that exploits the synergistic interactions and tradeoffs between process design and operational decisions that span different time scales. Conventional methods in the process industry often isolate decision making mechanisms with a hierarchical information flow to achieve tractable problems, risking suboptimal, even infeasible operations. In this book, foundations of a systematic model-based strategy for simultaneous process design, scheduling, and control optimization is detailed to achieve reduced cost and improved energy consumption in process systems. The material covered in this book is well suited for the use of industrial practitioners, academics, and researchers. In Chapter 1, a historical perspective on the milestones in model-based design optimization techniques is presented along with an overview of the state-of-the-art mathematical tools to solve the resulting complex problems. Chapters 2 and 3 discuss two fundamental concepts that are essential for the reader. These concepts are (i) mixed integer dynamic optimization problems and two algorithms to solve this class of optimization problems, and (ii) developing a model based multiparametric programming model predictive control. These tools are used to systematically evaluate the tradeoffs between different time-scale decisions based on a single high-fidelity model, as demonstrated on (i) design and control, (ii) scheduling and control, and (iii) design, scheduling, and control problems. We present illustrative examples on chemical processing units, including continuous stirred tank reactors, distillation columns, and combined heat and power regeneration units, along with discussions of other relevant work in the literature for each class of problems.