Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more

Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 193 in the Handbook of Clinical Neurology deals with the "How" in the reconfiguration of our approach to slow accelerated brain aging. The book rethinks animal models on which therapies are tested, outlines the progress and expected changes in biological subtyping efforts using lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms of disease pathophysiology, and the growing role of microbiome in shaping disease. The volume separates the potentially disease-modifying neurorescue and neurorestoration, (e.g., gene therapy and cell replacement therapy) from true precision "medicine"–matching biology with the mechanism of intervention of interest. Specific chapters are dedicated to the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures and other evaluations of clinical response, the nuts and bolts of novel adaptive clinical trial designs, and the regulatory changes needed to facilitate drug development for disease-modification purposes. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more

The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.

This issue of PET Clinics focuses on Molecular Imaging and Precision Medicine, Part 1, and is edited by Dr. Rathan Subramaniam. Articles will include: What is Precision Medicine?; Molecular Imaging and Precision Medicine in Head and Neck Cancer; Therapy Response Assessment using Molecular Imaging and Precision Medicine; Molecular Imaging and Precision Medicine in Breast Cancer; Molecular Imaging and Precision Medicine in Dementia and Movement Disorders; Molecular Imaging and Precision Medicine in Prostate Cancer; Molecular Imaging and Precision Medicine in Lymphoma; Radionucleide Therapies in Molecular Imaging and Precision Medicine, PET based Precision Medicine in Thyroid Carcinoma; Molecular Imaging and Precision Medicine in Lung Cancer, and more!

This book explores the fascinating field of precision medicine and its role in understanding and treating genetic diseases in various systems and organs of the human body. Throughout the chapters, topics such as precision medicine in the context of developmental diseases, nutrigenomics and its relationship to diet personalization, pulmonary diseases, musculoskeletal diseases, genetic diseases of the cardiovascular system, and genetic diseases of the hepatic system are explored. In addition, subjects such as the application of genetic tests in precision medicine, analysis of genetic variants, precision medicine in women's health, rare genetic diseases, dermatological diseases, nervous system diseases, renal system diseases and metabolism diseases are addressed. . The book also explores the role of epigenetics in precision medicine, highlighting how modifications to the genetic environment can influence disease development and progression. In addition, topics such as allergic diseases, genetic diseases of the respiratory system and genetic diseases of the musculoskeletal system are discussed. As a comprehensive guide, this book provides valuable insights into precision medicine and its impact on clinical practice in the quest for more accurate diagnoses and personalized treatments. It is essential reading for healthcare professionals, researchers, and students interested in the field of medical genetics and its applications in the era of precision medicine.

A chasm grows between the currently established knowledge and the rapidly evolving landscape of healthcare. As the field of biomedical research hurtles forward with groundbreaking discoveries and transformative technologies, academic scholars find themselves grappling with a significant dilemma. There exists a disconnect between traditional educational resources and the need to keep pace with the latest innovations that are reshaping medicine, diagnosis, and treatment. This widening gap inhibits scholars from adequately preparing their students and hampers their ability to engage in relevant, cutting-edge research, ultimately impeding the advancement of healthcare as a whole. Biomedical Research Developments for Improved Healthcare serves as the ultimate solution to this academic challenge. This book offers a compelling bridge between the realm of academic theory and the dynamic world of practical, real-world biomedical research. Its primary objective is to equip scholars with the knowledge, insights, and materials needed to inspire the next generation of healthcare professionals. By presenting a comprehensive overview of the most recent and groundbreaking advancements in biomedical research, the book enables scholars to transcend the limitations of traditional academia and empower their students with up-to-date, practical knowledge.

This book delves into the delicate realm of neurodegenerative illnesses, navigating the vast landscape of molecular targets with care and purpose. Researchers are studying the complex pathways involved in diseases such as Alzheimer’s, Parkinson’s, and Huntington’s in order to identify specific molecules that could be targeted for therapy. The present work explores potential methods of intervention by carefully analysing neural circuits, protein misfolding, and genetic predispositions, unravelling the complexities of the human mind by focusing on individual molecular targets. As new findings emerge, reducing the severe consequences of neurodegenerative illnesses becomes increasingly possible, providing optimism for millions of people throughout the world.

Personalized medicine (precision medicine) is an evolving field that comprises medical interventions tailored to individuals or groups of patients. It is designed to facilitate enhanced screening and earlier disease detection, more precise disease diagnosis, and improved treatment. Personalized medicine allows patients to receive specific therapies that work best for them aiming for more effective treatment, better outcomes, safer clinical managements and more efficient health systems.

Biosensors in Precision Medicine: From Fundamentals to Future Trends covers important topics regarding biomarkers, including biomarker discovery, validation, application in precision medicine, the principles of biosensors, their use in precision medicine, important analytical parameters, recent advances in bioreceptors and transduction, and more. Finally, the hottest trends of biosensors in precision medicine, including lab-on-a-chip and wearable devices, advances towards telemedicine, machine learning, artificial intelligence and the commerciality of these devices are discussed. Provides a timely review of the state-of-the-art developments in biosensors and their applications in precision medicine Presents an evaluation of case studies, along with real-life examples Addresses recent trends on biosensors for precision medicine