Principles of Evolution considers evolution in the context of systems biology, a contemporary approach for handling biological complexity. Evolution needs this systems perspective for three reasons. First, most activity in living organisms is driven by complex networks of proteins and this has direct implications, particularly for understanding evo-devo and for seeing how variation is initiated. Second, it provides the natural language for discussing phylogenetic trees. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity. Understanding evolution means, on the one hand, describing the history of life and, on the other, making sense of the principles that drove that history. The solution adopted here is to make the science of evolution the primary focus of the book and place the various parts of the history of life in the context of the research that unpicks it. This means that the history is widely distributed across the text. This concise textbook assumes that the reader has a fair amount of biological knowledge and gives equal weight to all the major themes of evolution: the fossil record, phylogenetics, evodevo, and speciation. Principles of Evolution will therefore be an interesting and thought-provoking read for honors-level undergraduates, and graduates working in the biological sciences.

Principles of Evolution covers all aspects of the subject. Following an introductory section that provides necessary background, it has chapters on the evidence for evolution that cover the fossil record, DNA-sequence homologies, and protein homologies (evo-devo). It also includes a full history of life from the first universal common ancestor, through the rise of the eukaryote and on to the major groups of phyla. This section is followed by one on the mechanism of evolution with chapters on variation, selection and speciation. The main part of the book ends with a chapter on human evolution and this is followed by appendices that expand on the making of fossils, the history of the subject and creationism. What marks this book as different from others on evolution is its systems-biology perspective. This new area focuses on the role of protein networks and on multi-level complexity, and is used in three contexts. First, most biological activity is driven by such networks and this has direct implications for understanding evo-devo and for seeing how variation is initiated, mainly during embryogenesis. Second, it provides the natural language for discussing phylogenetics. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity. The book assumes a basic grounding in biology but little mathematics as the difficult subject of evolutionary population genetics is mainly covered qualitatively, with major results being discussed and used rather than derived. Principles of Evolution will be an interesting and thought-provoking text for undergraduates and graduates across the biological sciences.

Cognitive Evolution provides an in-depth exploration of the history and development of cognition, from the beginning of life on Earth to present-day humans. Drawing together evolutionary and comparative research, this book presents a unique perspective on the evolution of human cognition. Adopting an information processing perspective – that is, from inputs to outputs, with all the mental processes in between, Boles provides a systematic overview of the evolutionary development of cognition and of its sensation, movement, and perception components. The book is supported by long-established evolutionary theories and backed up by a wealth of recent research from the growing field of cognitive evolution and cognitive neuroscience to provide a comprehensive text on the subject. Cognitive Evolution is an essential read for advanced undergraduates and postgraduate students of cognitive and evolutionary psychology.

This book attempts to equip the reader with a holistic and accessible account of Islam and evolution. It guides the reader through the different variables that have played a part in the ongoing dialogue between Muslim creationists and evolutionists. This work views the discussion through the lens of al-Ghazālī (1058-1111), a widely-known and well-respected Islamic intellectual from the medieval period. By understanding al-Ghazālī as an Ash’arite theologian, a particular strand of Sunni theology, his metaphysical and hermeneutic ideas are taken to explore if and how much Neo-Darwinian evolution can be accepted. It is shown that his ideas can be used to reach an alignment between Islam and Neo-Darwinian evolution. This book offers a detailed examination that seeks to offer clarity if not agreement in the midst of an intense intellectual conflict and polarity amongst Muslims. As such, it will be of great interest to scholars of Science and Religion, Theology, Philosophy of Religion, Islamic Studies, and Religious Studies more generally. *Winner of the International Society for Science & Religion (ISSR) book prize 2022 (academic category)*

Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. - Provides real-world case studies in drug discovery and the development of drugs - Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development - Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported

Sex and Cohabitation Among Early Humans: Anthropological and Genetic Evidence for Interbreeding Among Early Humans explores the available information regarding interbreeding among different ancestral human species. In addition, it reviews evidence in support of cohabitation as well as cultural and technological interactions and exchanges among early humans, particularly Neanderthal-sapiens interactions. The fields of archaeology, anthropology, genetics, linguistics and molecular evolution have provided a wealth of information on the complex processes involved in human evolution. The book will help readers will develop knowledge on the complexity and multiplicity of hominins, including Homo heidelbergensis, Homo sapiens, and Homo floresiensis. Moreover, the book will help them reach a greater understanding of major topics, such as introgression, migration from Africa, the origin, development and extinction of Neanderthals, interbreeding between Neanderthals and humans, and trait continuity. - Integrates genetic, evolutionary, anthropological, archaeological, anatomical, artistic and linguistic research, among other areas - Written in a simple and direct style that is accessible to readers from different backgrounds and levels of understanding - Provides an integrative and holistic overview of recent developments in research on how different interactions between ancient hominins contributed to the evolution of our species

The third book in Young’s unique trilogy on causality and development continues to locate and define the central role of causality in biopsychosocial and network/systems development, and as a unifying concept of psychology itself. As a way of discussing causality, in general, initially, the book focuses on the acquisition of handedness and hemispheric specialization in infancy and childhood, and their relations to the development of cognition, language, and emotion, in particular. The second part of the book elaborates an innovative 25-step Neo-Eriksonian model of development across the life course based on a Neo-Piagetian model covered in the previous books, completing a step-by-step account of development over the lifespan cognitively and socio-emotionally. It builds on the concept of neo-stage, which is network-based. From this conceptual synthesis, the author’s robust theory of development and causality identifies potential areas for psychological problems and pathology at each developmental step as well as science-based possibilities for their treatment. This elegant volume: Presents a clear picture of the development of handedness and laterality in more depth than has been attempted in the literature to date. Traces the causal concepts of activation-inhibition coordination and networking in the context of development. Describes in depth a novel 25-step Neo-Eriksonian lifespan model of development. Reviews relevant research on Piagetian and Eriksonian theories in development. Emphasizes the clinical utility of the described 25-step Neo-Eriksonian approach to lifespan development. A significant step in understanding this highly nuanced subject and synthesizing a broad knowledge base, Causality and Development will find an interested audience among developmental psychologists, mental health practitioners, academics, and researchers.chers.

This accessible collection debunks pervasive myths about Darwin's life and work, deepening our understanding of the history of science.

Are we alone in the universe? As humans, are we unique or are we part of a greater cosmic existence? What is life’s future on Earth and beyond? How does life begin and develop? These are age-old questions that have inspired wonder and controversy ever since the first people looked up into the sky. With today’s technology, however, we are closer than ever to finding the answers. Astrobiology is the relatively new, but fast growing scientific discipline that involves trying to understand the origin, evolution, and distribution of life within the universe. It is also one of the few scientific disciplines that attracts the public’s intense curiosity and attention. This interest stems largely from the deep personal meaning that the possible existence of extraterrestrial life has for so many. Whether this meaning relates to addressing the “Big Questions” of our existence, the possibility of encountering life on other planets, or the potential impact on our understanding of religion, there is no doubt that the public is firmly vested in finding answers. In this broadly accessible introduction to the field, Bruce Jakosky looks at the search for life in the universe not only from a scientific perspective, but also from a distinctly social one. In lucid and engaging prose, he addresses topics including the contradiction between the public’s fascination and the meager dialogue that exists between those within the scientific community and those outside of it, and what has become some of the most impassioned political wrangling ever seen in government science funding.