As early as in the twenties and thirties of our century Ernst Scharrer published papers suggesting, on the basis of morphological findings, that the brain exhibits secretory function which he called neurosecretion. Only a few decades later Scharrer's presumption was fully confirmed by the isolation of a number of neuropeptides and by the disclosure of their chemical stuctures. Neuropeptide research is one of the most rapidly expanding fields in biomedicin. Initially investigators focused their attention on the existence and role of neuropeptides within the hypothalamo-hypophyseal system. This particular area of research still provides plenty of interesting and fruitful findings. Neuropeptides -including those which were discovered as "hypothalamic" hormones can also be detected in other parts of the brain and even in peripheral organs. In fact, several neuropeptides were found to be synthesized not only by neurones but also by non-neuronal cells. These observations imply much wider functional relevance of neuropeptides than it had been supposed initially. It appears from present day knowledge, that neuropeptides are not only involved in neurotransmission and in the control of pituitary function but also in direct regulation of numerous peripheral biological processes, including reproduction, digestion, immune functions, and even cell growth. This volume includes the invited papers of the Symposium on "Progress in Neuropeptide Research" wh ich was held in Looz/Poland on September 8-10,1988. Topics ofthe symposium reflect upon newly discovered peptides, new localizations, new functions, and new technical approaches.

The explosion of research activity in the field of neuropeptides has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this new and important book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture.

Neuropeptide Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuropeptide Receptors. The editors have built Neuropeptide Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuropeptide Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neuropeptide Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

First multi-year cumulation covers six years: 1965-70.

The explosion of research activity in the field of neuropeptides has led to the idenfication of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The scope of this book includes gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.

This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.

Advances in Invertebrate (Neuro)Endocrinology: A Collection of Reviews in the Post-Genomic Era (2-volume set) provides an informative series of reviews from expert scientists who are at the forefront of their research into the endocrinology of invertebrates. These two volumes are timely and appropriate in this post-genomic era because of the rapid pace of change brought about by genome projects, functional genomics, and genetics (omics technologies). The volume shows the rich history and strong tradition of cutting-edge research using invertebrates that has opened up our broader understanding of comparative endocrinology and the evolution of regulatory pathways and systems. These reviews set the scene and context for this exciting new era of understanding that has come from this post-genomic revolution. This book undertakes the daunting task of covering most of the diverse endocrine systems that exist among invertebrates. The papers in this book will advance our knowledge of invertebrate endocrinology but also of endocrinology in general, making the book will be valuable to researchers and students.