This book outlines the most updated clinical guidelines that are vital for the prevention infections and care of patients with joint infections following a replacement surgery, one of the highest volume medical interventions globally. Sections address the diagnosis, management approaches and prevention of prosthetic joint infections. Written by experts in the field, this text provides a brief overview of the literature and current recommendations in each of the specified areas. Given the rapidly evolving state-of-play in this clinical area, this compendium grows increasingly important to clinicians in their management decisions. Prosthetic Joint Infections is a valuable resource for infectious disease specialists, epidemiologists, surgeons, and orthopedic specialists who may work with patients with prosthetic joint infections.

Periprosthetic joint infection (PJI) is among the most serious complications in the field of endoprosthetics. The number of PJIs is increasing worldwide and poses a real interdisciplinary challenge for everyone involved. For the patient concerned, it is necessary to promptly work out an adequate therapy solution to fight off the infection. Both the clinical experience of the surgeon and the proper diagnostic processes are prerequisite for the reliable detection and identification of an infection. The microbiologist is responsible for identifying the causative germs by screening the patient’s synovial fluid and tissue samples. Based on the findings and subsequent resistance testing, the infectious disease specialist can recommend the appropriate antibiotic therapy. Furthermore, the clinical pharmacist is consulted regularly throughout the therapy to discuss the risk of potential drug interactions. The surgeon will proceed with the revision surgery, following defined algorithms. Adequate radical debridement of infected and necrotic surrounding tissue is the most important step towards a successful cure of the infection. Accompanying the surgery, anti-infective agents are given systemically and locally. While systemic application of anti-infectives mainly reduces the number of haematogenic-spreading planktonic germs, local application immediately forms a colonization barrier and protects the implant from sessile biofilm formation. Concurrently, antibiotics are actively released from the implant, resulting in local germ reduction. Thus, local agents are embedded in the concept of surgical PJI treatment as a reliable adjuvant measure and they sustainably support the successful outcome. In one-stage procedures, local agents are released from specialized antibiotic-loaded bone cements, while in two- or multi-stage procedures, local agents are released from corresponding temporary spacers (interim prostheses). Even from an economic standpoint, the combination of systemic and local agent application is meaningful. Furthermore, there are some interesting trends towards the coating of metallic implants to protect against biofilm formation on the implant surface. On the basis of their personal experience, specialists from all over the world present, explain and discuss preventive approaches, appropriate diagnostic strategies for detection, reproducible effective surgical treatments as well as the economic impact of PJI. The reader can use this book as a solid platform for comparing their own approach to PJI treatment with the specialists’ recommendations.

This book provides a state-of-the-art, worldwide overview of treatment options available for periprosthetic joint infection (PJI). It highlights areas where tremendous progress has been made over the past few years, looking at current evidence, projecting a way forward, and discussing key topics where ongoing research is needed and could potentially have a huge impact on the field. In addition to familiarising readers with effective diagnostics and treatment strategies, factors such as socioeconomics and associated morbidity are also examined in relation to this increasingly common condition. Periprosthetic Joint Infections: Changing Paradigms includes expert guidance based on the best available evidence and practice that can be applied in even the most difficult infection cases. To create this keystone resource for the orthopaedic community, the editors have brought together prominent experts from Europe and the US to give an international, authoritative perspective on this important topic. This book is an essential guide for specialists who deal with challenging cases of PJI in clinical practice or researchers who are seeking a reference point to undertake further studies in this growing area.

This book Periprosthetic Joint Infection is a portable guide to the practical management of surgical site infections following orthopedic procedures. It designed to help answer clinician's questions regarding the prevention and treatment of periprosthetic infections. It organized for rapid review, featuring evidence reviews, pitfalls, Rothman Institute Current Practices and Controversies. The guide is being included in the course materials for the 29th Annual Current Concepts in Joint Replacement® (CCJR) meeting thanks to a generous educational grant from 3M Health Care.

Management of Periprosthetic Joint Infections (PJIs): Management of PJIs discusses periprosthetic joint infection (PJI), a fairly rare occurrence that is nonetheless one of the most serious complications in joint replacement surgery. Intricate interactions between the pathogen, the host, and the implant can result in PJIs which are not only physically devastating for the patient, but also financially crippling for health authorities and insurance companies. Actions taken to minimize the risk of PJIs can be extremely challenging for the orthopaedic community. Consequently, new research, which is detailed in this comprehensive book, is being undertaken to minimize and manage these challenging infections. - Provides essential background knowledge on the mechanisms and identification of PJIs - Dedicated chapters focus on the complex, but vital eccentricities between PJIs in different areas of the body - Contains contributions from a mixture of clinical and academic experts in the field, thus ensuring balanced coverage

Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

BONE AND JOINT INFECTIONS Explore this comprehensive presentation of bone and joint infections, including non-implant and implant-associated orthopedic infections In the newly revised Second Edition of Bone and Joint Infections: From Microbiology to Diagnostics and Treatment, accomplished researcher and author Werner Zimmerli delivers a comprehensive overview of the most recent developments in the subject of bone and joint infection. Covering much of the new information appearing over the last five years, the book includes four new chapters presenting the diagnostic approach in bone and joint infections, discussing the identification of pathogens by non-culture techniques, management of multi-resistant bacteria in bone and joint infections by bacteriophages, and unusual microorganisms in periprosthetic joint infections. Many of the chapters are also updated to include new information on topics like eubacterial PCR, multiplex PCR, and the shotgun metagenomics approach. These subjects are of increased applicability and interest to increase the fraction of cases with identified pathogens. The book also helps clinicians to understand MRI-based images and rapidly interpret and plan for comprehensive therapy. Readers will also benefit from the inclusion of: A thorough introduction to the pharmacokinetics and pharmacodynamics of antibiotics in bone and preclinical models of infection in bone and joint surgery An exploration of native joint arthritis in children and adults, as well as an overview of septic arthritis of axial joints A practical discussion of the general aspects of periprosthetic joint infection, as well as specific aspects of periprosthetic joint infection after total hip and knee, shoulder, elbow, and ankle arthroplasty A concise treatment of osteomyelitis in children and adults Perfect for infectious disease specialists, microbiologists, orthopedic and trauma surgeons, and internists, Bone and Joint Infections: From Microbiology to Diagnostics and Treatment will also earn a place in the libraries of professionals working in the implant industry and pharmaceuticals, as well as clinical pharmacologists and rheumatologists.

Written by an international group of renowned shoulder surgeons, this book is the most comprehensive, current reference devoted to revision and complex shoulder arthroplasty. The first section thoroughly explains the circumstances under which implants can fail and the details involved in assessing the problems in failed shoulder arthroplasty. The second section describes techniques for revision shoulder arthroplasty, including techniques for both anatomic reconstruction and reverse arthroplasty and the role of arthroscopy in revision surgery. The third section focuses on specific issues for various specialized types of shoulder reconstruction requiring prosthetic arthroplasty. More than 400 illustrations complement the text.

Dr. Schmitt has put together a comprehensive issue devoted to bone and joint infections. Top experts have created state-of-the-art clinical reviews devoted to the following topics: Native septic arthritis; Reactive arthritis; Prevention of infection in orthopedic prosthetic surgery; Infections of the spine; Radiologic approach to musculoskeletal infections; Infections associated with open fractures; Fungal musculoskeletal infections; Mycobacterial musculoskeletal infections; Diagnosis of prosthetic joint infections-cultures, biomarkers, and criteria; Management of Prosthetic Joint Infections; Osteomyelitis In adults; and Osteomyelitis in children. Readers will come away with clinical information that can be immediately applied to caring for patients recovering from orthopedic surgeries.