We are in the midst of what is being called the 'psychedelic renaissance' with growing interest into how psychedelics alter consciousness, brain function and brain connectivity. The acute, often profound, effects of the psychedelic experience can induce lasting improvements in mental health demonstrating that chemistry forms the basis of mystical experience, consciousness and mental wellbeing. - This volume is a collection of chapters by world leaders in fields of neurobiology, neuropsychiatry, psychology, ethnography and pharmacology, addressing the neurobiological mechanisms of action of various classic and atypical psychedelics, their therapeutic potential as well as the possible risks associated with their use

• Examines the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, and MDMA • Explains the physiological mechanisms behind visionary effects, including what is happening in the brain and how each psychedelic is processed by the body • Shares safe strategies for using psychedelics, including harm-reduction techniques, and looks at where the future of psychedelic therapies is likely to go With the widespread legalization of marijuana and the increasing use of psychoactives in controlled therapy settings, further research and understanding of psychedelics is now possible. Yet while individual accounts of their use abound, exactly what’s happening to the brain and body when using these substances is still not widely understood. Longtime pharmacological researcher Genís Ona presents a comprehensive look at the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, tropane alkaloids, and MDMA. Exploring how psychedelics work within the brain, Ona shares results from his extensive research to reveal the physiological mechanisms that allow these molecules to have their visionary effects, explaining what is happening at the receptor level as well as the “cascade” effects that differ from substance to substance. He examines how the body processes each substance, describing how each psychedelic is released, absorbed, distributed, metabolized, and eliminated. He also details possible dangerous interactions between these substances and other drugs as well as their potential toxicity. Although his main focus is the biological and neurological effects of psychedelics, Ona also explores the mystical and spiritual dimension of psychedelic use, particularly as practiced in Indigenous traditions, showing how they enable access to a profound spiritual territory. He shares safe strategies for using psychedelics and looks at where the future of psychedelic therapies is likely to go, with an emphasis on ensuring that traditional knowledge is respected, honored, and protected.

This volume brings together the latest basic and clinical research examining the effects and underlying mechanisms of psychedelic drugs. Examples of drugs within this group include LSD, psilocybin, and mescaline. Despite their structural differences, these compounds produce remarkably similar experiences in humans and share a common mechanism of action. Commonalities among the substances in this family are addressed both at the clinical and phenomenological level and at the basic neurobiological mechanism level. To the extent possible, contributions relate the clinical and preclinical findings to one another across species. The volume addresses both the risks associated with the use of these drugs and the potential medical benefits that might be associated with these and related compounds.

This book is the first scholarly monograph in English devoted to the philosophical analysis of psychedelic drugs. Its central focus is the apparent conflict between the growing use of psychedelics in psychiatry and the philosophical worldview of naturalism.

Psychedelics are part of a resurgence of interest in consciousness studies, especially as altered states of consciousness are being re-examined in the context of psychedelic-assisted therapies. To date, discussions about psychedelics in modern medicine have been dominated by studies in biomedicine. However, given that cultural factors play a significant role in the subjective effects of psychedelics, psychedelics can be considered a uniquely powerful point of convergence between the cultural and biomedical. Writers and artists, alongside psychiatrists and pharmacologists, have participated in shaping ‘the psychedelic experience’ by drawing on a rich set of approaches that blend narrative, arts, and humanities concepts to explain and interpret psychedelic experiences and explore consciousness for creative purposes. Psychedelic studies, past and present, emphasize the importance of ‘set and setting’ or the context of psychedelic consumption and its paramount importance in shaping psychedelic experiences. These non-pharmacological factors rely on a different set of methods and interpretations that necessarily rely on studies conducted outside of the biomedical sciences.

This book revaluates Carl Jung’s ideas in the context of contemporary research in the evolutionary sciences. Recent work in developmental biology, as well as experimental and psychedelic neuroscience, have provided empirical evidence that supports some of Jung’s central claims about the nature and evolution of consciousness. Beginning with a historical contextualisation of the genesis of Jung’s evolutionary thought and its roots in the work of the 19th century Naturphilosophen, the book then outlines a model of analytical psychology grounded in modern theories of brain development and life history theory. The book also explores research on evolved sex based differences and their relevance to Jung’s concept of the anima and animus. Seeking to build bridges between analytical psychology and contemporary evolutionary studies and associated fields, this book will appeal to scholars of analytical and depth psychology, as well as researchers in the evolutionary and brain sciences.

‘An original and thrilling investigation into psychedelics and the claims that currently surround them, achieving profound insights’ Mike Jay, author of Psychonauts Psychedelics have made a comeback, but the truth is they remain a mystery. In this daring, profound and wildly entertaining investigation, clinical neuropsychologist Andy Mitchell tests the claims being made for these substances by taking ten different psychedelics in ten different settings. Journeying from a neuroimaging lab in London to the Colombian Amazon via Silicon Valley and his friend’s basement kitchen, his encounters with scientists and gangsters, venture capitalists and con men, psychonauts and shamans, and above all with the drugs themselves, take us beyond the hype and reveal the reality of psychedelics in all their strangeness, darkness and wonder. ‘Canny and somewhat sceptical . . . rigorous and penetrating . . . This is a wonderful book, a journey into the nature and potential of consciousness itself’ Literary Review 'An incisive, deeply personal and beautifully written account of the power, the uses and the modern misuses of psychedelics. Highly recommended' Anil Seth, author of Being You ‘Utterly compelling. Some books are in a category of their own and this is one them. Reading it is like having an out of body experience’ Mark Miodownik, author of Stuff Matters ‘Superb . . . brilliant’ TLS

Winner of the 2022 NAAP Gradiva Award for Best Edited Book In this volume, internationally acclaimed psychoanalysts, philosophers, and scholars of humanities examine the mind-body problem and provide differing analyses on the nature of mind, unconscious structure, mental properties, qualia, and the contours of consciousness. Given that disciplines from the humanities and the social sciences to neuroscience cannot agree upon the nature of consciousness—from what constitutes psychic reality to mental properties, psychoanalysis has a unique perspective that is largely ignored by mainstream paradigms. This book provides a comprehensive exploration of the mind-body problem in various psychoanalytic schools of thought, including philosophical and metapsychological points of view. Psychoanalysis and the Mind-Body Problem will be of interest to psychoanalysts, philosophers, neuroscientists, evolutionary biologists, academics, and those generally interested in the humanities, cognitive science, and the philosophy of mind.

This handbook reviews promising applications of psychedelics in treatment of such challenging psychiatric problems as posttraumatic stress disorder, major depression, substance use disorders, and end-of-life anxiety. Experts from multiple disciplines synthesize current knowledge on psilocybin, MDMA, ketamine, and other medical hallucinogens. The volume comprehensively examines these substances' neurobiological mechanisms, clinical effects, therapeutic potential, risks, and anthropological and historical contexts. Coverage ranges from basic science to practical clinical considerations, including patient screening and selection, dosages and routes of administration, how psychedelic-assisted sessions are structured and conducted, and management of adverse reactions.