This issue provides fully updated information on respiratory infections, including healthcare associated pneumonia, new diagnostic tests for pneumonia, epidemic viral pneumonia and other emerging pathogens, biomarkers to optimize antibiotic therapy for pneumonia, pharmacokinetics and pharmacodynamics to improve management of penumonia. Nosocomial tracheobronchitis and bronchiectasis are also discussed. Articles on CAP and VAP, including an examination of the impact of guidelines on outcomes, de-escalation therapy, inhaled antibiotic therapy and prevention of VAP are also included.

This issue of Sleep Medicine Clinics, guest-edited by Drs. Amen Sergew and Lisa F. Wolfe, focuses on Noninvasive Ventilation and Sleep Medicine. This issue is one of four selected each year by series Consulting Editor, Dr. Teofilo Lee-Chiong. Articles include: Obesity hypoventilation - Traditional vs Non Traditional Populations; Spinal cord injury; Peri-Operative Care and Medication Related Hypoventilation; Lifetime Care of Duchenne Muscular Dystrophy; Management of Chronic Respiratory Failure in COPD - High and Low Intensity Ventilation; Management of Rare Causes Pediatric Chronic Respiratory Failure; Noninvasive Ventilator Management of ALS - Bulbar vs non Bulbar; Parsonage Turner; Noninvasive Ventilator Devices and Modes; Tailoring the Sleep Lab for Chronic Respiratory Failure; Long-Term Follow Up of Noninvasive Ventilation: Downloads and Troubleshooting; Extubating to Noninvasive Ventilation – NIV from ICU to Home; and From Tracheostomy to Noninvasive Ventilation – NIV from Long Term Acute Care to Home.

In this issue of Infectious Disease Clinics, guest editors Rachael Lee and Helen W. Boucher bring their considerable expertise to the topic of Lung Infections. Top experts in the field provide important updates on hot topics such as Viral Pneumonias, Infectious Pulmonary Diseases, Infections in Heart and Lung Transplant Recipients, and more. Contains 12 practice-oriented topics including Opportunistic Infections Post-Lung Transplantation: Viral, Fungal, and Mycobacterial; Novel Approaches to Multidrug-Resistant Infections in Cystic Fibrosis; Coronavirus Disease-2019 in the Immunocompromised Host; Novel and Rapid Diagnostics for Common Infections in the Critically Ill Patient; and more. Provides in-depth clinical reviews on lung infections, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Sleep Medicine Clinics, guest editor Dr. Krishna M. Sundar brings his considerable expertise to the topic of Overlap of Respiratory Problems with Sleep Disordered Breathing. Given the rising prevalence of obesity and increasing demand for chronic respiratory support in pulmonary and chest wall disorders, this issue offers articles from top experts on seamlessly integrating the management of sleep-disordered breathing with novel ventilatory strategies employed for chronic respiratory failure. Contains 15 relevant, practice-oriented topics including mechanical interactions between upper airway and lower airways that affect propensity to sleep-disordered breathing; effects of sleep apnea on airway immunity and susceptibility to infection; epigenetic alterations, oxidative stress and telomere shortening from OSA: implications for chronic lung disease; obstructive sleep apnea and chronic cough; and more. Provides in-depth clinical reviews on overlap of respiratory problems with sleep disordered breathing, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Clinics in Chest Medicine, guest-edited by Dr. Margaret Pisani, is focused on Gender and Respiratory Disease. Topics discussed in this issue include but are not limited to: What are sex and gender and how can we study their impact in respiratory disease?, Sex differences in respiratory physiology, Impact of gender on social determinants of health, Gender differences in obstructive sleep apnea, Impact of gender on sleep disorders across the lifespan, Differences between men and women with COPD, Women and Lung Cancer, Pulmonary considerations in pregnant women and Asthma in women-gender specific considerations.

This issue of Clinics in Chest Medicine is Guest Edited by Kristina Crothers, MD from the University of Washington and will focus on HIV and Respiratory Disease. Article topics include Abnormalities in Host Defense, Antiretroviral Therapy and Lung Immunology, HIV associated Pneumonia, HIV associated Tuberculosis, HIV associated lung malignancies, and HIV associated COPD.

In this issue of Clinics in Chest Medicine, guest editors Drs. Clemente J. Britto and Jennifer L. Taylor-Cousar bring their considerable expertise to Advances in Cystic Fibrosis. Top experts in the field cover key topics such as genetics of cystic fibrosis (CF): clinical implications; innate and adaptive immunity in CF; novel applications of biomarkers and personalized medicine to define the spectrum of CF; emerging approaches to understand CF pathogenesis; and more. - Contains 18 relevant, practice-oriented topics including novel approaches to multidrug resistant infections in CF; clinical outcomes of highly-effective modulator therapy; nontuberculous mycobacterial infections in CF; management of mental health in CF; sexual and reproductive health in CF; nutritional management in CF; transitions of care in CF; and more. - Provides in-depth clinical reviews on advances in cystic fibrosis, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The first issue of Clinics in Chest Medicine to be published with this focus, this issue reviews bronchiectasis from numerous angles to provide comprehensive coverage on this important subject. Epidemiology, airway defense mechanisms, pathogenesis, imaging and genetic causes of bronchiectasis are discussed. Allergic bronchopulmonary aspergillosis is addressed, as well as non-tuberculous mycobacteria as a cause of bronchiectasis. Authors examine how to evaluate the success of therapy for bronchiectasis (what endpoints to use) and then discuss a variety of therapy options: inhaled and systemic antibiotic treatment, chest physiotherapy, pharmacologic agents for mucous clearance, antipinflammatory therapy and macrolides. Pulmonary resection and lung transplantation for bronchiectasis are reviewed. Recent advances in Cystic Fibrosis are also discussed.

Pleural Disease, An Issue of Clinics in Chest Medicine, E-Book

This issue of Clinics in Chest Medicine, edited by Dr. Danielle Antin-Ozerkis and Dr. Kristin Highland, is devoted to Thoracic Manifestations of Rheumatic Disease. Topics include: Scleroderma/Mixed Connective Tissue Disease (MCTD); Lupus and APLAS; Sjögren's Syndrome; Rheumatoid Arthritis; Polymyositis/Dermatomyositis; Small Vessel Vasculidities: GPA/MPA/EGPA; Ig4 Related Disease; Spondylarthropathies; Interstitial Pneumonia with Autoimmune Features; Immunosuppressive Therapy (toxicity monitoring, PJP prophylaxis, bone health, immunization, pulmonary drug toxicity); Transplantation (scleroderma, challenges with PRAs, reflux/dysmotility); Biomarkers, Antibodies, and Immunologic Evaluation of the Patient with Lung Disease; Radiology/Imaging of Pulmonary Manifestation of Connective Tissue Disease; and Pulmonary Pathology in Connective Tissue Disease.