This atlas explores the latest advances in radionuclide imaging in the field of inflammatory diseases and infections, which now typically includes multimodality fusion imaging (e.g. in SPECT/CT and in PET/CT). In addition to describing the pathophysiologic and molecular mechanisms on which the radionuclide imaging of infection/inflammation is based, the clinical relevance and impact of such procedures are demonstrated in a collection of richly illustrated teaching cases, which describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Special emphasis is placed on using tomographic multimodality imaging to increase both the sensitivity and specificity of radionuclide imaging. The aim of the second edition of this book is to update the first (published in 2013) by reflecting the changes in this rapidly evolving field. Particular attention is paid to the latest advances in the radionuclide imaging of infection and inflammation, including the expanding role of hybrid imaging with [18F]FDG PET/CT SPECT/CT, without neglecting new radiotracers proposed for the imaging of infection/inflammation. Written by respected experts in the field, the book will be an invaluable tool for residents in nuclear medicine, as well as for other specialists.

Thoroughly and systematically presents the state-of-the-art in the diagnostic uses of radiologic imaging and nuclear medicine in the diagnosis and management of infectious and inflammatory diseases Although our understanding of microorganisms has advanced significantly and antimicrobial therapy has become increasingly available, infection remains a major cause of patient morbidity and mortality. Imaging of infection and inflammation provides a classic example of radiology and nuclear medicine’s strengths as well as weaknesses in the discovery and diagnosis of disease. Fortunately, the weaknesses are subsiding as new studies and techniques point to better planning and precision in the use of single and combined imaging modalities. Diagnostic Imaging of Infections and Inflammatory Diseases: A Multidisciplinary Approach deals with the very latest developments in the use of radiologic techniques and modalities in the management of patients with a host of infectious and inflammatory diseases. Tremendously timely and useful, this innovative, multidisciplinary book covers a wide range of topics in three parts: PART 1: Infections and Host Response Epidemiology of Infections in the New Century Bacterial Osteomyelitis: the Clinician Point of View PART 2: Radiological Imaging Radiological Imaging of Osteomyelitis Radiological Imaging of Spine Infection Radiological Imaging of Soft Tissue Infections Radiological Imaging of Abdominal Infections and Inflammatory Disease Radiological Imaging of Vascular Graft Infection Radiological Imaging of TB and HIV PART 3: Nuclear Medicine Imaging Nuclear Medicine Imaging of Infections: Techniques, Acquisition Protocols, and Interpretation Criteria Nuclear Medicine Imaging of Osteomyelitis: WBC, Monoclonal Antibody, or Bacterial Imaging? Nuclear Medicine Imaging of Spondylodiscitis: The Emerging Role of PET Nuclear Medicine Imaging of Soft Tissue Infections Nuclear Medicine Imaging of Infections and Inflammatory Diseases of the Abdomen Nuclear Medicine Imaging of Vascular Graft Infections: The Added Role of Hybrid Imaging Nuclear Medicine Imaging of TB and HIV Nuclear Medicine Imaging of Fever of Unknown Origin Nuclear Medicine Imaging of Inflammatory Diseases Along with carefully developed clinical cases describing the management of patients with inflammation and infection, Diagnostic Imaging of Infections and Inflammatory Diseases is an ideal guide for radiologists and nuclear medicine physicians as well as clinical specialists from many other fields.

PET/CT holds great promise for the management of many types of infection and inflammation. This issue discusses many of these uses, starting with arthroplasty-associated infection. FDG PET/CT also has utility in inflammatory bowel disease. This issue also discusses the utilization of FDG PET and PET/CT in the evaluation of diabetic foot, and in monitoring therapeutic effect in patients without malignancy. PET/CT is reviewed regarding its use in patients with sarcoidosis or IgG4 disease. Also covered is the application of FDG PET/CT in detecting the source of fever of unknown origin. Artherosclerosis and vasculitis can be assessed by PET/CT and FDG PET/CT can also be used in the management of severe infection in patients with malignancies. Finally, the issue discusses the use of PET and PET/CT in the evaluation of osteomyelitis.

This work has true international scope, being a unique European/American joint venture that focuses on the state of the art in both diagnostic and therapeutic radionuclide methodology. Pertinent clinical applications are emphasized rather than attempting to cover everything included in the several large comprehensive texts available in our field. This "practical" approach should make it an essential guide to nuclear medicine physicians, technologists, students and interested clinicians alike.

Building on the traditional concept of nuclear medicine, this textbook presents cutting-edge concepts of hybrid imaging and discusses the close interactions between nuclear medicine and other clinical specialties, in order to achieve the best possible outcomes for patients. Today the diagnostic applications of nuclear medicine are no longer stand-alone procedures, separate from other diagnostic imaging modalities. This is especially true for hybrid imaging guided interventional radiology or surgical procedures. Accordingly, today’s nuclear medicine specialists are actually specialists in multimodality imaging (in addition to their expertise in the diagnostic and therapeutic uses of radionuclides). This new role requires a new core curriculum for training nuclear medicine specialists. This textbook is designed to meet these new educational needs, and to prepare nuclear physicians and technologists for careers in this exciting specialty.

This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT). Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future. The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other. Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.

This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.

This book offers a systematic coverage of diagnostic imaging in infectious and inflammatory diseases in musculoskeletal system. The first part is devoted to a general review of infectious diseases in musculoskeletal system, as well as pathogenic classification, imaging techniques, pathogenic and imaging characteristics. In the following parts, imaging interpretation of typical infectious and inflammatory diseases affecting bone, joint, and soft tissue is described. Each disease is clearly illustrated using cases combined with high-resolution CT, MRI and PET. The book provides a valuable reference source for radiologists and doctors working in the area of infectious and inflammatory diseases.

This latest edition is a comprehensive review of radiology that can be used as a first reader by beginning residents, referred to during rotations, and used to study for the American Board of Radiology exams. It covers all ten subspecialties of radiology and includes more than 2,700 illustrations.

This pioneering book, now in its fourth edition, presents the cutting-edge developments in pediatric nuclear medicine. Thoroughly revised and updated, it retains the fundamentals that anchor the book’s distinguished reputation and includes the latest advances in PET/CT, SPECT, hybrid imaging, and molecular imaging. Pediatric Nuclear Medicine and Molecular Imaging, Fourth Edition, is an excellent resource for nuclear medicine physicians, diagnostic radiologists, pediatricians, and residents and fellows. The Fourth Edition features: · 16 new chapters, including PET and PET/CT in Children and Young Adults; Lymphoscintigraphy; Skeletal Scintigraphy; Neuroblastoma; Lymphomas and Lymphoproliferative Disorders; Functional Imaging of Pediatric Musculoskeletal Tumors; Solid Tumors in Childhood; Pediatric Molecular Imaging; Combined PET/MRI in Childhood; Radiation Exposures; Radiation Protection in Pediatric Nuclear Medicine; and Dose Optimization in Pediatric Nuclear Medicine. · Discussion of the use of image fusion and hybrid imaging in children. · Strategies for communicating potential radiation risk to patients, families and members of the healthcare team. · Methods to optimize pediatric radiopharmaceutical administered doses and improve image quality. S. Ted Treves, MD, is Professor of Radiology at Harvard Medical School, Founder and Former Chief, Division of Nuclear Medicine and Molecular Imaging, Ch ildren’s Hospital Boston (1970-2011). In 2013, he received the Society of Nuclear Medicine and Molecular Imaging’s Georg Charles de Hevesy Nuclear Pioneer Award for outstanding contributions to the field of Nuclear Medicine.