Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine sheds new light on various applications of microbial metabolites in the biomedical sector. The purpose of this book is to integrate the latest research advancements on the application of microbial metabolites in the medical industry into a single platform. In 10 chapters, the significance of biomedical applications and future therapeutic applications of microbial metabolites in human health are highlighted. Several chapters are dedicated to the role of microbial metabolites in precision medicine like the impact of the activities of microbial metabolites in antitumor and antidiabetic agents and immunosuppressive activities. It also provides a roadmap for drugs discovery based on antimicrobial products and the effect of microbial metabolites on humans' health and the immune system. The book finalizes with a chapter on the use of microbial metabolites in OMICS technology. Recent Advances and Future Perspectives of Microbial Metabolites: Applications in Biomedicine targets researchers from both academia and industry, professors, and graduate students from microbiology, molecular biology, biotechnology, and immunology. - Highlights various microbial metabolites and their application in the biomedical sector - Illustrates the application of microbial metabolites as potential therapeutic agents - Convenient for buyers and readers to understand the basics with advanced information of microbial metabolites

Bioactive Microbial Metabolites: Scope and Challenges not only focuses on the identification, separation and purification of bioactive metabolites, the book also provides an understanding of the metabolic pathways for bioactive metabolites production that play an important role in modern healthcare as frontline treatments for many diseases. This is a valuable reference for research students, academicians and scientists in environmental microbiology and biotechnology, and for industry personnel related to microbiology/ biotechnology. The science discussed herein plays an important role in expanding the market of antibiotics, food and agriculture but also offers eco-friendly, safer and profitable solutions to respective industries. - Focuses on the identification and structure elucidation of novel microbial metabolites - Uncovers extended functions of microbial metabolites - Provides understanding of metabolic pathways for bioactive metabolites production by using several illustrations, figures and tables so that the readers can easily grasp key concepts

This book provides a comprehensive overview of cutting-edge biotechnological approaches for enhancing plant secondary metabolites to address abiotic stress, offering valuable insights into the future of utilizing plants for medicinal and industrial purposes. Various books on plant secondary metabolites are available, however, no book has an overview of the recent trends and future prospects of all the methods available to enhance the contents of the plant secondary metabolites. Plant Secondary Metabolites and Abiotic Stress aims to give an overview of all the available strategies to ameliorate abiotic stress in plants by modulating secondary metabolites using biotechnological approaches including plant tissue cultures, synthetic metabolic pathway engineering, targeted gene silencing, and editing using RNAi and CRISPR CAS9 technologies.

A human being consists of a mammalian component and a multiplicity of microbes, collectively referred to as the "microbiota" or "microbiome," with which it has a symbiotic relationship. The microbiota is comprised of a variety of communities, the composition of each being dependent on the body site it inhabits. This community variation arises because the numerous locations on a human being provide very different environments, each of which favors the establishment of a distinct microbial community. Each community consists of bacteria, fungi and viruses with, in some cases, archaea and/or protozoa. It is increasingly being recognized that the indigenous microbiota plays an important role in maintaining the health of its human host. However, changes in the overall composition of a microbial community at a body site, or an increase in the proportion of a particular species in that community, can result in disease or other adverse consequences for the host. The Human Microbiota in Health and Disease: An Ecological and Community-Based Approach describes the nature of the various communities inhabiting humans as well as the important roles they play in human health and disease. It discusses techniques used to determine microbial community composition and features a chapter devoted to the many factors that underlie this mammalian–microbe symbiosis. Uniquely, the book adopts an ecological approach to examining the microbial community’s composition at a particular body site and why certain factors can shift a community from a eubiotic to a dysbiotic state. The book is for undergraduates and postgraduates on courses with a module on the indigenous microbiota of humans. It will also be useful to scientists, clinicians, and others seeking information on the human microbiota and its role in health and disease.

Research on microbes plays an essential role in the improvement of biotechnological and biomedical areas. It has turned into a subject of expanding significance as new organisms and their related biomolecules are being characterized for several applications in health and agriculture. Microbial biomolecules confer the ability of microbes to cope with a range of adverse conditions. However, these biomolecules have several advantages over the plant origin, which makes them a suitable target in drug discovery and development. The reasons could be that microbial sources can be genetically engineered to enhance the production of desired natural production by large-scale fermentation. The interaction between microbes and their biotic and abiotic environment is fundamental to numerous processes taking place in the biosphere. The natural environments and hosts of these microorganisms are extremely diverse being reflected by the fact that microbes are widespread and occur in nearly every biological community on Earth. This metabolic versatility makes microbes interesting objects for a range of economically important biotechnological applications. Most of the biotechniques are established but inefficient genetic engineering strategies are still a bottleneck for selected microbe producing industrial scale biomolecules. Therefore, untapped microbial biodiversity and related metablomics, give a noteworthy wellspring of biologicals for the advancement of meds, immunizations, enhanced plants and for other natural applications. The present eBook volume contains articles on microbial secondary metabolites, microbial biosynthetic potential including biosynthetic gene expression, and metagenomics obtained from microorganism isolated unique from habitats like marine sources, endophytes, thermal springs, deserts, etc.

This book reviews the latest advances in the bioelectrochemical degradation of recalcitrant environmental contaminants. The first part introduces readers to the basic principles and methodologies of bioelectrochemical systems, electron-respiring microorganisms, the electron transfer mechanism and functional electrode materials. In turn, the second part addresses the bioelectrochemical remediation/treatment of various environmental pollutants (including highly toxic refractory organics, heavy metals, and nitrates) in wastewater, sediment and wetlands. Reactor configuration optimization, hybrid technology amplification and enhanced removal principles and techniques are also discussed. The book offers a valuable resource for all researchers and professionals working in environmental science and engineering, bioelectrochemistry, environmental microbiology and biotechnology.

Ruminants are hoofed mammals with a unique digestive system that allows them to better create energy from fibrous plant material than other herbivores. Small ruminants (such as sheep and goats) play an important role in global food security and nutrition, as well as in the livelihoods of farmers and others along the food chain. Due to the unique digestive systems of ruminants, many major studies have focused on the effects of high-concentrate diets on rumen fermentation, ruminal acidosis, and their microbial properties and functions. Therefore, paying attention to the intestinal health of small ruminants during the rapid fattening stage has important implications for their health and productivity. Ruminants host a taxonomically diverse microbiota in their rumen, which is generally considered to be the most efficient natural fermentation system. Rumen microorganisms facilitate the degradation of otherwise indigestible plant fibres into absorbable compounds such as proteins and volatile fatty acids, the main source of energy and nutrition for ruminants. They are composed of a complex and dynamic assembly of bacteria, fungi, archaea, protozoa, and viruses. Diets and additives directly affect the number and viability of rumen microorganisms.

Microorganisms are a good indicator of soil health. Plant growth-promoting microorganisms protect plants from the stresses of water, salt, metal, biotic, and so on, and are well known for strategically modulating the plant mechanisms to defend and mitigate environmental stresses. Taking a multidisciplinary approach, this volume explores the role of plant microorganisms in ecological and agricultural revitalization beyond normal agriculture practices and offers practical and applied solutions for the restoration of degraded lands to fulfill human needs with food, fodder, fuel, and fiber. It also provides a single comprehensive platform for soil scientists, agriculture specialists, ecologists, and those in related disciplines. Features • Presents cutting-edge microbial biotechnology as a tool for restoring degraded lands • Explores the aspects of sustainable development of degraded lands using microorganism-inspired land remediation • Highlights sustainable food production intensification in nutrient-poor lands through innovative use of microbial inoculants • Explains the remediation of polluted land for regaining biodiversity and achieving United Nations Sustainable Development Goals • Includes many real-life applications from South Asia offering solutions to today’s agricultural problems This book will be of interest to professionals, researchers, and students in environmental, soil, and agricultural sciences as well as stakeholders, policy makers, and practitioners with an interest in this field.

Microbial electrosynthesis (MES) is an emerging technology that enables the synthesis of value-added chemicals from carbon dioxide (CO2) or inorganic carbon compounds by coupling renewable electricity to microbial metabolism. However, MES still faces challenges in achieving high production of value-added chemicals due to the limited extracellular electron transfer efficiency at the biotic-abiotic interfaces. To overcome this bottleneck, it is crucial to develop novel cathodes and modified materials. This review systematically summarizes recent advancements in cathode materials in the field of electrocatalyst-assisted and photocatalyst-assisted MES. The effects of various material types are further investigated by comparing metal-free and metal materials and photocatalyst materials of different semiconductor types. Additionally, the review introduces the maximum production rate of value-added chemicals and conversion efficiency achieved by these cathode materials while highlighting the advantages and disadvantages of different material types. To the best of our knowledge, in electrocatalyst-assisted systems, the maximum CH4 yield on graphene aerogel/polypyrrole cathode achieved 1,672 mmol m-2 d-1, and the maximum Faraday efficiency (FE) of CH4 reached up to 97.5% on graphite plate. Meanwhile, the maximum acetate yield achieved 1,330 g m-2 d-1 with CO2 conversion efficiency into acetate close to 100% on carbon nanotube cathodes. In photocatalyst-assisted systems, the maximum acetate yield could reach 0.51 g L-1 d-1 with the coulombic efficiency of 96% on the MnFe2O4/g-C3N4 photocathode. Finally, prospects for future development and practical applications of MES are discussed, offering theoretical guidance for the fabrication of cathode materials that can improve production efficiency and reduce energy input.