This new edition offers state-of-the-art chapters by distinguished experts in the field of Hematology. The contributors have critically examined and analyzed into perspective some of the contemporary advances and developments and rising torrent of valuable literature of various aspects of hematology. The text is unique in providing the depth and breadth of knowledge in hematology and also a stimulus for further discussion and future research. A multidisciplinary approach with thought provoking articles on exciting topical issues related to hematology contributed by several experts drawn from I.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder in which the immune system mistakenly produces antiphospholipid antibodies that attack tissues in the body. These antibodies can lead to the formation of blood clots in arteries and veins. During pregnancy, APS can also lead to miscarriage and stillbirth. Classification criteria require a clinical event (i.e., thrombosis or pregnancy complication) and persistent positive blood test results at least three months apart that detect lupus anticoagulant, anti-cardiolipin antibodies, or anti-β2-glycoprotein-1 antibodies. This book addresses important clinical aspects of APS, including stroke and APS, obstetric manifestations of APS, and bleeding complications in APS. It also discusses the diagnostic utility of a novel autoantibody against β2-glycoprotein I/HLA class II complexes as a promising biomarker for APS. Finally, this book also reviews the latest findings in the field of extracellular vesicles in APS and provides explanations of their role in the pathogenesis of APS.

The International Congress on Antiphospholipid Antibodies is held every three years to discuss the recent advances and future directions in Antiphospholipid Syndrome (APS). This volume collects the scientific highlights and new findings about APS that were generated from the most recent 13th Congress, held in Galveston, Texas in 2010. Chapters were written by an internationally-distinguished group of scientists from the point-of-view of multiple specialty areas. Each chapter was written in a uniform and systematic basis to present the latest evidence-based research, including the basic science of APS, task force reports from the Congress on controversial aspects of APS, and future directions of APS research. This book will appeal to all clinicians involved in the treatment and management of APS patients, to residents in a variety of medical subspecialties, and to research scientists interested in a better understanding of this complex and evolving disease.

Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy and memory loss and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, from psychiatry to orthopedics. This book provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved as well as clinical manifestations in both “the thrombotic and “non-thrombotic manifestations of this important disease. Comprehensive review of this major disease Includes information on treatment options available

Recent Advances in Surgery 30 is the latest volume in the successful and well-established Recent Advances series. This title is updated annually, covering the latest trends within surgery and reflecting any changes to the professional examinations for surgeons. Suitable for experienced medical professionals, as well as students and candidates of the MRCS/AFRCS, this edition reviews the latest trends within surgery and forms a useful update of general surgery for candidates of the Intercollegiate examination. Over 30 contributors, who are recognized experts in their particular field, provide in-depth reviews of important topics relevant to the management of all surgical patients and advancing areas in surgical subspecialties.

This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined.This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

Provides an up-to-date review of the surgical progress, Contains the topics important for the surgical practice, Comprises the study material, written, by eminent surgeons and experts in their fields, Includes the chapters on the evidence-based clinical guidelines which are extensively referenced, Proves to be incomparable value to postgraduate students and practicing surgeons. Book jacket.