Zusammenfassung: This book describes the plasmonic photothermal-assisted multimodal cancer therapeutics in the area of cancer nanotechnology or cancer nanomedicine. This book covers the fundamentals of plasmonic photothermal cancer therapy as well as plasmonic photothermal mediated multimodal cancer therapy. The various steps involved in developing such therapeutic modality, viz. (a) the selection of suitable nanoparticles, (b) synthesis of multifunctional nanocomposite, (c) optimization of the photosensitizer and chemotherapeutic drug loadings, (d) characterization of the synthesized nanocomposite, and (e) therapeutic evaluations through novel tumor-tissue mimicking phantoms and the cancer cell lines are discussed in detail. Apart from the detailed description of therapeutic outcome, this book provides a step-by-step approach to develop a multifunctional nanocomposite for such therapeutics. Overall, this book provides simplified and in-depth information about cancer nanobiotechnology to the researchers and graduate students in subject areas of nanotechnology, biotechnology and pharmaceutics to develop and contribute to such multimodal cancer therapeutics

Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which at this moment are in clinical trials phases. This book achieves a state of the art in every field of cancer research and discusses the new perspectives that will open the future for cancer treatment (basic research, new technologies, new drugs, therapies...). For this reason, the book is intended for pathologists, clinicians, and biologists, as well as fellows and students of physiology and medicine.

This brief provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients. Incidents of recurrence are also very common in case of lung cancer. Researchers have shown that nanoparticles may act as a powerful anti cancer tool, especially for lung cancer. Unique surface properties and easy surface functionalization of nanoparticles enable early detection, diagnosis, imaging and treatment of lung cancer. The authors have elaborately presented how various nanoparticles (natural, semi synthetic and synthetic) may help in the treatment of lung cancer. They have also detailed works of various scientists who succeeded in developing effective nanoparticles and enabled very specific lung cancer therapy without any undesirable side effects and minimized death.

Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.

The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.

Breast cancer is one of the most common cancer types worldwide, and is a leading cause of cancer related deaths in women. In this book, medical experts review our current understanding of the molecular biology and characteristics of breast cancer. The topics covered in this book provide comprehensive knowledge of mechanisms underlying breast carcinogenesis, and are intended for a wide audience including scientists, teachers, and students. 11 chapters present information about several topics on breast cancer, including the role of cell growth and proliferation pathways, androgen and cytokine signaling, germline mutations in breast cancer susceptibility genes, and molecular factors causing invasive and metastatic breast cancer. In addition, the editors discuss the recent advancements in multi-omics data analysis based on inter-and intra-tumor molecular profiles. The reference highlights how the knowledge and understanding of the biological behavior of breast neoplasms have facilitated ongoing investigations into dietary polyphenolic compounds with antioxidant properties, making them function as cancer chemopreventive agents. Along with this, the current development of treatment strategies such as targeted molecular therapy, and radiation therapy is brought to the fore to update readers.

This book describes the latest advancements in molecular and cellular engineering approaches in addition to nanotechnology for cancer therapeutics and imaging. It also provides an excellent background and state-of-the-art developments in the fields of drug and gene delivery, engineering nanoparticles for therapy and diagnostics, and cancer imaging techniques.The contents of this book include chapters on cutting-edge science in molecular and cellular engineering and nanotechnology as applied to therapeutics and imaging in cancer diseases. The chapters also provide a comprehensive overview on gene therapy and delivery methods for cancer treatment, oral drug delivery and barriers, cancer imaging for diagnostics and therapy, and the latest developments in these fields.

While it is true that certain types of neoplasms, such as those of the pancreas and brain, are still lesions with a grave prognosis, there are many other common cancers for which appropriate treatment can be curative in substantial numbers of patients ..• This hopeful aspect of cancer is insufficiently appreciated, even by the medical profession itself; too many pessimistic patients find themselves consulting equally pessimistic physicians. WHO Expert Committee on Cancer Treatment *. The aim of this monograph is to present the latest information on the treatment of cancer, and the words quoted above from the report of a WHO Expert Committee on Cancer Treatment form an appropriate introduction to the subject. The pessimism to which they refer is still all too often characteristic of the attitude towards cancer and its treatment. The various chapters have been specially written for this monograph by specialists of international repute, and it will be noted that some of them were participants in the meeting of the WHO Expert Committee on Cancer Treatment mentioned above.

Recent trends in Nanomedicine and Tissue Engineering covers numerous recent technological and research accomplishments in the area of Nanomedicine and Tissue Engineering. The introduction of nanomaterials and nanotechnology have led to crucial advancements in the fields of nanomedicine and tissue engineering, as well as cancer therapies and drug delivery systems.The book follows recent trends in drug delivery systems, wound healing fields, cancer therapies, protection of teeth and also other health care systems.Technical topics discussed in the book include:• Nanorobots• Tissue engineering• Gene therapy• Drug delivery• Nanomotors• Nanogels.