Chemotherapy and/or radiotherapy remain the main treatment options for most cancers. However, cancer treatment is associated with numerous adverse effects, including fatigue, stress, hair loss, pain, nausea, vomiting, anemia, altered immune system, oral and intestinal mucositis, which significantly affect patients' quality of life. In addition, the adverse effects may be associated with additional costs, morbidity, and mortality that affect various aspects of the patient's life, including physical health and emotional state. The management and reduction of adverse effects are extremely important and complex and are primarily aimed at providing comfort to the patient during chemotherapy treatment. In addition, it is important to note that in some cases, the severity of side effects associated with cancer treatment may result in the need to reduce the dose, which in turn may be associated with a reduction in the therapeutic efficacy. In view of this, the identification of new options aimed at alleviating the side effects and increasing the tolerability of chemotherapy is necessary to ensure the quality of life of cancer patients.

In a world grappling with the relentless impact of cancer, claiming nearly 10 million lives in 2020 alone, the pursuit of effective prevention and treatment methods is more crucial than ever. Harnessing Medicinal Plants in Cancer Prevention and Treatment delves into promising medicinal plants, exploring their potential in the prevention and treatment of various types of cancer. Acknowledging the limitations and risks associated with synthetic medicines, the book emphasizes the significance of traditional medicine, revealing that approximately 80% of the global population relies on plant-based remedies for primary health care. Within these pages, readers will find a comprehensive exploration of diverse medicinal plants and their active compounds, unraveling their mode of action against cancer. The content spans continents, from the phytochemical and biological properties of anticancer medicinal plants in India to the role of Chinese and Thai plants in cancer prevention and treatment. Each chapter meticulously examines specific plants or compounds, such as the renowned Curcuma longa, or the intriguing Momordica charantia, providing an in-depth analysis of their anticancer properties. This book elucidates the multifaceted role of plant-derived compounds in various cancer types, addressing their efficacy and safety profiles. The book is rich with insights into the potential of bioactive compounds to serve as lead candidates in drug discovery, highlighting the importance of plants in developing effective anticancer agents. This book is an invaluable resource for a diverse audience, including biotechnologists, plant biologists, pharmacologists, and cancer-related researchers.

Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.

At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Therefore, Frontiers in Immunology is proud to offer this platform to promote the work of women scientists, across all fields of Cancer Immunity and Immunotherapy.

Ovarian Cancer Immunotherapy provides a broad overview of several aspects of basic sciences, and clinical and therapeutic aspects of immunotherapy for ovarian cancer, as well as state-of-the-art information on molecular genetics and biology. Chapters are written by a team of expert contributors from around the world and explore topics such as antibody therapeutics for ovarian carcinoma, emerging serum biomarkers, ovarian cancer immunity, adoptive cell immunotherapy, the biology of dendritic cells, the role of growth factors, and more. Readers will also gain a better understanding of the molecular and cellular events that underlie ovarian cancer immunology. This book is an ideal resource for clinicians, basic medical scientists, graduate basic medical science students, and medical students caring for patients with ovarian cancer, including attending surgeons and physicians, and clinical fellows and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.

A must-have health companion for herbalists, naturopaths, complementary medicine practitioners and students Herbs and Natural Supplements, 3rd Edition: An evidence-based guide presents evidence-based information on the 130 most popular herbs, nutrients and food supplements used across Australia and New Zealand. This exhaustive textbook is organised alphabetically by each herb or nutrient’s common name. Herbs and nutrients are then accompanied by critical information such as daily intake, main actions and indications, adverse reactions, contraindications and precautions, safety in pregnancy and more. This new edition of Herbs and Natural Supplements has been expanded with new chapters on pregnancy and wellness. It also features 10 new monographs for Arginine, Dunaliella, Elde, Goji, Pelargonium, Prebiotics, Red Yeast Rice, Rhodioloa, Shatavari and Taurine. • provides current, evidence-based information on herbal, nutritional and food supplements used in Australia and New Zealand • is user-friendly and easily organised by easy-to-find A-Z herbal monographs • appendices offering important additional information for the safe use of herbal and nutritional supplements, including a list of poison information centres, associations, manufacturers and more • offers clear, comprehensive tables including herb/natural supplement - drug interactions • lists the pharmacological actions of all herbs and natural supplements • a glossary of terms relevant to herbs and natural supplements • two comprehensive new chapters: Herbs and Natural Supplements in Pregnancy and Introduction to Wellness • all chapters completely updated and expanded • ten new monographs taking the total to 130 • now also available as an eBook! A code inside Herbs and Natural Supplements, 3rd Edition: An evidence-based guide enables a full text download, allowing you to browse and search electronically, make notes and bookmarks in the electronic files and highlight material

Immunotherapy is a clinically proven concept to prevent and treat diverse diseases. Therapeutic monoclonal antibodies (mAb) have transformed cancer patient survival and the quality of life for patients with inflammatory and autoimmune diseases. Vaccination with attenuated viruses or microbial virulence factors is a validated strategy to control infectious disease and has eradicated the global pandemic Smallpox infection. Recently, the concept of encoding transgenes, such as the receptor-binding COVID-19 spike protein, cytokines, antibodies, or immunogenic tumor antigens into non-viral or viral vectors has been validated as a powerful means to achieve vaccination for protection against pandemic infections, and cancer immunotherapy respectively. For certain immunotherapeutic targets and mechanisms, vector-based targeting offers distinct advantages over the traditional protein format. For example, in cancer immunotherapy vectorization may enable local delivery, production, and tumor-enriched exposure of powerful immune-modulatory antibodies, for example anti-CTLA-4 or anti-CD28 that are too toxic to allow full therapeutic dosing upon systemic administration.

Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients' overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. - Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments - Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities - Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research