This issue of Otolaryngologic Clinics, guest edited by Drs. Sarah K. Wise, Ashkan Monfared, and Nicole C. Schmitt is devoted to Biologics in Otolaryngology. This issue is one of six selected each year by our series consulting editor, Dr. Sujana S. Chandrasekhar. Articles in this issue include: Biologics in otolaryngology overview, Current evidence for biologic therapy in chronic rhinosinusitis with nasal polyposis, Choosing the right patient for biologic therapy in CRSwNP, Knowledge gaps and research needs for biologic therapy in rhinology practice, Mechanisms and practical use of biologic therapies for allergy and asthma indications, Immunotherapeutic strategies in head and neck cancer, Cetuximab in head and neck cancer, Anti-PD-1 immune checkpoint blockade for head and neck cancer, Advances in adoptive cell therapy for head and neck cancer, Biologics for the treatment of recurrent respiratory papillomatosis, Past and future biologics for otologic disorders, Biological treatments for Neurofibromatosis Type II and other skullbase disorders, and Biologics in treatment of autoimmune ear disorders.

In this issue of Otolaryngologic Clinics, guest editors Drs. Devyani Lal, Angela Donaldson, and David Jang bring their considerable expertise to the topic of Unified Airway Disease. Unified airway disease is a recently defined entity that alludes to inflammation disease processes that involve both upper and lower airway, and co-management of these conditions by otolaryngologists and allergy immunologists often result in improved outcomes. In this issue, experts in the field provide a thorough overview of the pathophysiology, diagnosis, and management of unified airway disease through the perspective of an otolaryngologist co-managing the patient with an allergy-immunology colleague. - Contains 16 practice-oriented topics including environmental factors; eosinophilic disease; non-eosinophilic and granulomatous disease; cystic fibrosis; pediatric unified airway disease; unified airway disease medical and surgical management; future directions; and more. - Provides in-depth clinical reviews on unified airway disease, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Otolaryngologic Clinics, Guest Edited by Murugappan Ramanathan Jr. and James Whitman Mims, is devoted to Allergy for the Otolaryngologist. Articles in this issue include: New Horizons in the Management of Allergy; The Role of the Sinonasal Epithelium in Allergy; The Role of Allergy in Chronic Rhinosinusitis; Manifestations of Inhalant Allergies Beyond the Nose; The Role of Allergy in Otologic Disease; Asthma Management for the Otolaryngologist; Rational Approach to Allergy Testing (in vitro/in vivo); Advances in Food Allergy; Contemporary Pharmacotherapy of Allergic Inflammation; Clinical Applications of SLIT; Efficacy of SLIT/SCIT; Immunotherapy: Treating with Fewer Allergens?; Management of Anaphylaxis; and Future Horizons in Allergy.

This issue of Immunology and Allergy Clinics, guest edited by Sandra Y. Lin, MD, will provide up-to-date clinical concepts regarding the diagnosis and management of the patient with Rhinosinusitis. Articles in this outstanding issue include: Current Concepts in the Management of Allergic Fungal Sinusitis; Aspirin Desensitization for Nasal Polyps in Aspirin-exacerbated respiratory disease (AERD); Primary Immunodeficiency and Rhinosinusitis; How to Measure Success in the Treatment of Patients with Chronic Rhinosinusitis; What is the Role of Macrolides and Doxycyline in Chronic Rhinosinusitis?; The Role of Biologics in the Treatment of Nasal Polyps; Personalized Medicine in Chronic Rhinosinusitis: Endotypes, Phenotypes, and Biomarkers; Management of Sinusitis in the Cystic Fibrosis Patient; The Microbiome and Chronic Rhinosinusitis; The Role of Allergic Rhinitis in Rhinosinusitis; The Role of Air Pollution in Chronic Rhinosinusitis; Odontogenic Sinusitis: Current Concepts in Diagnosis and Treatment; Olfactory Dysfunction and Chronic Rhinosinusitis; and The Impact of Allergen Immunotherapy on Chronic Rhinosinusitis.

This issue of Otolaryngologic Clinics, guest edited by Drs. Jean Anderson Eloy and Michael Setzen, is devoted to the Contemporary Management of Frontal Sinusitis. Articles in this outstanding issue include: Overview of Frontal Sinus Management; Evaluation and Decision-Making in Patients with Frontal Sinusitis; Medical Management of Frontal Sinusitis; Surgical Anatomic Consideration in Frontal Sinus Surgery; Instrumentation in Frontal Sinus Surgery; Preventing and Managing Complications in Frontal Sinus Surgery; Frontal Sinus Balloon Dilation; Utility of Image-Guidance in Frontal Sinus Surgery; Standard Endoscopic Approaches in Frontal Sinus Surgery: Technical Pearls and Approach Selection; Modification of the Standard Frontal Sinus Endoscopic Approaches; Outcomes after Frontal Sinus Surgery: An Evidence-Based Review; Management of Frontal Sinus Cerebrospinal Fluid Leaks and Encephaloceles; Management of Frontal Sinus Tumors; and Open Frontal Sinus Surgery.

In this issue of Pediatric Clinics of North America, guest editors Drs. Huma Quraishi and Michael Chee bring their considerable expertise to the topic of Pediatric Otolaryngology. National health statistics indicate that disorders of the ear, nose, and throat are among the primary reasons children visit a physician, with ear infections ranking as the number one reason. This issue provides a comprehensive overview of otolaryngologic issues affecting children, providing the clinical information pediatricians need to make prompt diagnoses and facilitate positive patient outcomes. - Contains 14 relevant, practice-oriented topics including otitis media and myringotomy tubes; congenital sensorineural hearing loss; tethered oral tissue/ankyloglossia/tongue and lip tie; adenotonsillectomy; pediatric obstructive sleep apnea syndrome; recurrent croup; and more. - Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Drs. Joni K. Doherty and Michael Setzen bring their considerable expertise to the topic of Comprehensive Management of Headache for the Otolaryngologist. As many types of headache tend to masquerade as sinus headache, an understanding of the peripheral mechanisms of specific headache types is essential for otolaryngologists to effectively diagnose and treat patients, according to a study published in the American Journal of Otolaryngology. In this issue, top experts in the field address key issues such as novel devices for sinus headache, headache diagnosis in children and adolescents, headache and pregnancy, side-locked and nummular headaches, and much more. - Contains 14 relevant, practice-oriented topics including the role of the otolaryngologist in the evaluation and management of headache; "Sinus headache: rhinogenic headache, nonrhinogenic headache, or migraine; idiopathic intracranial hypertension; neuralgia and atypical facial, ear, and head pain; and more. - Provides in-depth clinical reviews on comprehensive management of headache, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This issue of Otolaryngologic Clinics, guest edited by Drs. Abtin Tabaee and Edward D. McCoul, is devoted to Refractory Chronic Rhinosinusitis. Articles in this issue include: Classification of Chronic Rhinosinusitis: Working Towards Personalized Diagnosis; Bacterial Pathogens and the Microbiome; Biofilm and Osteitis; Refractory Chronic Sinusitis with Polyposis; Aspirin-Exacerbated Respiratory Disease; Systemic and Odontogenic Etiologies in Chronic Rhinosinusitis; Genetic and Immune Dysregulation in Chronic Rhinosinusitis; Office Procedures in Refractory Chronic Rhinosinusitis; Topical Therapies and Stents; Revision Functional Endoscopic Sinus Surgery; Extended Endoscopic and Open Sinus Surgery for Refractory Chronic Rhinosinusitis; and An Algorithm for Comprehensive Evaluation and Management of Refractory Chronic Rhinosinusitis.

In this issue of Medical Clinics, guest editor Daniel M. Goodenberger brings his considerable expertise to the topic of Pulmonary Diseases. - Provides in-depth reviews on the latest updates in Pulmonary Diseases, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

In this issue of Otolaryngologic Clinics, guest editors Stacey L. Ishman, Carol Li, and Reena Dhanda Patil bring their considerable expertise to the topic of sleep apnea. This issue provides a timely and relevant update regarding the treatment of sleep patients as the Otolaryngology community witnesses an increasing prevalence in sleep-disordered breathing. This affects millions worldwide, and it is evident that sleep disorders impact both individual health and societal well-being. - Contains 14 relevant topics including Health Inequalities in the Diagnosis and Treatment of Obstructive Sleep Apnea in Children and Adults; Home Sleep Testing versus Traditional Polysomnography; Comorbid Insomnia and Sleep Apnea; Management of Obstructive Sleep Apnea in the Infant and Newborn; and more. - Provides in-depth clinical reviews on sleep apnea, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.