This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.

Stroke continues to be a major public health issue. It is the third leading cause of death and disability across the globe. Its early identification and treatment along with prevention are major issues that confront a treating physician. We have understood the importance of early intervention and of the quote ‘time is brain’. Our endeavor now should be directed to the public at large and paramedics in particular. Although a stroke is a common condition, the availability of neurologists or stroke specialists is quite scarce. Today, management of a suspected case of stroke is done by a specialist team of medical and paramedical personnel. Advances in imaging, newer therapeutic agents, and endovascular management have revolutionized the management. Currently, we are witnessing a new era in the management of strokes and I am hopeful that continued research will get us to a satisfactory solution. This book along with another book from IntechOpen titled ‘Ischemic Stroke of Brain’ aims to improve the understanding of stroke medicine for postgraduate medical students in medicine and neurology who have an interest in stroke care.

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. - Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials - Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis - Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI - Covers the prevailing opinions on how to harness the body's natural repair mechanisms - Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Regenerative medicine is a fast developing field which has led to a paradigm shift in treatment of various diseases. Clinician-scientists worldwide constantly develop novel approaches in various medical specialties (surgery, internal medicine, oncology, neurology, gynecology, pediatrics, etc.) using gene therapy approaches, innovative biomaterials or stem cell based therapies.It is difficult even for experts to find out what has already reached a clinical stage. The aim of the second volume in this series is to provide the reader with a current update on the latest therapeutic developments. As such, both patients and doctors will find the information contained within this manual to be useful and relevant. The editors are both international leaders in the field of regenerative medicine, and both possess a broad spectrum of experience from basic research to clinical application and commercialization.

Stroke is one of the leading causes of death and disability worldwide. Among them, ischemic stroke is attributed to an abrupt blockage of blood flow to brain, while hemorrhagic stroke is caused by bleeding into brain. The principal aim of stroke therapy is to decrease mortality and reduce persistent neurologic injury and long-term disability. It also targets to prevent complications and recurrence after stroke as well as minimize the brain function loss caused by the cerebral damage. Fortunately, many strokes could be prevented through healthy lifestyle changes and controlling stroke risk factors, such as cigarette or tobacco smoking, high blood pressure, diabetes, and heart disease. Carotid endarterectomy and stenting of the cervical and intracranial vessels may help reduce recurrent stroke in some cases. Advanced treatments and rehabilitation are helping many stroke patients return to society and their families.

Prevalence of brain related diseases is expected to increase significantly in the next decades. Therefore, there is a vital need to develop effective, personalized models of human brain that can provide information about brain development, and the unique neurobiology of brain disorders. The use of biomaterials can play a strategic role for the future understanding and treatment of complex CNS diseases. Three-dimensional brain cultures have shown promise in disease modelling, cell transplantation and modulation of tissue repair.

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. - Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery - Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs - Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine