developed. When I did not identify European colleagues In this rapidly evolving field it is appropriate to update frequently our state of the art knowledge of uremia therapy. who had the expertise who could expend the time and with Hence, this third edition of Replacement of Renal Function whom I could work so smoothly, I began alone. by Dialysis appears before many of its predecessors have Although I was tempted to ask all the same authors as had been destroyed by normal wear and tear over 11 and 6 years written so well previously to contribute again, I realized that the new edition must be revitalized. Accordingly a fraction of use, respectively. The first two editions of this book were designed to be of the authors changed, some new topics have been added integrated comprehensive reviews of the pertinent aspects and others have been deleted. The multinational character of dialysis and related fields with sufficient clarity for the of authorship has been maintained. Existing chapters have novice to learn, yet adequate depth for the expert to rely on been rewritten thoroughly, and new authors have provided them as encyclopedic desk references on renal replacement as requested a full discussion and bibliography in keeping therapy. Based on the favorable readers' comments and with the previous editions.

Completely revised edition of a global resource first published in 1978 and previously revised in 1989. Sixty-three contributions are arranged in sections on the pathophysiology of the uremic syndrome--principles and biophysics of dialysis; technology of dialysis and associated methods; quantification and prescription; complications; pharmacological considerations; special clinical situations; organ system and metabolic complications; and organization and results of chronic dialysis. The aim is to give understanding of the complexities of modern dialysis apparatus so that practitioners can make the best use of the technology--and so that fledgling nephrologists can avoid the temptation to by-pass the theory and the nuances. Annotation copyright by Book News, Inc., Portland, OR

The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester. This new edition is truly global in scope and features the contributions of the top experts from around the world.

BELDING H. SCRIBNER The year was 1942 and Will em Kolff was hard at 60's, we encountered exactly the same kind of work perfecting the device that would not only resistance to the concept of chronic dialysis. But revolutionize the treatment of renal failure, but as has happened over and over again in all of more importantly point the way to the develop science, the heresy of one decade becomes the ment of the entire field of extracorporeal devices practice of the next - a phenomenon that the in general and cardiac bypass devices in particular. young heretics among the third generation readers The enormity of the impact that Kolffs con of this volume should not forget. tribution was to have on medicine was revealed And so, today Drukker, Parsons and Maher retrospectively to me when I recalled that in that have successfully undertaken the very difficult same year, 1942, I was a second year medical task of bringing together in one volume all the student at Stanford University, taking among diverse elements of dialysis therapy. The size of other things, P. J. Hanzlik's required course in the volume reflects not only the magnitude ofthe pharmacology. I have two memories of that interdisciplinary effort that brought about the course. One was the requirement that we students technical and clinical advances, but also the learn to recognize 64 old time drugs by appear many clinical and other ramifications of dialysis ance, smell and taste. For better or worse, almost therapy.

More than 50 years after Haas' first human dialysis, and second edition by incorporating chapters on its history 40 years after Kolfrs pioneering work, a book on the and on the practical aspects. present state of the art cannot be written by one person: The size of the book has almost doubled, partly by obviously it had to be a multi-authored volume. There using more illustrations. The inclusion of a number of fore some overlap between chapters and even a few con colour reproductions has been made possible by a sup troversies between authors became unavoidable. porting grant * of the National Kidney Foundation of we deliberately avoided editorial streamlin the Netherlands, which the editors gratefully acknow However ing of manuscripts, leaving the authors' personal style ledge. We considered asking several authors to shorten their and personal opinions unaltered as much as possible. We resisted this as it would have delayed the This may make the book more vivid to read and may chapters. sometimes stimulate readers to study a subject in greater publishing date and would possibly have removed much detail from the literature. Additionally, both British and material besides being a painful task for our collea American spellings have been kept because of the inter gues.

**Selected for Doody's Core Titles® 2024 in Transplantation Surgery** From basic science to practical clinical tools, Chronic Kidney Disease, Dialysis, and Transplantation, 4th Edition provides you with the up-to-date, authoritative guidance you need to safely and effectively manage patients with chronic renal disease. Covering all relevant clinical management issues, this companion volume to Brenner and Rector's The Kidney presents the knowledge and expertise of renowned researchers and clinicians in the fields of hemodialysis, peritoneal dialysis, critical care nephrology, and transplantation – for an all-in-one, indispensable guide to every aspect of this fast-changing field. - Contains expanded content on economics and outcomes of treatment, as well as acute kidney injury. - Covers hot topics such as the genetic causes of chronic kidney disease, ethical challenges and palliative care, and home hemodialysis. - Discusses the latest advances in hypertensive kidney disease, vitamin D deficiency, diabetes management, transplantation, and more. - Provides a clear visual understanding of complex information with high-quality line drawings, photographs, and diagnostic and treatment algorithms. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

The importance of peritoneal dialysis (PD) in the therapy of chronic kidney disease has been steadily increasing. The simultaneous advancement in clinical practice and basic research has increased overall knowledge and led to significant progress in the safe and adequate application of PD. Moreover, integration with other techniques in the therapy of uremia represents an important step in the optimization of the whole program of renal replacement therapy.Leading experts in the field have contributed to this volume, discussing topics such as the biology of the peritoneal membrane, dialysis solutions, inflammation and nutrition, PD adequacy, or complications and their management or PD in special settings. This compilation updates and expands the information on PD published in previous volumes of the series 'Contributions to Nephrology'. It represents an important source of information for beginners and experts, basic scientists and clinical physicians, students and investigators who want to have a true update on current research and clinical practice in peritoneal dialysis.

The only book of its kind, this essential reference offers quick access to information on the effects medical conditions can have on pregnancy and childbirth. Coverage includes a brief overview of normal anatomy and physiology with concise, practical guidelines for managing disorders commonly seen in women of childbearing age. From mild diseases such as asthma to serious conditions such as heart lesions, this indispensable guide will help you manage pregnancy and childbirth in women with systemic disease, recognize the early onset of disease-related pregnancy complications, and determine when it may be necessary to refer patients to a specialist. - Offers complete coverage of normal pathophysiology in both the general population and in the context of pregnancy and childbirth. - Provides comprehensive midwifery management guidelines. - Outlines potential consequences of disease-related complications for the fetus or neonate.