Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neurons control the legs. The signs described above can occur in any muscle group, including the arms, legs, torso, and bulbar region. Symptoms usually present between the ages of 50-70, and include progressive weakness, muscle wasting, and muscle fasciculations; spasticity or stiffness in the arms and legs; and overactive tendon reflexes. Patients may present with symptoms as diverse as a dragging foot, unilateral muscle wasting in the hands, or slurred speech. This new book presents the latest research from around the globe.

This book presents new research on cognitive science which is most simply defined as the scientific study either of mind or of intelligence. It is an interdisciplinary study drawing from relevant fields including psychology, philosophy, neuroscience, linguistics, anthropology, computer science, biology, and physics. There are several approaches to the study of cognitive science. These approaches may be classified broadly as symbolic, connectionist, and dynamic systems. Symbolic holds that cognition can be explained using operations on symbols, by means of explicit computational theories and models of mental (but not brain) processes analogous to the workings of a digital computer. Connectionist (subsymbolic) holds that cognition can only be modelled and explained by using artificial neural networks on the level of physical brain properties. Hybrid systems hold that cognition is best modelled using both connectionist and symbolic models, and possibly other computational techniques. Dynamic Systems hold that cognition can be explained by means of a continuous dynamical system in which all the elements are interrelated, like the Watt Governor. The essential questions of cognitive science seem to be: What is intelligence? and How is it possible to model it computationally?

Alzheimer's disease is a particularly insidious affliction that profoundly affects the patient as well as family and friends. Written by a distinguished group of researchers and clinicians, Progress in Alzheimer's Disease and Similar Conditions provides medical professionals who investigate and treat brain diseases with updated research findings and their implications. This treasury of clinical and research expertise presents important findings in genetics, epidemiology, pathology, pharmacology, and pathophysiology. This book covers a range of important issues, from basic clinical science to pharmacology and social support. In particular, Dr. Heston's book details the spectacular advances in research on human genetics that are broadening our knowledge of Alzheimer's disease and other related afflictions and that have profound implications for both clinical practice and further research. Two chapters describe disease mechanisms, including prions, that provide important insights into the role environment plays in the development of disease. Other chapters highlight the clinical challenges that Alzheimer's disease presents, including stories about the pain inflicted by this disease on the patients and their families and friends, as well as current efforts in management and treatment.

These proceedings deal with the future prospective of nuclear medicine in various disciplines such as Neurology, Cardiology and Oncology. Nuclear medicine is now shifting from functional, metabolic imaging to molecular imaging. Molecular imaging by labelled compounds has a brilliant future in the era of gene therapy. In conclusion, we may say that the future of nuclear medicine is still scintillating!

Die zwolfte Auflage des beliebten Standardwerks bietet den neuesten Stand der klinischen und apparativen Diagnostik, der Pathophysiologie und der konservativen sowie der interventionellen Therapie. Das Lehrbuch besticht durch ein ebenso ansprechendes wie didaktisch ausgefeiltes Layout. Der flussig und verstandlich geschriebene Text der renommierten Autoren bringt auch komplexe Zusammenhange auf den Punkt. Pointierte Einleitungen, anschauliche Fallberichte, viele Merksatze sowie strukturierte Kapitelzusammenfassungen erleichtern das Lernen und bieten intensive Orientierung. Besonderer Pluspunkt: Facharztwissen und Leitlinien der DGN in Boxen herausgestellt. Wer uber den Tellerrand der MC-Prufungen hinausblicken und sich fundierte Kenntnisse der Neurologie aneignen mochte, ist mit diesem Lehrbuch gut beraten. Auch fur Assistenzarzte in der Facharztweiterbildung sehr geeignet.