The Codex Committee on Food Labelling (CCFL) requested scientific advice as to whether certain foods and ingredients, such as highly refined foods and ingredients, that are derived from the list of foods known to cause hypersensitivity can be exempted from mandatory declaration. The objective of this fourth meeting was to expand on the recommendations from the first meeting concerning derivatives of food allergens and establish a framework for evaluating exemptions for food allergens. A pro forma process has been developed and tested against allergen derivatives previously granted exemptions in various countries or regions and found to be effective for consideration in future exemption decisions. The Expert Committee recommends that the process outlined in the pro forma process be used to guide any future development and evaluation of derivative exemptions. Establishment of safety based upon this weight of evidence approach is dependent upon consideration of data quality, outcome of the exposure assessment for all intended ingredient uses (specified for exemption), and review by competent authorities (as needed). When safety is established, exemption can be justified.

The labelling of food allergens in pre-packaged foods plays a key role in protecting food allergic individuals, as no preventative clinical treatment is currently available. The list of major foods and ingredients known to cause hypersensitivity was included into the Codex General Standard for the Labelling of Packaged Foods (GSLPF) in 1999. There have been many scientific developments in the understanding of food allergens and their management since the original drafting of the GSLPF. Thus, in response to the request from Codex for scientific advice, including current evidence of consumer understanding of allergens, FAO and WHO convened a series of three expert meetings to provide scientific advice on this subject. The purpose of the first meeting of the Ad hoc Joint FAO/WHO Expert Consultation on Risk Assessment of Food Allergens was to review and validate the Codex priority allergen list through risk assessment. This report focuses on the deliberations and conclusions of this meeting.

FAO and WHO reconvened a third meeting to review and evaluate the evidence in support of precautionary allergen labelling to address unintended allergen presence in foods. The Expert Committee at the third meeting reviewed the data on the current status and uses of the precautionary allergen labelling (PAL) and unanimously agreed that current PAL systems used in many countries needed to be improved as they were neither uniform nor informative and were not consistently risk based on amount and frequency of UAP found in food products. The Expert Committee also found that current PAL approaches led to widespread PAL that diminished information and value for consumers. The Expert Committee reviewed again the principles and basis of RfD from the second meeting and reached a consensus that the RfD for each priority allergen, as described by the HBGV and safety objectives, was a valid risk assessment endpoint for determining when sporadic or unexpected UAP posed more than appreciable risk to consumers and needed to be communicated to consumers by PAL.

The report of the first Joint FAO/WHO Expert Consultation on the Risks and Benefits of Fish Consumption was published in 2010. Since then, new literature, data and information on the subject have become available. As such, FAO and WHO decided to generate a background report consisting of a comprehensive literature review, followed by an expert consultation, to update the report with new scientific evidence. This background document aims to provide scientific evidence about the risks and benefits of fish consumption in order to update the 2010 Report of the Joint FAO/WHO Expert Consultation on the Risks and Benefits of Fish Consumption. To provide new scientific evidence, five extensive literature reviews were conducted, focusing on the following five topics: 1. evidence of health benefits from fish consumption; 2. toxic effects of dioxins and dioxin-like polychlorinated biphenyls (dl-PCBs) (from studies published since 2010); 3. toxic effects of methylmercury (MeHg) (from studies published since 2010); 4. the role of selenium (Se) with regard to the health effects of MeHg; 5. occurrence data for MeHg, dioxins and dl-PCBs in fishery and aquaculture products (from studies published since 2010). The reviews followed a systematic approach, performing a systematic literature search and implementing elements from systematic literature reviews. A systematic review attempts to identify, appraise and synthesize all the empirical evidence that meets prespecified eligibility criteria to answer a specific research question.

Agrifood systems require sustained growth to maintain food security for the global population, while facing unprecedented pressure from challenges of climate change and resource depletion. In this context, evaluating, holistically planning and transitioning to circularity will be critical to improve sustainability and face those challenges. While circular economy initiatives offer considerable promise in improving sustainability and increasing performance, these benefits are juxtaposed by the increasing evidence that contaminants, physical, microbiological or chemical, can get introduced, persist and potentially lead to unsafe food. Therefore, protecting food safety is key for the success of transitioning our current linear agrifood system to a more sustainable and circular one. This report provides a synthesis of current and emerging evidence of food safety risks in circular agrifood initiatives, with an aim to understand challenges and opportunities to manage and enhance food safety. Food safety has to be an equal performance indicator for any transition, requiring addressing data gaps, focusing research efforts and exploring opportunities for improving food safety outcomes. All parties in the agrifood system need to proactively do their part to ensure agrifood systems develop, by harnessing the innovation in this area, and at the same time produce safe food.

Lipid-based nutrient supplements (LNS) and ready-to-use therapeutic food (RUTF) are used to prevent and treat malnutrition in children. [Author] They are often produced in regions experiencing food insecurity and include edible oils obtained from oleaginous seeds or fruits that must be refined to remove undesirable substances and ensure adequate shelf-life for the product. [Author] However, the formation of the heat-induced contaminants 3-monochloropropane-1,2-diol (3-MCPD) fatty acid esters and glycidyl fatty acid esters (GEs) may occur during the refining process of edible oils. [Author] 3-MCPD and its fatty acid esters are present in many other foodstuffs and most of the total lifetime exposure is attributed to foods other than LNS/RUTF. [Author] While the only Codex standard developed for 3-MCPD is for liquid condiments containing acid hydrolyzed vegetable proteins, no Codex standards are available for GEs. [Author] This publication provides an overview of risk assessments for 3-MCPD and GEs previously performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), European Food Safety Authority (EFSA) and other authorities, based on chronic exposure. [Author] The use of LNS/RUTF is intended to be of finite duration and confined to a specific life stage. [Author] The aim of this report was to provide an assessment to characterize the risk of less-than-lifetime exposure to 3-MCPD (including 3-MCPD fatty acid esters) and GEs via LNS/RUTF in the context of limited food availability. [Author] The thresholds identified herein for concentrations of 3-MCPD and glycidol equivalents in LNS/RUTF products are considered to represent a level of exposure that is of low concern for human health. [Author]

Evolving science and debate concerning the benefits and risks of consuming fish have resulted in confusion over the years, and national and international food safety agencies have recognized the need to provide useful, clear and relevant information in this regard to consumers. In October 2023, FAO and WHO held the second Joint FAO/WHO Expert Consultation on the Risks and Benefits of Fish Consumption to analyse new scientific evidence on the matter and draw relevant conclusions and recommendations. The overall conclusions of the exercise show that consuming fish provides energy, protein and a range of other nutrients important for health, and that there are benefits related to fish consumption during all life stages (pregnancy, childhood and adulthood). General population studies show that the benefits and individual effects of fish consumption vary depending on overall diet, the characteristics of consumers, and the fish that is consumed.