Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling,

Many plant-derived bioactive compounds are the foundation for drugs or effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limited th Introduces the scale-up and chemical process development for microbial production of plant-derived bioactive compounds Covers the useful and effective sustainable and commercial production of plant-derived bioactive compounds Provides a guide for commercial production of plant-derived bioactive compounds and their uses for human welfare

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. - Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up - Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch - Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation - Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

"Written by engineers for engineers (with over 150 International Editorial Advisory Board members),this highly lauded resource provides up-to-the-minute information on the chemical processes, methods, practices, products, and standards in the chemical, and related, industries. "

The past, present, and future of green chemistry and green engineering From college campuses to corporations, the past decade witnessed a rapidly growing interest in understanding sustainable chemistry and engineering. Green Chemistry and Engineering: A Practical Design Approach integrates the two disciplines into a single study tool for students and a practical guide for working chemists and engineers. In Green Chemistry and Engineering, the authors—each highly experienced in implementing green chemistry and engineering programs in industrial settings—provide the bottom-line thinking required to not only bring sustainable chemistry and engineering closer together, but to also move business towards more sustainable practices and products. Detailing an integrated, systems-oriented approach that bridges both chemical syntheses and manufacturing processes, this invaluable reference covers: Green chemistry and green engineering in the movement towards sustainability Designing greener, safer chemical synthesis Designing greener, safer chemical manufacturing processes Looking beyond current processes to a lifecycle thinking perspective Trends in chemical processing that may lead to more sustainable practices The authors also provide real-world examples and exercises to promote further thought and discussion. The EPA defines green chemistry as the design of chemical products and processes that reduce or eliminate the use or generation of hazardous substances. Green engineering is described as the design, commercialization, and use of products and processes that are feasible and economical while minimizing both the generation of pollution at the source and the risk to human health and the environment. While there is no shortage of books on either discipline, Green Chemistry and Engineering is the first to truly integrate the two.

With a focus on actual industrial processes, e.g. the production of light alkenes, synthesis gas, fine chemicals, polyethene, it encourages the reader to think “out of the box” and invent and develop novel unit operations and processes. Reflecting today’s emphasis on sustainability, this edition contains new coverage of biomass as an alternative to fossil fuels, and process intensification. The second edition includes: New chapters on Process Intensification and Processes for the Conversion of Biomass Updated and expanded chapters throughout with 35% new material overall Text boxes containing case studies and examples from various different industries, e.g. synthesis loop designs, Sasol I Plant, Kaminsky catalysts, production of Ibuprofen, click chemistry, ammonia synthesis, fluid catalytic cracking Questions throughout to stimulate debate and keep students awake! Richly illustrated chapters with improved figures and flow diagrams Chemical Process Technology, Second Edition is a comprehensive introduction, linking the fundamental theory and concepts to the applied nature of the subject. It will be invaluable to students of chemical engineering, biotechnology and industrial chemistry, as well as practising chemical engineers. From reviews of the first edition: “The authors have blended process technology, chemistry and thermodynamics in an elegant manner... Overall this is a welcome addition to books on chemical technology.” – The Chemist “Impressively wide-ranging and comprehensive... an excellent textbook for students, with a combination of fundamental knowledge and technology.” – Chemistry in Britain (now Chemistry World)

Process Technology provides a general overview about chemical and biochemical process technology. It focuses on the structure and development of production processes, main technological operations and the important aspects of process economics. The theoretical foundations in each chapter are supplemented by case studies and examples in a clear and instructive manner to illustrate the practical aspects. The author highlights operating principles, reasons for application and available industrial equipment of technological operations. Aim is to facilitate those without a process technology background in multi-disciplinary cooperation with (bio-) chemical engineers by providing an overview of this exciting field. The textbook is organized into seven distinct parts: Structure of the chemical industry and (bio-) chemical processes (Bio-) Chemical reaction engineering Molecular separations (distillation, extraction, absorption, adsorption) Mechanical separations (filtration, sedimentation, membranes) Particle and final product manufacturing Development, scale-up, design and safety of processes Major industrial process descriptions

Common scale-up methods are conventional where the blind piloting is essential. This imposes huge investment and leads to failures mostly in solid processing. However, the limitations of resources, current shortcomings, short time-to-market demand are forced companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences:

Ludwig's Applied Process Design for Chemical and Petrochemical Plants Incorporating Process Safety Incidents is ever evolving starting with the first edition some 60 years ago. The volumes in this fifth edition provide improved techniques and fundamental design methodologies to guide the practicing engineer in designing process equipment and applying chemical processes to the properly detailed hardware. As indicative of the new title, process safety incidents are incorporated in many of the chapters, reviewing the root causes, and how these could be mitigated in future. Like its predecessor, this new edition continues to present updated information for achieving optimum operational and process conditions and to avoid problems caused by inadequate sizing and lack of internally detailed hardware. The volumes provide both fundamental theories where applicable and direct application of these theories to applied equations essential in the design effort. This approach in presenting design information is essential for troubleshooting process equipment and in executing system performance analysis. Volume 1B continues to cover mixing of liquids, process safety and pressure[1]relieving devices, metallurgy and corrosion, and process optimization. It builds upon Ernest E. Ludwig's classic text to further enhance its use as a chemical engineering process design manual of methods and proven fundamentals. This new edition includes new content on three-phase separation, mixing of liquids, ejectors, and mechanical vacuum systems, process safety and pressure-relieving devices, metallurgy and corrosion, and optimization of chemical process/blending. Some chapters review pressure-relieving devices and provide case studies for process safety incidents, which are well illustrated from US Chemical Safety Hazard Investigation Board (www.csb.gov). Finally, this book contains a glossary of Petroleum and Petrochemical Terminologies and Physical and Chemical Characteristics of Major Hydrocarbons.? Provides improved design manual for methods and proven fundamentals of process design with related data and charts? Covers complete range of basic day-to-day petrochemical operation topics? Extensively revised with new material added on three-phase separation, metallurgy, and corrosion? Process safety management/HAZOP and hazard analyses, and optimization of chemical process/blending? Presents many examples using Honeywell UniSim Design software, developed and executable computer programs, and Excel spreadsheet programs? Includes case studies of process safety incidents, guidance for troubleshooting, and checklists? Includes Software of Conversion Table and 30+ process data sheets in excel format