An understanding of mechanisms underlying seizure disorders depends critically on the insights provided by model systems. In particular with the development of cellular, molecular, and genetic investigative tools, there has been an explosion of basic epilepsy research. Models of Seizures and Epilepsy brings together, for the first time in 30 years, an overview of the most widely-used models of seizures and epilepsy. Chapters cover a broad range of experimental approaches (from in vitro to whole animal preparations), a variety of epileptiform phenomenology (including burst discharges and seizures), and suggestions for model characterization and validation, such as electrographic, morphologic, pharmacologic, and behavioral features. Experts in the field provide not only technical reviews of these models but also conceptual critiques - commenting on the strengths and limitations of these models, their relationship to clinical phenomenology, and their value in developing a better understanding and treatments. Models of Seizures and Epilepsy is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models for addressing key questions in the field. It also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research. - The first comprehensive description of animal models of epilepsy since the early 1970's - Comprehensive analysis of "What the models model" to guide the selection of each model, and what specific questions it will answer - Elegant examples of the use of novel technologies that can be applied in experimental epilepsy research - World expert opinions on the clinical relevance of each model

Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this volume covers the scientific basis, clinical diagnosis, and treatment of epilepsy and epileptic seizures, and is complemented by an online edition.

"Electroencephalography (EEG) is an invaluable tool for evaluating patients with suspected seizures or encephalopathy, yet EEG is only one source of data, so information from this technology must be integrated with knowledge of basic science and clinical neurology. This work has a principal focus on EEG, but interleaves that discussion with information on seizures, epilepsy, encephalopathy, and other neurologic conditions for which EEG can be a useful diagnostic tool"--

Affecting 4 percent of children and 1-2 percent of the general population, epilepsy is one of the most common neurological disorders. The 1st edition of this guide proved to be the only one of its kind, covering many important aspects of diagnosis and treatment. Due to the continued advances being made in the subject, and building on the sell-out success of the 1st edition this thorough revision reflects the latest report of the ILAE classification core group and the significant progress made in the diagnosis, classification and treatment of the epilepsies.

The most important advance in recent epileptology is the recognition of epileptic syndromes and diseases, most of which are well defined and easy to diagnose. The benign childhood partial seizures syndromes exemplify the importance of a precise diagnosis and classification of epilepsies. They are common, and have an excellent prognosis which is better than that of febrile convulsions. Paediatricians and clinical neurophysiologists are now familiar with the Rolandic seizures but are not yet accustomed to diagnosing other benign childhood partial seizures and in particular benign childhood occipital seizures which are often confused with cerebral insults or migraine. The aim of this reference book is to describe the clinical and EEG manifestations of benign childhood partial seizures with particular emphasis on the occipital seizures which are often more characteristic, easier to diagnose and, in some cases, more benign than Rolandic seizures.

Epilepsy is a common condition where sudden bursts of electrical activity in the brain cause seizures or fits. There are lots of possible symptoms of epileptic seizures, including uncontrollable shaking or loss of awareness of surroundings. There are many other disorders with symptoms that mimic those of epilepsy, thus accurate diagnosis is essential for effective treatment. This book is a comprehensive guide to the diagnosis of disorders that may mimic epilepsy. Divided into 22 sections, each chapter covers a different epilepsy imitator presented as an analytical discourse. A number of case studies are also included. The book concludes with discussion on the use of EEG (a test that detects electrical activity in the brain using small, metal discs (electrodes) attached to the scalp) and its potential pitfalls. Also included, is a chapter dedicated to Sir William Gowers, a British neurologist at the forefront of the diagnosis and treatment of epilepsy and other neurological disorders (1845-1915). The text is further enhanced by clinical images and figures. Key points Comprehensive guide to diagnosis of MIMICS of epilepsy Covers many different imitators presented as analytical discourse Includes discussion on use and potential pitfalls of diagnostic EEG Features clinical images and figures as well as a selection of case studies

Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. International list of contributors including the leading workers in the field. Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.

The clinical management of patients with epilepsy and the associated medical literature are rapidly evolving. Evidence-based Management of Epilepsy differs from other epilepsy textbooks by focusing specifically on topics where the available evidence is sufficiently well developed to be synthesized into straightforward summaries of proven therapies. When evidence is missing or there is doubt, controversy or ambiguity, the distinguished authors offer treatment recommendations based on practice guidelines or consensus statements that span the gaps in evidence while pointing to those areas where further research is needed. The initial chapters cover critically important aspects of antiepileptic drugs (AEDs) and surgical treatment such as when to start and stop AEDs, how to monitor their effectiveness, special considerations in women who become pregnant, and when to consider surgery to alleviate seizures. The following chapters cover the therapy of seizures when they develop after traumatic brain injury or stroke, and the treatment of concomitant depression and anxiety in patients with epilepsy. The final chapters discuss emerging topics in epilepsy: the treatment of the postictal state, technologies to predict and detect seizures, strategies for closing the treatment gap and sudden unexpected death in epilepsy. The contributors are renowned experts in their fields who successfully and succinctly present state-of-the-art reviews based on the medical evidence designed to help the clinician be as best informed as possible in the care of patients with epilepsy.