A major compilation & presentation of amino & DNA sequences produced under the direction of Dr. Elvin A. Kabat, who received a National Medal of Science in 1991, for his "seminal contributions in the field of immunology". Contains new & expanded sections on T-cell reactors, §2-microglobulins, major histocompatibiltiy antigens, complement, thymopoietin, integrins, & post-gamma globulin. Covers 9,000 sequences, plus 3 indices: index of proteins, index of antibody specificities & index of references. Best seller!!

Tabulation and analysis of amino acid and nucleic acid sequences of precursors, v-regions, c-regions, j-chain, T-cell receptors for antigen, T-cell surface antigens, l-microglobulins, major histocompatibility antigens, thy-1, complement, c-reactive protein, thymopoietin, integrins, post-gamma globulin, -macroglobulins, and other related proteins.

The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these have become indispensable reagents in biomedical research, while others were developed for novel therapeutic applications. The attractiveness of an- bodies in this regard is obvious—high target specificity, adaptability to a wide range of disease states, and the potential ability to direct the host’s immune s- tem for a therapeutic response. The initial excitement in finding Paul Ehrlich’s “magic bullet,” however, was met with widespread disappointment when it was demonstrated that murine antibodies frequently elicit the human anti-murine an- body (HAMA) response, thus rendering them ineffective and potentially unsafe in humans. Despite this setback, advances in recombinant DNA techniques over the last 15–20 years have empowered the engineering of recombinant antibodies with desired characteristics, including properties to avoid HAMA. The ability to p- duce bulk quantities of recombinant proteins from bacterial fermentation also fueled the design of numerous creative antibody constructs. To date, the United States Food and Drug Administration has approved more than 10 recombinant antibodies for human use, and hundreds more are in the development pipeline. The recent explosion in genomic and proteomic information appears ready to deliver many more disease targets amenable to antibody-based therapy.

Advances in Immunology

Immunology is the study of the body's protection from foreign macromolecules or invading organisms and the responses to them. These invaders include viruses, bacteria, protozoa or even larger parasites. In addition, immune responses are developed against our own proteins (and other molecules) in autoimmunity and against our own aberrant cells in tumour immunity. The first line of defense against foreign organisms are barrier tissues such as the skin that stop the entry of organism into our bodies. A second line of defense is the specific or adaptive immune system which may take days to respond to a primary invasion (that is infection by an organism that has not hitherto been seen). This new book brings together new research spanning the globe dealing with this extremely important subject.

This publication is based on a Symposium that has been held in Clearwater, Florida on February 19-21, 1986, on antibodies, their structure, synthesis, function, and clinical applicability in disease. Organization of this symposium by the University of South Florida College of Medicine was prompted by the unparalleled current expansion of information on these topics in general, and in the field of antibody diver sity, in particular. The issues that surround the last named dimension of this field, began to surface in the late 1950's with the first conclusive genetic studies having been answered, and a new set of concepts has been de fined. As we see it from the material presented in this volume, now new and different questions are being raised and answered by studies in progress, and it may be expected that there will be other questions that will be with us for a considerably longer time. We believe that the symposium brought together many prominent investi gators with different backgrounds and training experiences such as immunolo gists, microbiologists, biochemists, molecular biologists, and clinical sci entists, thus providing an excellent example of the interdisciplinary value of modern immunology and modern biomedical science in general. We believe, therefore, that bringing these complex topics to a wide audience of bio medical scientists through this symposium as well as this volume is of value to the scientific and to the medical community.

Reperfusion Injury: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Reperfusion Injury: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Reperfusion Injury: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

This comprehensive collection of recently developed methods for producing new antibody reagents by immunization and recombinant DNA techniques contains ready-to-use protocols that illuminate current areas of research on antibody structure, functions, and applications. The methods can be applied in basic immunological studies involving antibody specificity, catalysis, and evolution, and in the isolation of rare antibodies by phage display technology and the engineering of new antibodies by mutagenesis. They offer insight into new ways of developing clinically useful antibody reagents. Antibody Engineering Protocols constitutes a single-source volume for laboratory investigators who want to minimize extensive literature and methodology searches and to work productively in their fields with reproducible step-by-step protocols.