Trends in Emerging Viral Infections of Swine includes sections on global trade, vaccination regimens against new and emerging viruses, epidemiology and control, as well as significant new outbreaks like the West Nile virus. A contributor to Diseases of Swine, 8th edition, Dr. Zimmerman has selected three additional editors with international expertise.

Obligate intracellular parasitism is the associated with genome reduction, which is the process of reconfiguring the genome through systematic elimination of genetic loci deemed unnecessary. The end-result is an increasing dependence on the host for various factors essential for growth, such as nutrients and a protective intracellular replicative niche. The extreme genome reduction that some of the obligate intracellular bacteria have undergone, while maintaining viability and virulence has revealed the level of adaptability, including a plethora of survival strategies that more often than not functionally converge to modulate similar host cell processes, such as cytoskeletal dynamics, vesicular transport, and pathogen recognition, among others. With the advent of molecular genetic approaches, and in the case of Coxiella, growth in axenic media, the field of obligate intracellular pathogen research has progressed rapidly in the past five years, redefining obligate intracellular parasitism as the field transitions from descriptive to mechanism-based research. An emerging theme is the adaptability and ingenuity of this class of pathogens. Genome reduction prioritizes survival, but because this occurs within a host, there is also the need to maintain virulence. As such, survival strategies become intertwined, and likely inseparable from virulence strategies. The purpose of this Special Topics Issue is to bring together in one volume review articles from experts in the field. This issue will have a broad scope. Articles will describe the current state of knowledge in genetics and genomics, metabolism, cell biology of infection, immune evasion, and vaccine design. Importantly, cutting-edge information will also be discussed in the context of past seminal findings, and future directions of research. Overall, this Special Topics Issue should serve as a valuable reference to colleagues and those new to the field of obligate intracellular pathogens research. We welcome submission of review and mini-review articles on the following topics: • Genome structure • Development of genetic tools • Molecular mechanisms of adhesion, invasion, and other early events in infection • Establishment of the intracellular niche • Niche interactions with organelles • Translocation of effectors • Metabolism and metabolic adaptations • Gene regulation during stress response • Pathogen recognition and immune evasion strategies • Innate and adaptive immunity during infection • Experimental models

Advances in next-generation sequencing technologies (NGS) are revolutionizing the field of food microbiology. Microbial whole genome sequencing (WGS) can provide identification, characterization, and subtyping of pathogens for epidemiological investigations at a level of precision previously not possible. This allows for connections and source attribution to be inferred between related isolates that may be overlooked by traditional techniques. The archiving and global sharing of genome sequences allow for retrospective analysis of virulence genes, antimicrobial resistance markers, mobile genetic elements and other novel genes. The advent of high-throughput 16S rRNA amplicon sequencing, in combination with the advantages offered by massively parallel second-generation sequencing for metagenomics, enable intensive studies on the microbiomes of food products and the impact of foods on the human microbiome. These studies may one day lead to the development of reliable culture-independent methods for food monitoring and surveillance. Similarly, RNA-seq has provided insights into the transcriptomes and hence the behaviour of bacterial pathogens in food, food processing environments, and in interaction with the host at a resolution previously not achieved through the use of microarrays and/or RT-PCR. The vast un-tapped potential applications of NGS along with its rapidly declining costs, give this technology the ability to contribute significantly to consumer protection, global trade facilitation, and increased food safety and security. Despite the rapid advances, challenges remain. How will NGS data be incorporated into our existing global food safety infrastructure? How will massive NGS data be stored and shared globally? What bioinformatics solutions will be used to analyse and optimise these large data sets? This Research Topic discusses recent advances in the field of food microbiology made possible through the use of NGS.

**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Veterinary Medicine** Greene's Infectious Diseases of the Dog and Cat, 5th Edition provides a comprehensive, clinically useful reference on the management of infectious diseases caused by viruses, bacteria (including rickettsiae, chlamydiae, mycoplasmas, and spirochetes), fungi, algae, protozoa, parasites, and other atypical agents. Each section guides the reader through diagnostic testing for specific infectious diseases, from specimen collection to laboratory submission to interpretation of results to appropriate treatment measures. Full-color illustrations and hundreds of tables provide convenient access to diagnostic and therapeutic recommendations, along with the appropriate drug dosages for effective treatment and prevention. A fully searchable enhanced eBook version is included with print purchase, allowing access to all of the text and figures on a variety of digital devices. - More than 150 internationally recognized experts contribute chapters on topics in their field of specialty. - Clear and logical organization of chapters provides a solid basis for an approach to diseases caused by specific pathogens, with the first part of the book including sections on diagnostic approaches, treatments (including recommended antimicrobial drug doses), and prevention. - Specific pathogens are addressed in the second part of the book, using a structured approach that includes etiology/epidemiology (relevance to wildlife animal hosts, role of the environment), clinical and laboratory findings, treatment, prevention, and public health implications. - Case examples illustrate principles and highlight how the material can be applied. - More than 800 clinical images, maps, life cycles, and photomicrographs assist with accurate understanding of epidemiology, pathogenesis, diagnosis of disease, and disease prevention. - Visually appealing maps and life-cycle drawings enhance your comprehension and retention of the material. - Convenient drug dosage tables in each chapter provide complete prescribing information; chapters on antimicrobial drugs in the first part of the book summarize pharmacokinetics, indications, contraindications, handling and administration guidelines; and dosage recommendations are made for antivirals, antibacterials, antifungals, antiprotozoals, and antiparasitic drugs. The book emphasizes approaches to optimize antimicrobial stewardship. - Clinical Problems section helps you understand what infectious diseases should be considered in animals seen with clinical signs relating to different organ systems. - Suggested readings and references are listed in each chapter, facilitating further research and study. - Fully searchable enhanced eBook version is included with print purchase, allowing access to all of the text and figures on a variety of digital devices.