Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.

Explores the scientific discoveries that led to an understanding of the genetic basis of the disease, explaining how a single mutation in hemoglobin multiplies into the many symptoms of sickle cell disease. This book describes treatments that help an individual manage sickle cell disease symptoms.

Providing the answers for a range of adult and paediatric conditions, this text summarises the available tests for most diseases, explaining what the results mean, and discussing differential diagnoses. It also includes additional tests based on molecular biology.

Since the first case of sickle cell disease was described in 1910, several efforts have been made to improve its management. However, it remains the leading scourge of our times, with a high level of morbidity and mortality in Sub-Saharan Africa, the Middle East and India. There have been few efforts by academia in developing countries towards contributing to in-depth knowledge of sickle cell disease. This volume rectifies this by providing a comprehensive review of sickle cell disease from a multidisciplinary point of view. Bringing together a number of experts in the field, the text highlights details of what is known and areas in which future work and advances are needed. The contributions contain comprehensive information on all aspects of the disease, and provides a solid foundation for future studies.

Sickle cell disease (SCD) is a genetic condition that affects approximately 100,000 people in the United States and millions more globally. Individuals with SCD endure the psychological and physiological toll of repetitive pain as well as side effects from the pain treatments they undergo. Some adults with SCD report reluctance to use health care services, unless as a last resort, due to the racism and discrimination they face in the health care system. Additionally, many aspects of SCD are inadequately studied, understood, and addressed. Addressing Sickle Cell Disease examines the epidemiology, health outcomes, genetic implications, and societal factors associated with SCD and sickle cell trait (SCT). This report explores the current guidelines and best practices for the care of patients with SCD and recommends priorities for programs, policies, and research. It also discusses limitations and opportunities for developing national SCD patient registries and surveillance systems, barriers in the healthcare sector associated with SCD and SCT, and the role of patient advocacy and community engagement groups.

Offers a good introduction to the study of diseasees. Each major entry includes information on the causes, signs and symptoms, diagnosis and treatments of various diseases.

Disorders of Hemoglobin stands tall as the definitive work on the genetics, pathophysiology, and clinical management of hemoglobinopathies and thalassemia. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the world authorities on the science and clinical management of these disorders and created the authoritative textbook for researchers and clinicians alike.Authors describe the scientific basis of clinical features and provide clinicians with a clear background of disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference on hemoglobinopathies for hematologists, pediatricians, clinical investigators, and geneticists worldwide.

Following its highly successful and well-respected first edition, this thoroughly revised edition offers much more! Edited and authored by leading authorities in hematology, this scientific reference textbook now comes with a CD-ROM. Additional features include some of the more salient standard and current therapeutics and an easily accessible appendix that provides great reference. The CD-ROM contains 100 of the most critical illustrations from the text—great for quick consultation from your computer.

Completely revised and updated, this broad yet comprehensive edition contains twenty-nine chapters on nursing issues and clinical practice. Topics cover practice and process, documentation, legal issues, health promotion, physical assessment, I.V. therapy, surgical care, and more. Disorders are organized by body system and feature an overview of anatomy and physiology, assessment, diagnostic tests, medication, treatment, and home care, with coverage of care for maternal-neonatal, pediatric, geriatric, emergency, and psychiatric patients. Added features include grabbing nursing procedure graphics, complementary therapies, clinical pathways, and cultural information. Over 1,000 illustrations, charts, and graphs enhance the text, with a new appendix relating Internet sites for nurses.