The revised edition of this bestselling textbook provides latest and detailed account of vital topics in biology, namely, Cell Biology, Genetics, Molecular Biology, Evolution and Ecology . The treatment is very exhaustive as the book devotes exclusive parts to each topic, yet in a simple, lucid and concise manner. Simplified and well labelled diagrams and pictures make the subject interesting and easy to understand. It is developed for students of B.Sc. Pass and Honours courses, primarily. However, it is equally useful for students of M.Sc. Zoology, Botany and Biosciences. Aspirants of medical entrance and civil services examinations would also find the book extremely useful.

The first broad survey of these two fields, this book deleniates a framework for integrating advances in human genetics into public health practice.

This book presents the latest in decision-making tools, techniques, and solutions for policy makers to utilize in overcoming the challenges faced by healthcare systems. With contributions from experts world-wide, an array of healthcare management models, techniques, and integrative solutions are presented, drawing on econometric, system dynamics, and agent-based models as well as state-of-the-art empirical studies. As total healthcare spending (both total expenditures on health as a percentage of GDP and average spending on per capita) increases across most of the world’s economies, healthcare systems continue to face challenges in terms of cost, quality, and access, as a result of its fragmented nature. Consequently, healthcare managers and policy makers require innovative integrative approaches and solutions to better manage complex, dynamic healthcare systems. This volume offers researchers and policy makers an insightful and critical review of the state of the art in healthcare modeling, with a particular focus on system dynamics, agent-based models, and modern empirical studies. It will be of interest to those in the fields of health, business management, and information systems.

This highly acclaimed textbook is written specifically for students of medicine and related health science subjects. It progresses from a review of general pathology principles and disease mechanisms through detailed discussions of the pathologic entities associated with each organ system. Nearly 700 full-color photographs and pathology slides bring the content to life. The fifth edition features extensive updates throughout to reflect the latest discoveries in cellular and molecular pathology, and offers a web site that presents self-assessment material and illustrated clinical case studies. Contents perfectly matches needs on medical students. Very clinical approach matches integrated courses. Extensive International Advisory Board validates contents. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers a superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook./a

With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.

This comprehensive introduction to the field of human biology covers all the major areas of the field: genetic variation, variation related to climate, infectious and non-infectious diseases, aging, growth, nutrition, and demography. Written by four expert authors working in close collaboration, this second edition has been thoroughly updated to provide undergraduate and graduate students with two new chapters: one on race and culture and their ties to human biology, and the other a concluding summary chapter highlighting the integration and intersection of the topics covered in the book.

Sports, Society, and Technology: Bodies, Practices, and Knowledge Production addresses the complex entanglements of science, technology, and sporting cultures. The collection explores themes around human and non-human actants, knowledge formations and processes, and the materiality and multiplicity of bodies through an engagement with the interdisciplinary fields of Sport Studies and Science and Technology Studies. Representing a range of methodological, theoretical, and disciplinary approaches, contributors interrogate the social, cultural, political, and historical intersections of an ever-expanding techno-scientific sporting landscape – from true bounce and brain trauma to exercise physiology, metrics, and esports, and from feminist technoscience, whey protein, and epigenetics to sickle cell screening and testosterone regulation.

Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress. Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders. The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens. Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.