Skin Diseases After Organ Transplantation

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Organ transplantation has been successfully performed over the last 35 years and the number of organ allograft recipients is steadily increasing. Long-term immunosuppression, necessary for good graft function, inevitably induces undesired effects (particularly infectious and neoplastic ones) among which cutaneous ones are very frequent and potentially life-threatening. This book deals with all aspects of cutaneous disorders that may be encountered in the setting of organ transplantation. It reflects the pioneering work performed since long by Dermatologists in Lyon, in collaboration with teams specialised in kidney, heart, lung, liver and pancreas transplantation.

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Genre : Medical
Author : Sylvie Euvrard
Publisher : John Libbey Eurotext
Release : 1998
File : 258 Pages
ISBN-13 : 2742002405


Skin Disease In Organ Transplantation

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Skin disease is a serious long-term problem for the recipients of solid organ transplants. The potent systemic immunosuppression therapy necessary to sustain a life-saving solid organ transplant is associated with many adverse cutaneous effects, including significantly increased rates of cutaneous malignancies, difficult-to-treat cutaneous infections, and cutaneous adverse manifestations of multiple medications. This book is the first scholarly compilation of the knowledge base surrounding the care of solid organ transplant recipients with dermatologic diseases. Supplemented with dozens of full-color photographs, this work brings together decades of knowledge into a cohesive format and establishes transplant dermatology as an important subspecialty within the field of dermatology and transplant medicine. Skin Disease in Organ Transplantation is an outstanding resource for transplant providers and dermatologists to determine the optimal diagnostic and therapeutic approach to the difficult problems of cutaneous disease in organ transplant recipients.

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Genre : Medical
Author : Clark C. Otley
Publisher : Cambridge University Press
Release : 2008-01-21
File : 355 Pages
ISBN-13 : 9780521870672


Skin Cancer After Organ Transplantation

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Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.

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Genre : Medical
Author : Eggert Stockfleth
Publisher : Springer Science & Business Media
Release : 2009-05-05
File : 492 Pages
ISBN-13 : 9780387785745


Dermatology And Solid Organ Transplantation

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This textbook brings together experts in the field of transplant dermatology to review both state of the art and practical knowledge regarding the clinical presentation and management of the various cutaneous diseases seen in patients with solid organ transplant. Practicing dermatologists, trainees, and other health care providers involved in the care of transplant patients can learn the current diagnostic and management options, and how to apply these guidelines and principles in their everyday practice.

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Genre : Medical
Author : Nathalie C. Zeitouni
Publisher : CRC Press
Release : 2021-08-15
File : 395 Pages
ISBN-13 : 9781000415926


Atlas Of Dermatologic Diseases In Solid Organ Transplant Recipients

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BOOK EXCERPT:

The number of solid organ transplant recipients is increasing worldwide every year, which has meant a significant improvement of recipient’s survival and quality of life. To prevent graft rejection, patients require long-term immunosuppression, which is responsible for their increased risk of neoplastic and infectious diseases. This practical and concise atlas presents the most important dermatoses in solid organ transplant recipients. Providing a guide to diagnosis and appropriate therapy, it helps dermatologists, general practitioners and physicians manage the dermatoses found in organ transplant recipients. The first three chapters discuss immunosuppressive regimens and the prevalence of dermatoses, while the other chapters approach the main diseases didactically, providing a large number of illustrations.

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Genre : Medical
Author : Jane Tomimori
Publisher : Springer Nature
Release : 2022-11-14
File : 445 Pages
ISBN-13 : 9783031133350


Skin Diseases In The Immunosuppressed

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In this book, expert dermatologists review state of the art knowledge concerning the clinical presentation and management of cutaneous diseases that develop in immunosuppressed individuals. A major aim is to enable dermatologists to identify the specific immunosuppressant responsible for a specific adverse effect in patients receiving a complex medication regimen in the setting of transplantation. Further, the book will help the dermatologist to distinguish the cutaneous adverse effects of antiviral agents from effects arising directly from advancing HIV disease. Recognition of the cutaneous manifestations of often less common primary immunodeficiencies will also be emphasized. A final goal is to improve patient outcomes by identifying treatment strategies for skin disease arising in the immunosuppressed state. This book will be invaluable for a broad audience, from practicing dermatologists to medical and dermatology residents.​

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Genre : Medical
Author : Oscar R. Colegio
Publisher : Springer
Release : 2018-03-28
File : 213 Pages
ISBN-13 : 9783319687902


Transplant Infections

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Transplant Infections is a practical, clinically focused reference covering the common and more unusual bacterial, viral, and fungal infections affecting patients who have received stem cell or solid organ transplants. It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. Highlights of the Third Edition include a chapter on new immunosuppressive agents and expanded coverage of tropical infections and West Nile virus.

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Genre : Medical
Author : Raleigh A. Bowden
Publisher : Lippincott Williams & Wilkins
Release : 2012-03-28
File : 800 Pages
ISBN-13 : 9781451148091


Transplantation Dermatology

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Patients undergoing solid organ and hematopoietic stem cell transplantation frequently develop skin diseases that can be challenging to themselves and their doctors.In the first part of this volume, prevalent epidemiological, clinical and histological skin problems of solid organ recipients are discussed. Pre- and posttransplant management as well as follow-up programs are presented focusing on European and Swiss guidelines. A special chapter is dedicated to immunosuppressive drugs considering current standards, and new and upcoming medication. The second part starts with a summary of historical aspects of hematopoietic stem cell transplantation, and proceeds with a description of skin manifestations of graft-versus-host disease and their therapy. Covered are early, late and very late periods after transplantation with a focus on recent consensus classification and treatment aspects of chronic graft-versus-host disease. The publication ends with a comprehensive review and practical guidance on photoprotection in transplant recipients.This book covers all the important dermatological aspects that should be considered in diagnosis and treatment of recipients of solid organ and hematopoietic stem cell transplants. It is intended as a guide for dermatologists, nephrologists, hemato-oncologists and all specialists involved in the field of transplantation.

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Genre : Medical
Author : P. Häusermann
Publisher : Karger Medical and Scientific Publishers
Release : 2012-02-29
File : 212 Pages
ISBN-13 : 9783805598569


Kidney Transplantation Principles And Practice E Book

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With meticulous updates throughout, Kidney Transplantation remains your definitive medical resource for state-of-the-art answers on every aspect of renal transplantation. A multidisciplinary approach from internationally renowned nephrologists from around the world offers practice-applicable guidance for all members of the transplant team. With coverage encompassing applied science, surgical techniques, immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, both in adults and children, you’ll have the balanced information you need to achieve the best possible outcomes. Visualize key concepts and discern nuances of renal transplantation techniques through more than 335 superb illustrations.

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Genre : Medical
Author : Stuart J. Knechtle
Publisher : Elsevier Health Sciences
Release : 2013-10-24
File : 777 Pages
ISBN-13 : 9781455774050


Primary Care Of The Solid Organ Transplant Recipient

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BOOK EXCERPT:

Solid organ transplantation offers a new chance at life to those suffering from failing organs. With these successes, however, comes the everyday management that is required to maintain health. The field of solid organ transplantation has become a part of medicine that generalists should be familiar with, as recipients are living longer and frequently returning to primary care for management. While specialists will still need to be involved with the care of solid organ transplant recipients on a life-long basis, many conditions will still need initial and often ongoing care by generalists, including infections, metabolic conditions, psychiatric illnesses, and malignancy. This book focuses on the care of adult solid organ transplant recipients, and is targeted at the level of the primary care provider. It begins with an introduction and overviews of solid organ transplantation and anti-rejection medications. It then delves into organ-specific chapters that provide the primary care provider with an overview of how to take care of patients with the most commonly-transplanted solid organs: kidney, kidney-pancreas, liver, heart, and lung. The final section focuses on specific complications that arise from transplantation including cancer, metabolic conditions, infections, and common presenting syndromes. Preventative health is also discussed, and the book concludes with a chapter on palliative care. Primary Care of the Solid Organ Transplant Recipient is a unique text that provides the reader with organ and complication-specific sections that can be independently read as they relate to the individual physicians and their patients. Written by experts in the field, this text is a valuable resource for primary care providers, medical students, residents and anyone involved in the care of solid organ transplant recipients.

Product Details :

Genre : Medical
Author : Christopher J. Wong
Publisher : Springer Nature
Release : 2020-09-02
File : 333 Pages
ISBN-13 : 9783030506292