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BOOK EXCERPT:
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Product Details :
Genre |
: Medical |
Author |
: H. Jphn Smith |
Publisher |
: CRC Press |
Release |
: 2005-10-10 |
File |
: 684 Pages |
ISBN-13 |
: 9780203304150 |
eBook Download
BOOK EXCERPT:
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Product Details :
Genre |
: Medical |
Author |
: H. John Smith |
Publisher |
: CRC Press |
Release |
: 1998-05-15 |
File |
: 578 Pages |
ISBN-13 |
: 9057020378 |
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BOOK EXCERPT:
This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
Product Details :
Genre |
: Medical |
Author |
: David A. Williams |
Publisher |
: Lippincott Williams & Wilkins |
Release |
: 2002 |
File |
: 1136 Pages |
ISBN-13 |
: 9780683307375 |
eBook Download
BOOK EXCERPT:
The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at thePoint.
Product Details :
Genre |
: Medical |
Author |
: Thomas L. Lemke |
Publisher |
: Lippincott Williams & Wilkins |
Release |
: 2008 |
File |
: 1406 Pages |
ISBN-13 |
: 0781768799 |
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BOOK EXCERPT:
While drug therapies developed in the last 50 years have markedly improved the management of some types of cancers, treatment outcomes, and drug side-effects for the most common types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells.
Product Details :
Genre |
: Medical |
Author |
: David E. Thurston |
Publisher |
: CRC Press |
Release |
: 2006-11-22 |
File |
: 312 Pages |
ISBN-13 |
: 9781420008906 |
eBook Download
BOOK EXCERPT:
Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.
Product Details :
Genre |
: Medical |
Author |
: János Fischer |
Publisher |
: John Wiley & Sons |
Release |
: 2012-10-15 |
File |
: 393 Pages |
ISBN-13 |
: 9783527651108 |
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BOOK EXCERPT:
Product Details :
Genre |
: Drugs |
Author |
: H. J. Smith |
Publisher |
: |
Release |
: 1988 |
File |
: 368 Pages |
ISBN-13 |
: UOM:39015019473084 |
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BOOK EXCERPT:
Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
Product Details :
Genre |
: Medical |
Author |
: H. J. Smith |
Publisher |
: Elsevier |
Release |
: 2016-06-14 |
File |
: 307 Pages |
ISBN-13 |
: 9781483183503 |
eBook Download
BOOK EXCERPT:
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Product Details :
Genre |
: Medical |
Author |
: H. John Smith |
Publisher |
: CRC Press |
Release |
: 2004-04-28 |
File |
: 697 Pages |
ISBN-13 |
: 9780203496671 |
eBook Download
BOOK EXCERPT:
The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
Product Details :
Genre |
: Drugs |
Author |
: S. N. Pandeya |
Publisher |
: New Age International |
Release |
: 1997 |
File |
: 228 Pages |
ISBN-13 |
: 8122409431 |