This book constitutes the strictly refereed post-workshop proceedings of the International Workshop on Requirements Targeting Software and Systems Engineering, RTSE '97, held in Bernried, Germany in October 1997. The 15 revised full papers presented in the book were carefully revised and reviewed for inclusion in the book. Among the authors are internationally leading researchers. The book is divided in sections on foundations of software engineering, methodology, evaluation and case studies, and tool support and prototyping.

This book provides a unique overview of different approaches to developing software that is flexible, adaptable and easy to maintain and reuse. It covers the most recent advances in software architecture research. In addition, it provides the reader with scalable solutions for engineering and reengineering business processes, including architectural components for business applications, framework design for Internet distributed business applications, and architectural standards for enterprise systems.

This book is a comprehensive, step-by-step guide to software engineering.This book provides an introduction to software engineering for students in undergraduate and post graduate programs in computers.

The trusted handbook—now in a new edition This newly revised handbook presents a multifaceted view of systems engineering from process and systems management perspectives. It begins with a comprehensive introduction to the subject and provides a brief overview of the thirty-four chapters that follow. This introductory chapter is intended to serve as a "field guide" that indicates why, when, and how to use the material that follows in the handbook. Topical coverage includes: systems engineering life cycles and management; risk management; discovering system requirements; configuration management; cost management; total quality management; reliability, maintainability, and availability; concurrent engineering; standards in systems engineering; system architectures; systems design; systems integration; systematic measurements; human supervisory control; managing organizational and individual decision-making; systems reengineering; project planning; human systems integration; information technology and knowledge management; and more. The handbook is written and edited for systems engineers in industry and government, and to serve as a university reference handbook in systems engineering and management courses. By focusing on systems engineering processes and systems management, the editors have produced a long-lasting handbook that will make a difference in the design of systems of all types that are large in scale and/or scope.

Software engineering research can trace its roots to a few highly influential individuals. Among that select group is Leon J. Osterweil, who has been a major force in driving software engineering from its infancy to its modern reality. For more than three decades, Prof. Osterweil's work has fundamentally defined or significantly impacted major directions in software analysis, development tools and environments, and software process--all critical parts of software engineering as it is practiced today. His exceptional contributions to the field have been recognized with numerous awards and honors through his career, including the ACM SIGSOFT Outstanding Research Award, in recognition of his extensive and sustained research impact, and the ACM SIGSOFT Influential Educator Award, in recognition of his career-long achievements as an educator and mentor. In honor of Prof. Osterweil's profound accomplishments, this book was prepared for a special honorary event held during the 2011 International Conference on Software Engineering (ICSE). It contains some of his most important published works to date, together with several new articles written by leading authorities in the field, exploring the broad impact of his work in the past and how it will further impact software engineering research in the future. These papers, part of the core software engineering legacy and now available in one commented volume for the first time, are grouped into three sections: flow analysis for software dependability, the software lifecycle, and software process.

This book discusses the problems and challenges in the interdisciplinary research field of self-adaptive software systems. Modern society is increasingly filled with software-intensive systems, which are required to operate in more and more dynamic and uncertain environments. These systems must monitor and control their environment while adapting to meet the requirements at runtime. This book provides promising approaches and research methods in software engineering, system engineering, and related fields to address the challenges in engineering the next-generation adaptive software systems. The contents of the book range from design and engineering principles (Chap. 1) to control–theoretic solutions (Chap. 2) and bidirectional transformations (Chap. 3), which can be seen as promising ways to implement the functional requirements of self-adaptive systems. Important quality requirements are also dealt with by these approaches: parallel adaptation for performance (Chap. 4), self-adaptive authorization infrastructure for security (Chap. 5), and self-adaptive risk assessment for self-protection (Chap. 6). Finally, Chap. 7 provides a concrete self-adaptive robotics operating system as a testbed for self-adaptive systems. The book grew out of a series of the Shonan Meetings on this ambitious topic held in 2012, 2013, and 2015. The authors were active participants in the meetings and have brought in interesting points of view. After several years of reflection, they now have been able to crystalize the ideas contained herein and collaboratively pave the way for solving some aspects of the research problems. As a result, the book stands as a milestone to initiate further progress in this promising interdisciplinary research field.

Modernsoftwaresystemsincreasinglyusecommercial-o?-the-shelf(COTS)so- ware products as building blocks. In some cases, major software systems are assembled with virtually no custom code in the system. The use of COTS software products as components o?ers the promise of rapid delivery to end users, shared development costs with other customers, and an opportunity for expanding mission or business capabilities and performance as improvements are made in the commercial marketplace. Few organizations today can a?ord the resources and time to replicate market-tested capabilities. Yet, the promise of COTS products is too often not realized in practice. There have been more failures than successes in using COTS software products. The research and software practitioner communities have been working with COTS-based software systems for a number of years. There is now su?cient documented experience in the community to collect, analyze, and disseminate success stories, common failings, lessons-learned, and research advances. The mounting experience shows that the e?ective use of COTS software products in major software systems demands new skills, knowledge, and abilities, changed roles and responsibilities, and di?erent techniques and processes. The International Conference on COTS-Based Software Systems (ICCBSS) focuses on the challenges of building and maintaining systems that incorporate COTSsoftwareproducts.Theconferencesponsors,theNationalResearchCo- cil Canada, the Software Engineering Institute, and the University of Southern California Center for Software Engineering, aim to bring together managers, - velopers, maintainers, and researchers to share their expertise and experience.

As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have made bioequivalence testing more complex. The second edition of Handbook of Bioequivalence Testing has been completely updated to include the most current information available, including new findings in drug delivery and dosage form design and revised worldwide regulatory requirements. New topics include: A historical perspective on generic pharmaceuticals New guidelines governing submissions related to bioequivalency studies, along with therapeutic code classifications Models of noninferiority Biosimilarity of large molecule drugs Bioequivalence of complementary and alternate medicines Bioequivalence of biosimilar therapeutic proteins and monoclonal antibodies New FDA guidelines for bioanalytical method validation Outsourcing and monitoring of bioequivalence studies The cost of generic drugs is rising much faster than in the past, partly because of the increased costs required for approval—including those for bioequivalence testing. There is a dire need to re-examine the science behind this type of testing to reduce the burden of development costs—allowing companies to develop generic drugs faster and at a lower expense. The final chapter explores the future of bioequivalence testing and proposes radical changes in the process of biowaivers. It suggests how the cost of demonstrating bioequivalence can be reduced through intensive analytical investigation and proposes that regulatory agencies reduce the need for bioequivalence studies in humans. Backed by science and updated with the latest research, this book is destined to spark continued debate on the efficacy of the current bioequivalence testing paradigm.