Dieser Band behandelt eine Reihe statistischer Themen, die bei der Analyse biologischer und medizinischer Daten allgemein Anwendung finden. Diese 2. Auflage wurde komplett überarbeitet, aktualisiert und erweitert. Einige Kapitel sind neu hinzugekommen, u.a. zur multiplen linearen Regression in der biomedizinischen Forschung. Der Stoff ist so gegliedert, dass der Leser den Text unabhängig von der jeweiligen statistischen Methode leicht nach Problemstellungen durchsuchen kann. Mit zahlreichen durchgearbeiteten Beispielen, die detaillierte Lösungsangaben zu Problemen aus der Praxis liefern.

Praise for the Third Edition “. . . an easy-to read introduction to survival analysis which covers the major concepts and techniques of the subject.” —Statistics in Medical Research Updated and expanded to reflect the latest developments, Statistical Methods for Survival Data Analysis, Fourth Edition continues to deliver a comprehensive introduction to the most commonly-used methods for analyzing survival data. Authored by a uniquely well-qualified author team, the Fourth Edition is a critically acclaimed guide to statistical methods with applications in clinical trials, epidemiology, areas of business, and the social sciences. The book features many real-world examples to illustrate applications within these various fields, although special consideration is given to the study of survival data in biomedical sciences. Emphasizing the latest research and providing the most up-to-date information regarding software applications in the field, Statistical Methods for Survival Data Analysis, Fourth Edition also includes: Marginal and random effect models for analyzing correlated censored or uncensored data Multiple types of two-sample and K-sample comparison analysis Updated treatment of parametric methods for regression model fitting with a new focus on accelerated failure time models Expanded coverage of the Cox proportional hazards model Exercises at the end of each chapter to deepen knowledge of the presented material Statistical Methods for Survival Data Analysis is an ideal text for upper-undergraduate and graduate-level courses on survival data analysis. The book is also an excellent resource for biomedical investigators, statisticians, and epidemiologists, as well as researchers in every field in which the analysis of survival data plays a role.

Features a practical approach to the analysis of biomedical data via mathematical methods and provides a MATLAB® toolbox for the collection, visualization, and evaluation of experimental and real-life data Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® presents a practical approach to the task that biological scientists face when analyzing data. The primary focus is on the application of mathematical models and scientific computing methods to provide insight into the behavior of biological systems. The author draws upon his experience in academia, industry, and government–sponsored research as well as his expertise in MATLAB to produce a suite of computer programs with applications in epidemiology, machine learning, and biostatistics. These models are derived from real–world data and concerns. Among the topics included are the spread of infectious disease (HIV/AIDS) through a population, statistical pattern recognition methods to determine the presence of disease in a diagnostic sample, and the fundamentals of hypothesis testing. In addition, the author uses his professional experiences to present unique case studies whose analyses provide detailed insights into biological systems and the problems inherent in their examination. The book contains a well-developed and tested set of MATLAB functions that act as a general toolbox for practitioners of quantitative biology and biostatistics. This combination of MATLAB functions and practical tips amplifies the book’s technical merit and value to industry professionals. Through numerous examples and sample code blocks, the book provides readers with illustrations of MATLAB programming. Moreover, the associated toolbox permits readers to engage in the process of data analysis without needing to delve deeply into the mathematical theory. This gives an accessible view of the material for readers with varied backgrounds. As a result, the book provides a streamlined framework for the development of mathematical models, algorithms, and the corresponding computer code. In addition, the book features: Real–world computational procedures that can be readily applied to similar problems without the need for keen mathematical acumen Clear delineation of topics to accelerate access to data analysis Access to a book companion website containing the MATLAB toolbox created for this book, as well as a Solutions Manual with solutions to selected exercises Applied Mathematics for the Analysis of Biomedical Data: Models, Methods, and MATLAB® is an excellent textbook for students in mathematics, biostatistics, the life and social sciences, and quantitative, computational, and mathematical biology. This book is also an ideal reference for industrial scientists, biostatisticians, product development scientists, and practitioners who use mathematical models of biological systems in biomedical research, medical device development, and pharmaceutical submissions.

The second edition of a well-received book that was published 24 years ago and continues to sell to this day, An Introduction to Probability and Statistics is now revised to incorporate new information as well as substantial updates of existing material.

Das für Fachleute und fortgeschrittene Studenten konzipierte Buch beschäftigt sich mit dem Entwurf und der Analyse von Untersuchungen, Studien und Experimenten, bei denen qualitative und kategorische Daten anfallen. - jetzt in dritter Auflage - neue Informationen unter anderem zur logistischen Regression, zur Binomialverteilung, zu Daten von (zufälligen) Stichproben und zu den Delta-Methoden für Multinomialfrequenzen - Buch ist auf seinem Gebiet führend, das bewährte Material der Vorgängerauflagen wurde übernommen

An important role of diagnostic medicine research is to estimate and compare the accuracies of diagnostic tests. This book provides a comprehensive account of statistical methods for design and analysis of diagnostic studies, including sample size calculations, estimation of the accuracy of a diagnostic test, comparison of accuracies of competing diagnostic tests, and regression analysis of diagnostic accuracy data. Discussing recently developed methods for correction of verification bias and imperfect reference bias, methods for analysis of clustered diagnostic accuracy data, and meta-analysis methods, Statistical Methods in Diagnostic Medicine explains: * Common measures of diagnostic accuracy and designs for diagnostic accuracy studies * Methods of estimation and hypothesis testing of the accuracy of diagnostic tests * Meta-analysis * Advanced analytic techniques-including methods for comparing correlated ROC curves in multi-reader studies, correcting verification bias, and correcting when an imperfect gold standard is used Thoroughly detailed with numerous applications and end-of-chapter problems as well as a related FTP site providing FORTRAN program listings, data sets, and instructional hints, Statistical Methods in Diagnostic Medicine is a valuable addition to the literature of the field, serving as a much-needed guide for both clinicians and advanced students.

Nursing Research and Statistics

How to apply statistical methods to survey data--a guide toeffective analysis of health surveys. With large health surveys becoming increasingly available forpublic use, researchers with little experience in survey methodsare often faced with analyzing data from surveys to addressscientific and programmatic questions. This practical book providesstatistical techniques for use in survey analysis, making healthsurveys accessible to statisticians, biostatisticians,epidemiologists, and health researchers. The authors clearlyexplain the theory and methods of survey analysis along withreal-world applications. They draw on their work at the NationalInstitutes of Health as well as up-to-date information from acrossthe literature to present: * The sampling background necessary to understand health surveys. * The application of such techniques as t-tests, linear regression,logistic regression, and survival analysis to survey data. * The use of sample weights in survey data analysis. * Dealing with complications in variance estimation in large healthsurveys. * Applications involving cross-sectional, longitudinal, andmultiple cross-sectional surveys, and the use of surveys to performpopulation- based case-control analyses. * Guidance on the correct use of statistical methods found insoftware packages. * Extensive bibliography.

Nursing Research and Statistics - E-Book

Comparing and contrasting the reality of subjectivity in the workof history's great scientists and the modern Bayesian approach tostatistical analysis Scientists and researchers are taught to analyze their data from anobjective point of view, allowing the data to speak for themselvesrather than assigning them meaning based on expectations oropinions. But scientists have never behaved fully objectively.Throughout history, some of our greatest scientific minds haverelied on intuition, hunches, and personal beliefs to make sense ofempirical data-and these subjective influences have often aided inhumanity's greatest scientific achievements. The authors argue thatsubjectivity has not only played a significant role in theadvancement of science, but that science will advance more rapidlyif the modern methods of Bayesian statistical analysis replace someof the classical twentieth-century methods that have traditionallybeen taught. To accomplish this goal, the authors examine the lives and work ofhistory's great scientists and show that even the most successfulhave sometimes misrepresented findings or been influenced by theirown preconceived notions of religion, metaphysics, and the occult,or the personal beliefs of their mentors. Contrary to popularbelief, our greatest scientific thinkers approached their data witha combination of subjectivity and empiricism, and thus informallyachieved what is more formally accomplished by the modern Bayesianapproach to data analysis. Yet we are still taught that science is purely objective. Thisinnovative book dispels that myth using historical accounts andbiographical sketches of more than a dozen great scientists,including Aristotle, Galileo Galilei, Johannes Kepler, WilliamHarvey, Sir Isaac Newton, Antoine Levoisier, Alexander vonHumboldt, Michael Faraday, Charles Darwin, Louis Pasteur, GregorMendel, Sigmund Freud, Marie Curie, Robert Millikan, AlbertEinstein, Sir Cyril Burt, and Margaret Mead. Also included is adetailed treatment of the modern Bayesian approach to dataanalysis. Up-to-date references to the Bayesian theoretical andapplied literature, as well as reference lists of the primarysources of the principal works of all the scientists discussed,round out this comprehensive treatment of the subject. Readers will benefit from this cogent and enlightening view of thehistory of subjectivity in science and the authors' alternativevision of how the Bayesian approach should be used to further thecause of science and learning well into the twenty-first century.