This book presents selected papers on statistical model development related mainly to the fields of Biostatistics and Bioinformatics. The coverage of the material falls squarely into the following categories: (a) Survival analysis and multivariate survival analysis, (b) Time series and longitudinal data analysis, (c) Statistical model development and (d) Applied statistical modelling. Innovations in statistical modelling are presented throughout each of the four areas, with some intriguing new ideas on hierarchical generalized non-linear models and on frailty models with structural dispersion, just to mention two examples. The contributors include distinguished international statisticians such as Philip Hougaard, John Hinde, Il Do Ha, Roger Payne and Alessandra Durio, among others, as well as promising newcomers. Some of the contributions have come from researchers working in the BIO-SI research programme on Biostatistics and Bioinformatics, centred on the Universities of Limerick and Galway in Ireland and funded by the Science Foundation Ireland under its Mathematics Initiative.

This book is comprised of presentations delivered at the 5th Workshop on Biostatistics and Bioinformatics held in Atlanta on May 5-7, 2017. Featuring twenty-two selected papers from the workshop, this book showcases the most current advances in the field, presenting new methods, theories, and case applications at the frontiers of biostatistics, bioinformatics, and interdisciplinary areas. Biostatistics and bioinformatics have been playing a key role in statistics and other scientific research fields in recent years. The goal of the 5th Workshop on Biostatistics and Bioinformatics was to stimulate research, foster interaction among researchers in field, and offer opportunities for learning and facilitating research collaborations in the era of big data. The resulting volume offers timely insights for researchers, students, and industry practitioners.

This book presents an overview of recent developments in biostatistics and bioinformatics. Written by active researchers in these emerging areas, it is intended to give graduate students and new researchers an idea of where the frontiers of biostatistics and bioinformatics are as well as a forum to learn common techniques in use, so that they can advance the fields via developing new techniques and new results. Extensive references are provided so that researchers can follow the threads to learn more comprehensively what the literature is and to conduct their own research. In particulars, the book covers three important and rapidly advancing topics in biostatistics: analysis of survival and longitudinal data, statistical methods for epidemiology, and bioinformatics.

This book constitutes the thoroughly refereed post-conference proceedings of the 10th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2013, held in Nice, France in June 2013. The 19 revised full papers presented were carefully reviewed and selected from 35 submissions. The papers are organized in topical sections on bioinformatics, biostatistics, knowledge based medicine, and data integration and analysis in omic-science.

This book constitutes the thoroughly refereed post-conference proceedings of the 15th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics., CIBB 2018, held in Caparica, Portugal, in September 2018. The 32 revised full papers were carefully reviewed and selected from 51 submissions. The papers present current trends at the edge of computer and life sciences, the application of computational intelligence to a system and synthetic biology and the consequent impact on innovative medicine were presented. Theoretical and experimental biologists also presented novel challenges and fostered multidisciplinary collaboration aiming to blend theory and practice, where the founding theories of the techniques used for modelling and analyzing biological systems are investigated and used for practical applications and the supporting technologies.

This book constitutes the thoroughly refereed post-proceedings of the 8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011, held in Gargnano del Garda, Italy, in June/July 2011. The 19 papers, presented together with 2 keynote speeches, were carefully reviewed and selected from 24 submissions. The papers are organized in topical sections on statistical learning, genomics, computational intelligence for health at the edge, proteomics, intelligent clinical decision support systems (i-CDSS), bioinformatics, and data clustering.

Provides an accessible foundation to Bayesian analysis using real world models This book aims to present an introduction to Bayesian modelling and computation, by considering real case studies drawn from diverse fields spanning ecology, health, genetics and finance. Each chapter comprises a description of the problem, the corresponding model, the computational method, results and inferences as well as the issues that arise in the implementation of these approaches. Case Studies in Bayesian Statistical Modelling and Analysis: Illustrates how to do Bayesian analysis in a clear and concise manner using real-world problems. Each chapter focuses on a real-world problem and describes the way in which the problem may be analysed using Bayesian methods. Features approaches that can be used in a wide area of application, such as, health, the environment, genetics, information science, medicine, biology, industry and remote sensing. Case Studies in Bayesian Statistical Modelling and Analysis is aimed at statisticians, researchers and practitioners who have some expertise in statistical modelling and analysis, and some understanding of the basics of Bayesian statistics, but little experience in its application. Graduate students of statistics and biostatistics will also find this book beneficial.

The advent of high-speed, affordable computers in the last two decades has given a new boost to the nonparametric way of thinking. Classical nonparametric procedures, such as function smoothing, suddenly lost their abstract flavour as they became practically implementable. In addition, many previously unthinkable possibilities became mainstream; prime examples include the bootstrap and resampling methods, wavelets and nonlinear smoothers, graphical methods, data mining, bioinformatics, as well as the more recent algorithmic approaches such as bagging and boosting. This volume is a collection of short articles - most of which having a review component - describing the state-of-the art of Nonparametric Statistics at the beginning of a new millennium.Key features:• algorithic approaches • wavelets and nonlinear smoothers • graphical methods and data mining • biostatistics and bioinformatics • bagging and boosting • support vector machines • resampling methods

This book constitutes the thoroughly refereed post-conference proceedings of the 13th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2016, held in Stirling, UK, in September 2016. The 19 revised full papers and 6 keynotes abstracts presented were carefully reviewed and selected from 61 submissions. The papers deal with the application of computational intelligence to open problems in bioinformatics, biostatistics, systems and synthetic biology, medicalinformatics, computational approaches to life sciences in general