The development and application of multivariate statistical techniques in process monitoring has gained substantial interest over the past two decades in academia and industry alike. Initially developed for monitoring and fault diagnosis in complex systems, such techniques have been refined and applied in various engineering areas, for example mechanical and manufacturing, chemical, electrical and electronic, and power engineering. The recipe for the tremendous interest in multivariate statistical techniques lies in its simplicity and adaptability for developing monitoring applications. In contrast, competitive model, signal or knowledge based techniques showed their potential only whenever cost-benefit economics have justified the required effort in developing applications. Statistical Monitoring of Complex Multivariate Processes presents recent advances in statistics based process monitoring, explaining how these processes can now be used in areas such as mechanical and manufacturing engineering for example, in addition to the traditional chemical industry. This book: Contains a detailed theoretical background of the component technology. Brings together a large body of work to address the field’s drawbacks, and develops methods for their improvement. Details cross-disciplinary utilization, exemplified by examples in chemical, mechanical and manufacturing engineering. Presents real life industrial applications, outlining deficiencies in the methodology and how to address them. Includes numerous examples, tutorial questions and homework assignments in the form of individual and team-based projects, to enhance the learning experience. Features a supplementary website including Matlab algorithms and data sets. This book provides a timely reference text to the rapidly evolving area of multivariate statistical analysis for academics, advanced level students, and practitioners alike.

Statistical Process Monitoring Using Advanced Data-Driven and Deep Learning Approaches tackles multivariate challenges in process monitoring by merging the advantages of univariate and traditional multivariate techniques to enhance their performance and widen their practical applicability. The book proceeds with merging the desirable properties of shallow learning approaches – such as a one-class support vector machine and k-nearest neighbours and unsupervised deep learning approaches – to develop more sophisticated and efficient monitoring techniques. Finally, the developed approaches are applied to monitor many processes, such as waste-water treatment plants, detection of obstacles in driving environments for autonomous robots and vehicles, robot swarm, chemical processes (continuous stirred tank reactor, plug flow rector, and distillation columns), ozone pollution, road traffic congestion, and solar photovoltaic systems. - Uses a data-driven based approach to fault detection and attribution - Provides an in-depth understanding of fault detection and attribution in complex and multivariate systems - Familiarises you with the most suitable data-driven based techniques including multivariate statistical techniques and deep learning-based methods - Includes case studies and comparison of different methods

The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees. Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight. Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making. • Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees • Illustrates the types of challenging issues Data Monitoring Committees face in practical situations • Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations • Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research • Expands treatment of current journal publications addressing DMC issues Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.

Hospitals monitoring is becoming more complex and is increasing both because staff want their data analysed and because of increasing mandated surveillance. This book provides a suite of functions in R, enabling scientists and data analysts working in infection management and quality improvement departments in hospitals, to analyse their often non-independent data which is frequently in the form of trended, over-dispersed and sometimes auto-correlated time series; this is often difficult to analyse using standard office software. This book provides much-needed guidance on data analysis using R for the growing number of scientists in hospital departments who are responsible for producing reports, and who may have limited statistical expertise. This book explores data analysis using R and is aimed at scientists in hospital departments who are responsible for producing reports, and who are involved in improving safety. Professionals working in the healthcare quality and safety community will also find this book of interest Statistical Methods for Hospital Monitoring with R: Provides functions to perform quality improvement and infection management data analysis. Explores the characteristics of complex systems, such as self-organisation and emergent behaviour, along with their implications for such activities as root-cause analysis and the Pareto principle that seek few key causes of adverse events. Provides a summary of key non-statistical aspects of hospital safety and easy to use functions. Provides R scripts in an accompanying web site enabling analyses to be performed by the reader http://www.wiley.com/go/hospital_monitoring Covers issues that will be of increasing importance in the future, such as, generalised additive models, and complex systems, networks and power laws.

An Introduction to the Fundamentals and History of Control Charts, Applications, and Guidelines for Implementation Introduction to Statistical Process Control examines various types of control charts that are typically used by engineering students and practitioners. This book helps readers develop a better understanding of the history, implementation, and use-cases. Students are presented with varying control chart techniques, information, and roadmaps to ensure their control charts are operating efficiently and producing specification-confirming products. This is the essential text on the theories and applications behind statistical methods and control procedures. This eight-chapter reference breaks information down into digestible sections and covers topics including: ● An introduction to the basics as well as a background of control charts ● Widely used and newly researched attributes of control charts, including guidelines for implementation ● The process capability index for both normal and non-normal distribution via the sampling of multiple dependent states ● An overview of attribute control charts based on memory statistics ● The development of control charts using EQMA statistics For a solid understanding of control methodologies and the basics of quality assurance, Introduction to Statistical Process Control is a definitive reference designed to be read by practitioners and students alike. It is an essential textbook for those who want to explore quality control and systems design.

This book examines recent methods for data-driven fault diagnosis of multimode continuous processes. It formalizes, generalizes, and systematically presents the main concepts, and approaches required to design fault diagnosis methods for multimode continuous processes. The book provides both theoretical and practical tools to help readers address the fault diagnosis problem by drawing data-driven methods from at least three different areas: statistics, unsupervised, and supervised learning.

Zhiwen Chen aims to develop advanced fault detection (FD) methods for the monitoring of industrial processes. With the ever increasing demands on reliability and safety in industrial processes, fault detection has become an important issue. Although the model-based fault detection theory has been well studied in the past decades, its applications are limited to large-scale industrial processes because it is difficult to build accurate models. Furthermore, motivated by the limitations of existing data-driven FD methods, novel canonical correlation analysis (CCA) and projection-based methods are proposed from the perspectives of process input and output data, less engineering effort and wide application scope. For performance evaluation of FD methods, a new index is also developed.

Mass production companies have become obliged to reduce their production costs and sell more products with lower profit margins in order to survive in competitive market conditions. The complexity and automation level of machinery are continuously growing. This development calls for some of the most critical issues that are reliability and dependability of automatic systems. In the future, machines will be monitored remotely, and computer-aided techniques will be employed to detect faults in the future, and also there will be unmanned factories where machines and systems communicate to each other, detect their own faults, and can remotely intercept their faults. The pioneer studies of such systems are fault diagnosis studies. Thus, we hope that this book will contribute to the literature in this regard.

This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code

The development and application of multivariate statistical techniques in process monitoring has gained substantial interest over the past two decades in academia and industry alike. Initially developed for monitoring and fault diagnosis in complex systems, such techniques have been refined and applied in various engineering areas, for example mechanical and manufacturing, chemical, electrical and electronic, and power engineering. The recipe for the tremendous interest in multivariate statistical techniques lies in its simplicity and adaptability for developing monitoring applications. In contrast, competitive model, signal or knowledge based techniques showed their potential only whenever cost-benefit economics have justified the required effort in developing applications. Statistical Monitoring of Complex Multivariate Processes presents recent advances in statistics based process monitoring, explaining how these processes can now be used in areas such as mechanical and manufacturing engineering for example, in addition to the traditional chemical industry. This book: Contains a detailed theoretical background of the component technology. Brings together a large body of work to address the field’s drawbacks, and develops methods for their improvement. Details cross-disciplinary utilization, exemplified by examples in chemical, mechanical and manufacturing engineering. Presents real life industrial applications, outlining deficiencies in the methodology and how to address them. Includes numerous examples, tutorial questions and homework assignments in the form of individual and team-based projects, to enhance the learning experience. Features a supplementary website including Matlab algorithms and data sets. This book provides a timely reference text to the rapidly evolving area of multivariate statistical analysis for academics, advanced level students, and practitioners alike.