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BOOK EXCERPT:
Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
Product Details :
Genre |
: Medical |
Author |
: Shayne C. Gad |
Publisher |
: CRC Press |
Release |
: 2005-07-18 |
File |
: 600 Pages |
ISBN-13 |
: 0849322146 |
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BOOK EXCERPT:
"This Fourth Edition provides tools for the rigorous and critical analysis of experimental data. Assuming only basic mathematical skills, the book provides a complete and exhaustive introduction to the statistical methods available and updates all material to cover current practices. The book also provides three entirely new and up-to-the-minute chapters. One provides the first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies; two others cover Bayesian analysis and data analysis in pharmacology, which discuss analysis of receptor binding assays, safety pharmacology assays, and other standard study types conducted in pharmacology."--Publisher's description.
Product Details :
Genre |
: MATHEMATICS |
Author |
: Shayne C. Gad |
Publisher |
: |
Release |
: 2005 |
File |
: 567 Pages |
ISBN-13 |
: 0367802759 |
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BOOK EXCERPT:
Statistics plays an important role in pharmacology and related subjects such as toxicology and drug discovery and development. Improper statistical tool selection for analyzing the data obtained from studies may result in wrongful interpretation of the performance or safety of drugs. This book communicates statistical tools in simple language. The
Product Details :
Genre |
: Mathematics |
Author |
: Katsumi Kobayashi |
Publisher |
: CRC Press |
Release |
: 2012-10-18 |
File |
: 230 Pages |
ISBN-13 |
: 9781466515406 |
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BOOK EXCERPT:
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Product Details :
Genre |
: |
Author |
: OECD |
Publisher |
: OECD Publishing |
Release |
: 2014-09-03 |
File |
: 156 Pages |
ISBN-13 |
: 9789264221475 |
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BOOK EXCERPT:
This book acquaints students and practitioners in the related fields of pharmaceutical sciences, clinical trials, and evidence-based medicine with the necessary study design concepts and statistical practices to allow them to understand how drug developers plan and evaluate their drug development. Two goals of the book are to make the material accessible to readers with minimal background in research and to be straightforward enough for self-taught purposes. By bringing the topic from the early discovery phase to clinical trials and medical practice, the book provides an indispensable overview of an otherwise confusing and fragmented set of topics. The author’s experience as a respected scientist, teacher of statistics, and one who has worked in the clinical trials arena makes him well suited to write such a treatise.
Product Details :
Genre |
: Mathematics |
Author |
: J. Rick Turner |
Publisher |
: John Wiley & Sons |
Release |
: 2007-07-27 |
File |
: 298 Pages |
ISBN-13 |
: 9780470073735 |
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BOOK EXCERPT:
Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard-particularly in individuals with compromised or limited organ system functions.Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Su
Product Details :
Genre |
: Medical |
Author |
: Shayne C. Gad |
Publisher |
: CRC Press |
Release |
: 2012-04-26 |
File |
: 213 Pages |
ISBN-13 |
: 9781439845684 |
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BOOK EXCERPT:
The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, government officials, and students.
Product Details :
Genre |
: Medical |
Author |
: J. Rick Turner |
Publisher |
: John Wiley & Sons |
Release |
: 2008-11-26 |
File |
: 500 Pages |
ISBN-13 |
: 9780470411285 |
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BOOK EXCERPT:
This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management. A Guide to Practical Toxicology: examines how to evaluate various groups of chemicals—pharmaceuticals, cosmetics, and agrochemicals provides insights on toxicity determination, normality and naturality, prediction, and regulation Two all-new chapters cover: safety pharmacology evaluation of different chemical classes
Product Details :
Genre |
: Medical |
Author |
: David Woolley |
Publisher |
: CRC Press |
Release |
: 2008-09-22 |
File |
: 472 Pages |
ISBN-13 |
: 9781420043150 |
eBook Download
BOOK EXCERPT:
This book serves as a primary text for students of pharmacology, toxicology, and biology, and as a practical handbook to support the daily operations of the toxicology laboratory and researcher. This edition retains the structure of earlier editions, but has been extensively revised to provide both the student and the working toxicologist with the necessary tools for the rigorous and critical design of studies and analysis of experimental data. Assuming only basic mathematical skills as a starting point, Statistics and Experimental Design for Toxicologists provides a thorough and exhaustive introduction to the statistical methods available to and used in the discipline. A worked, practical example from the field is provided for each technique presented. Written from a toxicologist's perspective, this book provides both the methodological tools necessary to analyze experimental toxicology data and the insight to know when to use them.
Product Details :
Genre |
: Mathematics |
Author |
: Shayne C. Gad |
Publisher |
: CRC Press |
Release |
: 1998-08-14 |
File |
: 456 Pages |
ISBN-13 |
: 0849331382 |
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BOOK EXCERPT:
Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences—from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.
Product Details :
Genre |
: Medical |
Author |
: David Woolley |
Publisher |
: CRC Press |
Release |
: 2017-03-16 |
File |
: 528 Pages |
ISBN-13 |
: 9781498709309 |