Sumo is a fresh and funny introduction to the fascinating world of sumo, Japan's national sport. Author David Benjamin peels away the veneer of sumo as a cultural treasure and reveals it as an action-packed sport populated by superb athletes who employ numerous strategies and techniques to overcome their gargantuan opponents. Sumo provides an engaging, witty, behind-the-scenes look at sumo today.

This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Two years after the rebellion in Aryaka, yokozuna Floortje and her beloved Crown Prince Richie are on a goodwill visit to the neighboring Elven Forest Republic. It only feels too familiar to our heroine when another rebellion begins with her at ground zero—this time, one led by the elven chancellor Mickaël who has seized power in the nation. On their own, some puny elves wouldn’t even make her break a sweat—but it turns out they were foolish enough to forge an alliance with the Demon Lord and his army trained in Dark Sumo, allowing them to roam free in elven towns and forests. Floortje and the prince are forced to make an escape for the time being, with their new ferocious opponents hot on their heels. Coming face-to-face on a yin-yang-shaped dohyō with monsters, led by mighty demons and empowered by their unique special abilities, will Floortje’s sumo prevail once more?

DNA damage response (DDR) is a term that includes a variety of highly sophisticated mechanisms that cells have evolved in safeguarding the genome from the deleterious consequences of DNA damage. It is estimated that every single cell receives tens of thousands of DNA lesions per day. Failure of DDR to properly respond to DNA damage leads to stem cell dysfunction, accelerated ageing, various degenerative diseases or cancer. The sole function of DDR is to recognize diverse DNA lesions, signal their presence, activate cell cycle arrest and finally recruit specific DNA repair proteins to fix the DNA damage and thus prevent genomic instability. DDR is composed of hundreds of spatiotemporally regulated and interconnected proteins, which are able to promptly respond to various DNA lesions. So it is not surprising that mutations in genes encoding various DDR proteins cause embryonic lethality, malignancies, neurodegenerative diseases and premature ageing. The importance of DDR for cell survival and genome stability is unquestionable, but how the sophisticated network of hundreds of different DDR proteins is spatiotemporally coordinated is far from being understood. In the last ten years ubiquitin (ubiquitination) and the ubiquitin-relative SUMO (sumoylation) have emerged as essential posttranslational modifications that regulate DDR. Beside a plethora of ubiqutin and sumo E1-activating enzymes, E2-conjugating enzymes, E3-ligases and ubiquitin/sumo proteases involved in ubiquitination and sumoylation, the complexity of ubiqutin and sumo systems is additionally increased by the fact that both ubiquitin and sumo can form a variety of different chains on substrates which govern the substrate fate, such as its interaction with other proteins, changing its enzymatic activity or promoting substrate degradation. The importance of ubiquitin/SUMO systems in the orchestration of DDR is best illustrated in patients with mutations in E3-ubiquitin ligases BRCA1 or RNF168. BRCA1 is essential for proper function of DDR and its mutations lead to triple-negative breast and ovarian cancers. RNF168 is an E3 ubiquitin ligase, which creates the ubiquitin docking platform for recruitment of different DNA damage signalling and repair proteins at sites of DNA lesion, and its mutations cause RIDDLE syndrome characterized by radiosensitivity, immunodeficiency and learning disability. In addition, recently discovered the ubiquitin receptor protein SPRTN is part of the DNA replication machinery and its mutations cause early-onset hepatocellular carcinoma and premature ageing in humans. Despite more than 700 different enzymes directly involved in ubiquitination and sumoylation processes only few of them are known to play a role in DDR. Therefore, we feel that the role of ubiquitin and the ubiquitin-related SUMO in DDR is far from being understood, and that this is the emerging field that will hugely expand in the next decade due to the rapid development of a new generation of technologies, which will allow us a more robust and precise analyses of human genome, transcriptome and proteome. In this Research Topic we provide a comprehensive overview of our current understanding of ubiquitin and SUMO pathways in all aspects of DDR, from DNA replication to different DNA repair pathways, and demonstrate how alterations in these pathways cause genomic instability that is linked to degenerative diseases, cancer and pathological ageing.

"One of the finest compact books on sumo today."—Sumo World Completely updated by the well known sumo authority David Shapiro, Sumo: A Pocket Guide describes the history, rules, rituals and techniques of sumo, the wrestlers' training and even their diets. Covering such topics as "life in the stables," "psychological warfare," and the "spoils of victory,” this compact sumo guide brings to life this cultural pastime that is so much more than a sport. This volume also includes a list of stables and some of the best chanko–nabe restaurants in Tokyo. Shapiro brings to the updated edition many years of Japanese language, sumo research, and coverage. The result is a handy, up–to–date, and authoritative guide to sumo that provides everything one needs to understand, appreciate, and enjoy this fascinating sport.

When it comes to relationships, reality rules. We'd all like to think of ourselves as everyone's best friend, but what's the truth? Are you a hero or a zero to other people? Do you see yourself as others really see you? Do you need to make a fresh deposit into your relationship account before you go overdrawn? S.U.M.O. Your Relationships will help you manage, maintain, grow and move on, in your key relationships with others and yourself. At some point in your life you are going to have to deal with difficult relationships, whether it's with a colleague, parent, friend or partner. Isn't it time you did a stock take of your relationships and started making the best of them? S.U.M.O. Your Relationships has pit stops, pearls of wisdom and all the humour and inspiration you need to make the key changes in your life. You will discover the seven S.U.M.O. realities followed by seven insights to help light the way to a brighter future. PRAISE FOR S.U.M.O. YOUR RELATIONSHIPS "This book is full of wisdom, common sense and practical ideas on improving relationships. An essential read." —ALLAN PEASE, Co-author of THE DEFINITIVE BOOK OF BODY LANGUAGE and WHY MEN DON'T LISTEN AND WOMEN CAN'T READ MAPS

This lighthearted guide to Japanese sumo is a great introduction to the sport for westerners. Author J.A. Sargeant, sports editor for the English-language, Asahi Evening News, realized that there were many foreigners who would enjoy Sumo more if they knew more of the essential facts about it. Utilizing his knowledge and first-hand information on the sport, he produced this sumo book to meet this need. Written in the humorous, easy-to-read fashion with which the many readers of his sports column will be pleasantly familiar. Mr. Sargeant has also given us a picture of the excitement of the sport, as well as technical aspects that are apt to escape the uninitiated eye.

When Floortje is reincarnated into the world of an otome game, things immediately go wrong. Her fiancé, Prince Jonas, breaks off their engagement, and the supposed protagonist, the Saint of Light Jaromíra, makes Floortje out to be the villainess. Little do they know, however, that Floortje was a sumo wrestler in her past life—and she won’t let these weaklings stand in her way! After rescuing the cat-eared Prince Richie from the castle’s dungeon, Floortje embarks on a journey with an ever-growing sumo stable to save the kingdom from the grips of the real villains, Prince Jonas and Saint Jaromíra. With the spirit of sumo—her most trustworthy ally—to guide her, she’s ready for a smackdown! But why was she reincarnated into an otome game, and how did its protagonist turn evil in the first place?

This is the long awaited second-edition of Paul McGee’s international bestselling personal development heavyweight S.U.M.O. Weighing in with humour, insight, practical tips and personal anecdotes, it’s a thought provoking – and possibly life–changing – read. S.U.M.O. has helped tens of thousands of people fulfil their potential, seize opportunities, succeed at work and respond to adverse situations with a positive attitude. Now comprehensively expanded and even more interactive, the 2nd edition, will help S.U.M.O. fans – and S.U.M.O. virgins – get even more out of this popular, straight-talking guide. S.U.M.O. stands for Shut Up, Move On. It's a phrase to say to ourselves (and sometimes others) when we are acting or thinking in a way that is hindering our ability to succeed. It doesn't necessarily mean 'get over it' or 'pull yourself together' (although there may be occasions when both responses are necessary). 'Shut Up' means stop what you're doing, take time out to reflect, let go of baggage and beliefs that hinder your potential. 'Move On' means tomorrow can be different from today, look for new possibilities, don't just think about it, take action. There are six S.U.M.O. principles that are designed to help you create and enjoy a brilliant life. If you are wrestling with life's challenges, these principles will help you do so more successfully. A brand new principle: E+R=O – Event + Response = Outcome. It's not just what happens to you but how you respond to it that shapes your life – you do have control. Change Your T–Shirt – take responsibility for your own life and don't be a victim. Develop Fruity Thinking – change your thinking and change your results. Hippo Time is OK – understand how setbacks affect you and how to recover from them. Remember the Beachball – increase your understanding and awareness of other people's world. Learn Latin – change comes through action not intention. Overcome the tendency to put things off. Ditch Doris Day – create your own future rather than leave it to chance. Forget the attitude 'que sera, sera, whatever will be, will be.' 'A superb book' Allan and Barbara Pease, bestselling authors of Why Men Don't Listen & Women Can't Read Maps 'The S.U.M.O. approach is powerful, simple and effective. Anyone who reads it is sure to look at themselves and the world differently as a result' Octavius black and Sebastian bailey, co-founders of The Mind Gym

* A much-needed clearinghouse for information on amateur and educational robotics, containing over 2,500 listings of robot suppliers, including mail order and local area businesses * Contains resources for both common and hard-to-find parts and supplies * Features dozens of "sidebars" to clarify essential robotics technologies * Provides original articles on various robot-building topics