This book presents novel in interesting find by multiple accomplished investigators in breast cancer. These chapters elucidate new mechanisms of breast cancer cell death as well as discuss new pathways for therapeutic targeting.

This book provides comprehensive coverage on current trends in marine omics of various relevant topics such as genomics, lipidomics, proteomics, foodomics, transcriptomics, metabolomics, nutrigenomics, pharmacogenomics and toxicogenomics as related to and applied to marine biotechnology, molecular biology, marine biology, marine microbiology, environmental biotechnology, environmental science, aquaculture, pharmaceutical science and bioprocess engineering.

Targeted cancer metabolic pathway anti-cancer drugs achieved great success in malignant cancer treatment, however, inevitably the effect of almost all these drugs is compromised by the development of resistance. Given that recent evidence shows cancer cell metabolic reprogramming occurs after drug treatment, probably, there is a strong relationship between a specific target and particular metabolic pathway remodeling. Understanding the hidden fact and mechanisms under cell metabolism modulated by specific drug targets (in particular those related to precision medicine) may lead to the development of new therapeutic strategies to overcome drug resistance.

Triple negative breast cancers (TNBC) are a biologically aggressiveform of breast cancer and constitute approximately 10-15% of all breast cancerpatients. Distant metastasis, lack of clinically targeted therapies andprognostic markers, makes the disease difficult to treat. Till now not muchwork has been carried out on this deadly disease. This book provides an overview of TNBC etiology, its treatmentstrategies and prognostic markers to identify the outcome of standard therapies.Signalling pathways namely cell proliferation, angiogenesis, invasion andmetastasis, apoptosis, autophagy and others involved in complicating thedisease have been described in the chapters to convey an understanding aboutthe disease mechanisms. All the possible drugs either in pre-clinical orclinical stages have also been mentioned with data that depicts their efficiencyin targeting altered genes. The book also introduces the reader to herbalmedicine exhibiting high potency to target TNBC, their synthetic analogs usedduring chemotherapy and their ability to fight against chemoresistance. Theconcept of phytonanotechnology has also been discussed. The book helps createawareness among a broad range of readers about TNBC. It points to prioritizingthe upgradation of health care facilities and re-designing future treatmentstrategies to provide maximum benefit to breast cancer patients.

Targetting Signaling Pathways in Solid tumour Part B, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the latest information on cancer research - Offers outstanding and original reviews on a range of cancer research topics - Serves as an indispensable reference for researchers and students alike

Master the basic principles of pharmacology and safe medication administration with Clayton’s Basic Pharmacology for Nurses, 18th Edition. Known for its impeccably accurate and up-to-date drug content, this best-selling text consistently underscores medication safety as it guides you in applying pharmacology information to the nursing process. Introductory units acquaint you with the basic principles of pharmacology and medication administration, while subsequent body-system units prepare you to apply the nursing process to every major disorder. Clear guidelines cover safe drug handling, the types of drugs used for disorders or to affect body systems, injection and enteral administration, and patient education. From a respected author team, this full-color text also provides an excellent review for the pharmacology questions on the NCLEX® examination. Medication safety is underscored through Medication Safety Alerts and Clinical Pitfall boxes, as well as Do-Not-Confuse and High Alert icons. Unit on medication administration clearly and visually outlines assessment, techniques, procedures, and documentation for safe administration of percutaneous, enteral, and parenteral drugs. Application of the nursing process offers an overview of general principles of nursing care for each disorder as well as specific nursing considerations for the drug treatment. Lifespan Considerations boxes for children and for older adults draw attention to information that would be especially important when giving a specific drug to patients of those age groups. Drug tables clearly outline generic and brand names, availability, and dosage ranges for key medications for each disorder. Clinical Goldmine boxes focus on best practices in the clinical setting. Get Ready for the NCLEX® Examination! section at the end of each chapter covers key points from the chapter as well as review questions to help prepare for course assessments and the NCLEX Examination. Video clips on medication administration procedures provide a visual reference for safe medication administration. Key terms with phonetic pronunciations and text page references are listed at the beginning of each chapter. NEW! Chapter on Neurodegenerative Disorders covers drugs for dementia and Alzheimer’s Disease. NEW! Updated guidelines on diabetes, heart failure, asthma, COPD, and cancer ensure readers are versed in the latest treatment protocols. NEW! Accurate and up-to-date coverage includes the most recent FDA approvals, withdrawals, therapeutic uses, and content on cultural considerations related to each drug class.