The Host of Martha Stewart's "Living Today" on Martha Stewart Living Radio (Sirius 112/XM 157)brings you this insightful look at how a colorful Mexican game of chance inspired him to succeed in life. "The Chalupa Rules" combines his family's timeless proverbs,traditional Spanish sayings, and powerful imagery to create a blueprint for success. Mario grew up facing tremendous challenges that included poverty and living in a government-sponsored home. With his handcrafted rules-of-life Mario went on to become the first full-time, Mexican-American news anchor in New York City's English television. An award-winning playwright and Emmy-Nominated news anchor/reporter, Mario shares his insights into how your own cultural background can provide the inspiration to reach the American Dream. Part autobiography, part instructional manual, The Chalupa Rules offers readers of diverse cultural backgrounds a universal message of success and fulfillment in the career of your choice. Mario Bosquez, nominated for a James Beard Award for Excellent in Broadcasting, lived the Chalupa Rules and shows us all how we can do the same.

Winner of the 2010 Distinguished Book Award in Latino Studies from the Latin American Studies Association Illegal immigrant, tax burden, job stealer. Patriot, family oriented, hard worker, model consumer. Ever since Latinos became the largest minority in the U.S. they have been caught between these wildly contrasting characterizations leaving us to wonder: Are Latinos friend or foe? Latino Spin cuts through the spin about Latinos' supposed values, political attitudes, and impact on U.S. national identity to ask what these caricatures suggest about Latinos' shifting place in the popular and political imaginary. Noted scholar Arlene Dávila illustrates the growing consensus among pundits, advocates, and scholars that Latinos are not a social liability, that they are moving up and contributing, and that, in fact, they are more American than "the Americans." But what is at stake in such a sanitized and marketable representation of Latinidad? Dávila follows the spin through the realm of politics, think tanks, Latino museums, and urban planning to uncover whether they effectively challenge the growing fear over Latinos' supposedly dreadful effect on the "integrity" of U.S. national identity. What may be some of the intended or unintended consequences of these more marketable representations in regard to current debates over immigration? With particular attention to what these representations reveal about the place and role of Latinos in the contemporary politics of race, Latino Spin highlights the realities they skew and the polarization they effect between Latinos and other minorities, and among Latinos themselves along the lines of citizenship and class. Finally, by considering Latinos in all their diversity, including their increasing financial and geographic disparities, Dávila can present alternative and more empowering representations of Latinidad to help attain true political equity and intraracial coalitions.

Editing is often seen as one item on a list of steps in the writing process, usually put somewhere near the end, and often completely crowded out of writer' s workshop. Too many times daily editing lessons happen in a vacuum, with no relationship to what students are writing. In Everyday Editing , Jeff Anderson asks teachers to reflect on what sort of message this approach sends to students. Does it tell them that editing and revision are meaningful parts of the writing process, or just a hunt for errors with a 50/50 chance of getting it right,comma or no comma? Instead of rehearsing errors and drilling students on what' s wrong with a sentence, Jeff invites students to look carefully at their writing along with mentor texts, and to think about how punctuation, grammar, and style can be best used to hone and communicate meaning. Written in Jeff' s characteristically witty style, this refreshing and practical guide offers an overview of his approach to editing within the writing workshop as well as ten detailed sets of lessons covering everything from apostrophes to serial commas. These lessons can be used throughout the year to replace Daily Oral Language or error-based editing strategies with a more effective method for improving student writing.

A comprehensive review of contemporary research in the vision sciences, reflecting the rapid advances of recent years. Visual science is the model system for neuroscience, its findings relevant to all other areas. This essential reference to contemporary visual neuroscience covers the extraordinary range of the field today, from molecules and cell assemblies to systems and therapies. It provides a state-of-the art companion to the earlier book The Visual Neurosciences (MIT Press, 2003). This volume covers the dramatic advances made in the last decade, offering new topics, new authors, and new chapters. The New Visual Neurosciences assembles groundbreaking research, written by international authorities. Many of the 112 chapters treat seminal topics not included in the earlier book. These new topics include retinal feature detection; cortical connectomics; new approaches to mid-level vision and spatiotemporal perception; the latest understanding of how multimodal integration contributes to visual perception; new theoretical work on the role of neural oscillations in information processing; and new molecular and genetic techniques for understanding visual system development. An entirely new section covers invertebrate vision, reflecting the importance of this research in understanding fundamental principles of visual processing. Another new section treats translational visual neuroscience, covering recent progress in novel treatment modalities for optic nerve disorders, macular degeneration, and retinal cell replacement. The New Visual Neurosciences is an indispensable reference for students, teachers, researchers, clinicians, and anyone interested in contemporary neuroscience. Associate Editors Marie Burns, Joy Geng, Mark Goldman, James Handa, Andrew Ishida, George R. Mangun, Kimberley McAllister, Bruno Olshausen, Gregg Recanzone, Mandyam Srinivasan, W.Martin Usrey, Michael Webster, David Whitney Sections Retinal Mechanisms and Processes Organization of Visual Pathways Subcortical Processing Processing in Primary Visual Cortex Brightness and Color Pattern, Surface, and Shape Objects and Scenes Time, Motion, and Depth Eye Movements Cortical Mechanisms of Attention, Cognition, and Multimodal Integration Invertebrate Vision Theoretical Perspectives Molecular and Developmental Processes Translational Visual Neuroscience

Antimicrobial resistance (AMR) is a biological mechanism whereby a microorganism evolves over time to develop the ability to become resistant to antimicrobial therapies such as antibiotics. The drivers of and potential solutions to AMR are complex, often spanning multiple sectors. The internationally recognized response to AMR advocates for a ‘One Health’ approach, which requires policies to be developed and implemented across human, animal, and environmental health.

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The book In the Shadow of Munich. British Policy towards Czechoslovakia from the Endorsement to the Renunciation of the Munich Agreement (1938 to 1942) analyses the varying attitudes and gradual change of British policy towards Czechoslovakia in the period from the Munich Conference in September 1938 to August 1942 when the British government proclaimed the Munich Agreement as dead and thus having no influence whatsoever on the future territorial settlement. The key focus of this work lies in the influence of 'Munich' upon the British political scene and upon the resulting British policy towards Czechoslovakia in the Central European context and also in the repercussions of Munich in negotiations with the Czechoslovak exile representatives. The book is a result of many years of the author?s research conducted primarily in the British and the Czech archives as well as his reflection of numerous documentary editions, diaries, memoirs and secondary sources. It aims to dispel frequent myths and stereotypes that have so far influenced the Czech and partly also Anglo-Saxon historiography in their interpretations of British attitudes towards Czechoslovakia immediately before and during the Second World War.

Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters