Assembling a program in bioinorganic chemistry that is scientifi cally relevant, well defined, and self-consistent is not an easy task. In this attempt we decided to consider zinc enzymes, copper oxidases, cytochromes and cytochrome oxidase. The choice is in part due to the great attention that the current specialized literature devotes to these topics, which are now debated among chemists, biochemists, biophysicists, etc .. We believe that hydration reactions, hydrolytic and oxidative processes have much in common from the point of view of the reaction mechanisms, the comprehension of which represents a frontier of science. For these reasons these topics have been the subject of the NATO-ASI held at San Miniato, Pisa, Italy, from May 28 to June 8, 1982. We hope we can transfer here the main conclusions of what (we believe) was a very stimulating scientific meeting. We would like to thank the local saving bank, Cassa di Risparmio di San Miniato, for helping in many ways. The financial contribution from the European Research Office of the US Army, and from the Bruker Spectrospin s.r.l., Italy, is also acknowledged. The National Science Foundation of the United States has provided a travel grant to one of the participants from the U.S.A. We are grateful to the NATO Scientific Affairs Division which provided a grant to finance this Institute.

Industrial applications of Metal complexes have gained significant importance especially in the area of Catalysis in the last three decades. Scope for further development of such applications is extensive as several biological processes in living cells involve metal complexes. Coordination Chemistry is a subject uniquely involving application of Quantum Mechanics, Spectroscopy, Kinetics, Catalysis, Biology and Industrial Chemistry. This book has been written keeping these important aspects of the subject in mind.

At the heart of coordination chemistry lies the coordinate bond, in its simplest sense arising from donation of a pair of electrons from a donor atom to an empty orbital on a central metalloid or metal. Metals overwhelmingly exist as their cations, but these are rarely met ‘naked’ – they are clothed in an array of other atoms, molecules or ions that involve coordinate covalent bonds (hence the name coordination compounds). These metal ion complexes are ubiquitous in nature, and are central to an array of natural and synthetic reactions. Written in a highly readable, descriptive and accessible style Introduction to Coordination Chemistry describes properties of coordination compounds such as colour, magnetism and reactivity as well as the logic in their assembly and nomenclature. It is illustrated with many examples of the importance of coordination chemistry in real life, and includes extensive references and a bibliography. Introduction to Coordination Chemistry is a comprehensive and insightful discussion of one of the primary fields of study in Inorganic Chemistry for both undergraduate and non-specialist readers.

This series provides inorganic chemists and materials scientists with a forum for critical, authoritative evaluations of advances in every area of the discipline. Volume 57 continues to report recent advances with a significant, up-to-date selection of contributions from internationally-recognized researchers. The chapters of this volume are devoted to the following topics: Mechanisms of Water Oxidation Catalyzed by Ruthenium Coordination Complexes; Biomimetic and non-biological dinuclear Mx+-complex catalyzed alcoholysis reactions of phosphoryl transfer reactions; Photoactivated DNA Cleavage and Anticancer Activity of 3d-Metal Complexes; and more.

This is a textbook for advanced undergraduate inorganic chemistry courses, covering elementary inorganic reaction chemistry through to more advanced inorganic theories and topics. The approach integrates bioinorganic, environmental, geological and medicinal material into each chapter, and there is a refreshing empirical approach to problems in which the text emphasizes observations before moving onto theoretical models. There are worked examples and solutions in each chapter combined with chapter-ending study objectives, 40-70 exercises per chapter and experiments for discovery-based learning.

A collection of articles on various topics of organic synthesis -- short, precise and topical, written by leading experts in their fields. Organic synthesis is a core subject in organic chemistry, and volumes I and II have been very successful. The topics reflect modern and up-to-date problems and research areas in organic synthesis. Readers will learn about the key synthetic strategies that are important in their daily work. A large number of references is included for each article, making the primary literature easily accessible. This is a 'must-have' book for any organic chemist, organometallic chemist, natural product chemist or graduate student.

Coordination Chemistry–XIV provides information pertinent to the fundamental characteristics and synthesis of coordination compounds. This book discusses the importance of undertaking accurate X-ray analysis of a wide-ranging series of complexes in order to derive more secure theoretical correlations. Organized into 13 chapters, this book begins with an overview of the properties of alkyl and aryl derivatives of transition elements. This text then describes the two methods that lead to transition metal complexes of carborane ligands, namely, polyhedral expansion and polyhedral contraction. Other chapters consider the argument that organo-transition metal complexes also consisting phosphines and similar ligands are often too kinetically inert to act as good models for catalytic processes. This book discusses as well the developments in the mechanisms of substitution in transition metal complexes. The final chapter deals with the calibration of low resolution spectrometers. This book is a valuable resource for chemists, organometallic chemists, and inorganic chemists.

Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Chemistry, to form a trio of works covering the whole of modern inorganic chemistry. Chapters are designed to provide a valuable, long-standing scientific resource for both advanced students new to an area and researchers who need further background or answers to a particular problem on the elements, their compounds, or applications. Chapters are written by teams of leading experts, under the guidance of the Volume Editors and the Editors-in-Chief. The articles are written at a level that allows undergraduate students to understand the material, while providing active researchers with a ready reference resource for information in the field. The chapters will not provide basic data on the elements, which is available from many sources (and the original work), but instead concentrate on applications of the elements and their compounds. Provides a comprehensive review which serves to put many advances in perspective and allows the reader to make connections to related fields, such as: biological inorganic chemistry, materials chemistry, solid state chemistry and nanoscience Inorganic chemistry is rapidly developing, which brings about the need for a reference resource such as this that summarise recent developments and simultaneously provide background information Forms the new definitive source for researchers interested in elements and their applications; completely replacing the highly cited first edition, which published in 1973

Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-resistance. Chapters include Transcriptomic Analysis Reveals Zinc-Mediated Virulence and Pathogenicity in Multidrug-Resistant Acinetobacter baumannii, The Mechanistic Insights into Different Aspects of Promiscuity in Metalloenzymes, Role of Metal ion in ion channel Mechanisms, A model of microtubule depolymerization by kinesin-8 motor proteins, Metalloproteins and metalloproteomics in health and disease, Decoding Genetic and Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis: A Comparative Study of Differentially Expressed Genes and Implicated Pathways in Motor Neuron Disorders, and much more. Additional chapters cover Exploring the effect of disease causing mutations in metal binding sites of human ARSA in Metachromatic Leukodystrophy, Role of transmembrane proteins in regulating metalloproteins and motor proteins in human cancer, Role of transmembrane proteins in metalloproteins and motor proteinsin human neurogenesis, Role of transmembrane proteins in metalloproteins and motor proteins in human aging, Vesicle transport of metalloproteinases, Motor proteins and spermatogenesis, and much more. Integrates experimental and computational methods for studying structure and function of metalloproteins and motor proteins and their implication in drug design Presents timely chapters written by well-renowned authorities in their field Contains a high number of high quality illustrations, figures, and tables and targets a very wide audience of specialists, researchers, and students

The present book might be regarded as a sequel to my previous work, Bioinorganic Chemistry: An Introduction (Allyn and Bacon, 1977). The latter is essentially a collection of chemical and physical data pertinent to an understanding of the biological functions of the various elements and the proteins dependent on them. The ten years since its publication have seen an enormous increase in research activity in this area, hence of research papers. A number of monographs and review series on specific topics have also appeared, including the volumes in the series of which the present volume is a part. Nevertheless, a gap has developed between the flood of information available at a detailed level (papers and reviews) and a general description of the underlying principles of biofunctions of the elements as presently conceived. It is hoped that this book will help bridge this gap and at the same time provide an overview of the entire Biochemistry of the Elements series. Specifically, the work attempts to focus on "why" questions, especially, "Why has an element been chosen by organisms for a specific biofunction?" and "Why does an element behave the way it does in biological systems?" It therefore complements my 1977 book and, together with Laboratory Introduction to Bio-Inorganic Chemistry (E. -I. Ochiai and D. R. Williams, Macmillan, 1979), completes a trilogy on the topic of bioinorganic chemistry. This book consists of five parts. Two chapters constitute Part I.